scholarly journals Runx2 and microRNA regulation in bone and cartilage diseases

2016 ◽  
Vol 1383 (1) ◽  
pp. 80-87 ◽  
Author(s):  
Weiwei Zhao ◽  
Shanxing Zhang ◽  
Baoli Wang ◽  
Jian Huang ◽  
William W. Lu ◽  
...  
Keyword(s):  
Microrna Regulation ◽  
Cartilage Diseases ◽  
And Cartilage

scholarly journals Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

2019 ◽  
Vol 16 (8) ◽  
pp. 795-813 ◽  
Author(s):  
Ana Cláudia Lima ◽  
Helena Ferreira ◽  
Rui L. Reis ◽  
Nuno M. Neves
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymers ◽  
Cartilage Diseases ◽  
And Cartilage

scholarly journals Recent Progress in 3D Printing of Elastic and High-Strength Hydrogels for the Treatment of Osteochondral and Cartilage Diseases

2020 ◽  
Vol 8 ◽  
Author(s):  
Wenli Dai ◽  
Muyang Sun ◽  
Xi Leng ◽  
Xiaoqing Hu ◽  
Yingfang Ao
Keyword(s):  
Articular Cartilage ◽  
3D Printing ◽  
Recent Progress ◽  
High Strength ◽  
Cartilage Defects ◽  
High Water Content ◽  
Covalent Bonds ◽  
Cartilage Diseases ◽  
Articular Cartilage Defects ◽  
And Cartilage

Despite considerable progress for the regenerative medicine, repair of full-thickness articular cartilage defects and osteochondral interface remains challenging. This low efficiency is largely due to the difficulties in recapitulating the stratified zonal architecture of articular cartilage and engineering complex gradients for bone-soft tissue interface. This has led to increased interest in three-dimensional (3D) printing technologies in the field of musculoskeletal tissue engineering. Printable and biocompatible hydrogels are attractive materials for 3D printing applications because they not only own high tunability and complexity, but also offer favorable biomimetic environments for live cells, such as porous structure, high water content, and bioactive molecule incorporation. However, conventional hydrogels are usually mechanically weak and brittle, which cannot reach the mechanical requirements for repair of articular cartilage defects and osteochondral interface. Therefore, the development of elastic and high-strength hydrogels for 3D printing in the repairment of cartilage defects and osteochondral interface is crucial. In this review, we summarized the recent progress in elastic and high-strength hydrogels for 3D printing and categorized them into six groups, namely ion bonds interactions, nanocomposites integrated in hydrogels, supramolecular guest–host interactions, hydrogen bonds interactions, dynamic covalent bonds interactions, and hydrophobic interactions. These 3D printed elastic and high-strength hydrogels may provide new insights for the treatment of osteochondral and cartilage diseases.

Markers of Bone and Cartilage Turnover

2017 ◽  
Vol 125 (07) ◽  
pp. 454-469 ◽  
Author(s):  
Henning Woitge ◽  
Markus Seibel
Keyword(s):  
Bone Mineral ◽  
Clinical Value ◽  
Tissue Specific ◽  
Musculoskeletal Tissue ◽  
Cartilage Metabolism ◽  
The Past ◽  
Cartilage Diseases ◽  
And Cartilage ◽  
Cartilage Turnover

AbstractOver the past few decades, scientists have been trying to identify tissue-specific markers that would help to better understand the pathogenesis of bone and cartilage diseases and could be used clinically for the screening, diagnosis and follow-up of bone or joint diseases. Historically, only a few components known to be involved in bone, mineral or cartilage turnover were available for this purpose (e. g., urine hydroxyproline, serum and urine calcium and phosphate levels). However, since most if not all of these substances have wider biological functions beyond bone, mineral and cartilage metabolism, their clinical value as tissue-specific markers was limited. Hence, there was a need to identify more specific indices of bone and cartilage metabolism. Since the 1980s, a number of collagenous and non-collagenous breakdown products as well as cell-specific enzymes have been discovered and developed into markers of musculoskeletal tissue metabolism. This review describes their chemical and biological function, available analytical methods and possible clinical applications.

scholarly journals The Interaction between microRNAs and the Wnt/β-catenin Signaling Pathway in Osteoarthritis

2021 ◽  
Vol 22 (18) ◽  
pp. 9887
Author(s):  
Xiaobin Shang ◽  
Kai Oliver Böker ◽  
Shahed Taheri ◽  
Thelonius Hawellek ◽  
Wolfgang Lehmann ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Signaling Pathway ◽  
Metabolic Activity ◽  
Molecular Mechanisms ◽  
Microrna Regulation ◽  
Cellular Processes ◽  
Disease Modifying ◽  
Disease Modifying Treatment ◽  
And Cartilage

Osteoarthritis (OA) is a chronic disease affecting the whole joint, which still lacks a disease-modifying treatment. This suggests an incomplete understanding of underlying molecular mechanisms. The Wnt/β-catenin pathway is involved in different pathophysiological processes of OA. Interestingly, both excessive stimulation and suppression of this pathway can contribute to the pathogenesis of OA. microRNAs have been shown to regulate different cellular processes in different diseases, including the metabolic activity of chondrocytes and osteocytes. To bridge these findings, here we attempt to give a conclusive overview of microRNA regulation of the Wnt/β-catenin pathway in bone and cartilage, which may provide insights to advance the development of miRNA-based therapeutics for OA treatment.

scholarly journals Nanotechnology: A New Hope for the Cure of Osteoarthritis, Osteoporosis and Rheumatoid Arthritis

2020 ◽  
Vol V (I) ◽  
pp. 25-39
Author(s):  
Fariah Qaiser ◽  
Muhammad Ibrahim ◽  
Rabia Mazhar ◽  
Farhan Sohail
Keyword(s):  
Rheumatoid Arthritis ◽  
Targeted Delivery ◽  
Treatment Strategies ◽  
Promising Strategy ◽  
Advanced Technologies ◽  
Efficient Delivery ◽  
Causal Treatment ◽  
Cartilage Diseases ◽  
And Cartilage

Bone and cartilage diseases especially osteoporosis, osteoarthritis and rheumatoid arthritis are rapidly prevailing both in men and women particularly due to increase in life expectancies. Different treatments are being proposed using conventional drugs and their modifications. But the side effects associated with such drugs and difficulty in treatment strategies due to multifactorial nature of such diseases and difficulty in drug delivery led the researchers towards the development of more advanced technologies for the treatment purpose. Nanotechnology is a promising strategy for treating such diseases that suppresses the progression of such diseases providing causal treatment. In this review, we will summarize the recent nano-based targeted and non-targeted delivery systems using various types of nanoparticles, nanogels, nanocomplexes, nanocarriers, hydrogels etc. for the efficient delivery of drugs and other therapeutic agents like mRNA, genes, insulin-growth factors etc. Moreover, role of nanoparticles for bone and cartilage repair in tissue engineering will also be discussed.

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

Cleft Lip Rhinoplasty: The Role of Bone and Cartilage Grafts

1989 ◽  
Vol 16 (1) ◽  
pp. 177-186 ◽  
Author(s):  
Fernando Ortiz Monasterio ◽  
Ernesto J. Ruas
Keyword(s):  
Cleft Lip ◽  
Cartilage Grafts ◽  
And Cartilage
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