Motor sequence learning in a goal‐directed stepping task in persons with multiple sclerosis: a pilot study

2021 ◽  
Author(s):  
Renee Veldkamp ◽  
Lousin Moumdjian ◽  
Kim Dun ◽  
Joren Six ◽  
Antoine Vanbeylen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Sequence Learning ◽  
Motor Sequence Learning ◽  
Motor Sequence

scholarly journals Motor Sequence Learning across Multiple Sessions Is Not Facilitated by Targeting Consolidation with Posttraining tDCS in Patients with Progressive Multiple Sclerosis

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Harald Seelmann-Eggebert ◽  
Muriel Stoppe ◽  
Florian Then Bergh ◽  
Joseph Classen ◽  
Jost-Julian Rumpf
Keyword(s):  
Multiple Sclerosis ◽  
Motor Learning ◽  
Task Performance ◽  
Sequence Learning ◽  
Primary Motor Cortex ◽  
Training Session ◽  
Motor Sequence Learning ◽  
Motor Sequence ◽  
Double Blind ◽  
Cross Sectional

Compared to relapsing-remitting multiple sclerosis (MS), progressive MS is characterized by a lack of spontaneous recovery and a poor response to pharmaceutical immunomodulatory treatment. These patients may, therefore, particularly benefit from interventions that augment training-induced plasticity of the central nervous system. In this cross-sectional double-blind cross-over pilot study, effects of transcranial direct current stimulation (tDCS) on motor sequence learning were examined across four sessions on days 1, 3, 5, and 8 in 16 patients with progressive MS. Active or sham anodal tDCS of the primary motor cortex was applied immediately after each training session. Participants took part in two experiments separated by at least four weeks, which differed with respect to the type of posttraining tDCS (active or sham). While task performance across blocks of training and across sessions improved significantly in both the active and sham tDCS experiment, neither online nor offline motor learning was modulated by the type of tDCS. Accordingly, the primary endpoint (task performance on day 8) did not differ between stimulation conditions. In sum, patients with progressive MS are able to improve performance in an ecologically valid motor sequence learning task through training. However, even multisession posttraining tDCS fails to promote motor learning in progressive MS.

Selective impairments of motor sequence learning in multiple sclerosis patients with minimal disability

2014 ◽  
Vol 1585 ◽  
pp. 91-98 ◽  
Author(s):  
Andrea Tacchino ◽  
Marco Bove ◽  
Luca Roccatagliata ◽  
Giovanni Luigi Mancardi ◽  
Antonio Uccelli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sequence Learning ◽  
Motor Sequence Learning ◽  
Motor Sequence ◽  
Multiple Sclerosis Patients

The Time Course of Changes during Motor Sequence Learning: A Whole-Brain fMRI Study

NeuroImage ◽  
1998 ◽  
Vol 8 (1) ◽  
pp. 50-61 ◽  
Author(s):  
Ivan Toni ◽  
Michael Krams ◽  
Robert Turner ◽  
Richard E. Passingham
Keyword(s):  
Sequence Learning ◽  
Time Course ◽  
Motor Sequence Learning ◽  
Motor Sequence ◽  
Whole Brain ◽  
Fmri Study ◽  
Brain Fmri

scholarly journals Does sleep facilitate the consolidation of allocentric or egocentric representations of implicitly learned visual-motor sequence learning?

2018 ◽  
Vol 25 (2) ◽  
pp. 67-77 ◽  
Author(s):  
Jeremy Viczko ◽  
Valya Sergeeva ◽  
Laura B. Ray ◽  
Adrian M. Owen ◽  
Stuart M. Fogel
Keyword(s):  
Sequence Learning ◽  
Motor Sequence Learning ◽  
Motor Sequence ◽  
Visual Motor
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