Toward the massive genome of Proteus anguinus —illuminating longevity, regeneration, convergent evolution, and metabolic disorders

SummaryWe have demonstrated previously that fibrin enhanced plasmin formation by the vascular plasminogen activator was significantly impaired, when components isolated from the plasma of three uncontrolled diabetic patients (type I) were used to study plasminogen activation in vitro. In the present study it can be demonstrated that functional properties of the vascular plasminogen activators as well as of the plasminogens from the same three diabetic patients are significantly improved after normalization of blood sugar levels and improvement of HbAlc values. Most pronounced the Km of diabetic vascular plasminogen activator in the presence of fibrin returned to normal values, and for diabetic plasminogen the prolonged lag period until maximal plasmin formation occurred was shortened to almost control values. From these data we conclude that the observed abnormalities of in vitro fibrinolysis are not primarily associated with the diabetic disease, but might be secondary to metabolic disorders caused by diabetes.

Download Full-text

Morbidity of children with diseases of the endocrine system, eating disorders and metabolic disorders in the Khabarovsk Krai: current situation and trends

Public health of the Far East Peer-reviewed scientific and practical journal ◽

10.33454/1728-1261-2020-1-4-10 ◽

2020 ◽

Vol 1 ◽

pp. 4-10

Author(s):

L.K Prisyazhnyk ◽

◽

K.P. Topalov ◽

Keyword(s):

Eating Disorders ◽

Metabolic Disorders ◽

Endocrine System ◽

Current Situation ◽

Khabarovsk Krai

Download Full-text

Clinical, morphological and biochemical signs of polymycotoxicosis in highly productive cows

Veterinaria Kubani ◽

10.33861/2071-8020-2020-4-14-17 ◽

2020 ◽

pp. 14-17

Author(s):

Irina A. Shkuratova ◽

◽

Lyudmila I. Drozdova ◽

Aleksander I. Belousov ◽

Keyword(s):

Metabolic Disorders ◽

Hepatorenal Syndrome ◽

Morphological Changes ◽

Clinical Manifestations ◽

The Body ◽

Feed Mixture ◽

Milk Productivity ◽

Structural Disorders ◽

Increased Sensitivity ◽

Penicillium Spp

Mycotoxicological monitoring of forages shows that the problem of mycotoxicosis has been relevant for several decades. Minimal doses of mycotoxins in feed lead to a decrease in milk productivity, increased sensitivity to infectious and non-infectious diseases. When several mycotoxins enter the body simultaneously, a synergistic effect develops, causing a significant increase in toxicity. Feed contaminated with several types of fungi and their toxins is dangerous for dairy cattle. It was found that the feed mixture contained the types of associations of Aspergillus spp. fungi + Fusarium; Aspergillus spp. + Penicillium spp. + Mucor spp; Fusarium + Penicillium; Mucor spp. + Fusarium + Ustilaginales. Pathogenetic features of metabolic and morphological changes in highly productive cows with polymycotoxicosis were studied. Feeding food contaminated with various metabolites of mold fungi leads to the development of signs of chronic toxemia in animals. Clinical manifestations are the development of diarrhea and dehydration, with a decrease in milk productivity. Metabolic disorders feature the development of an inflammatory process, metabolic acidosis, hyperfermentonemia, with an increase in the amount of creatinine and urea in the blood serum. Metabolic signs indicate the development of hepatorenal syndrome due to structural disorders of the liver and kidneys. Histological signs of polymicotoxicosis are intracapillary and hemorrhagic glomerulonephritis, hepatocyte micronecrosis, and proliferation of connective tissue stroma cells, which leads to the development of atrophic cirrhosis in the interstitial and circular phases.

Download Full-text