scholarly journals How to make a tumour: cell type specific dissection of Ustilago maydis- induced tumour development in maize leaves

2018 ◽  
Vol 217 (4) ◽  
pp. 1681-1695 ◽  
Author(s):  
Alexandra Matei ◽  
Corinna Ernst ◽  
Markus Günl ◽  
Björn Thiele ◽  
Janine Altmüller ◽  
...  
Keyword(s):  
Tumour Cell ◽  
Ustilago Maydis ◽  
Cell Type ◽  
Tumour Development ◽  
Maize Leaves ◽  
Cell Type Specific ◽  
Tumour Cell Type

scholarly journals Cell type specific transcriptional reprogramming of maize leaves during Ustilago maydis induced tumor formation

2019 ◽  
Author(s):  
Mitzi Villajuana-Bonequi ◽  
Alexandra Matei ◽  
Corinna Ernst ◽  
Asis Hallab ◽  
Björn Usadel ◽  
...  
Keyword(s):  
Cell Division ◽  
Genetic Model ◽  
Ustilago Maydis ◽  
Tumor Formation ◽  
Bundle Sheath ◽  
Cell Type ◽  
Transcriptional Reprogramming ◽  
Maize Leaves ◽  
Maize Cell ◽  
Cell Type Specific

SummaryUstilago maydis is a biotrophic pathogen and well-established genetic model to understand the molecular basis of biotrophic interactions. U. maydis suppresses plant defense and induces tumors on all aerial parts of its host plant maize. In a previous study we found that U. maydis induced leaf tumor formation builds on two major processes: the induction of hypertrophy in the mesophyll and the induction of cell division (hyperplasia) in the bundle sheath. In this study we analyzed the cell-type specific transcriptome of maize leaves 4 days post infection. This analysis allowed identification of key features underlying the hypertrophic and hyperplasic cell identities derived from mesophyll and bundle sheath cells, respectively. We examined the differentially expressed (DE) genes with particular focus on maize cell cycle genes and found that three A-type cyclins, one B-, D- and T-type are upregulated in the hyperplasic tumorous cells, in which the U. maydis effector protein See1 promotes cell division. Additionally, most of the proteins involved in the formation of the pre-replication complex (pre-RC, that assure that each daughter cell receives identic DNA copies), the transcription factors E2Fand DPa as well as several D-type cyclins are deregulated in the hypertrophic cells.

scholarly journals Cell type specific transcriptional reprogramming of maize leaves during Ustilago maydis induced tumor formation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mitzi Villajuana-Bonequi ◽  
Alexandra Matei ◽  
Corinna Ernst ◽  
Asis Hallab ◽  
Björn Usadel ◽  
...  
Keyword(s):  
Ustilago Maydis ◽  
Tumor Formation ◽  
Cell Type ◽  
Transcriptional Reprogramming ◽  
Maize Leaves ◽  
Cell Type Specific

IFIH1-deficiency results in a cell-type specific alteration of autophagic activity in response to S. typhimurium

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
S Macheiner ◽  
R Gerner ◽  
A Pfister ◽  
A Moschen ◽  
H Tilg
Keyword(s):  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Autophagic Activity ◽  
Specific Alteration
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