Location, location, location - no more! The unravelling of chromatin remodeling regulatory aspects of plant metabolic gene clusters

2014 ◽  
Vol 205 (2) ◽  
pp. 458-460 ◽  
Author(s):  
Alisdair R. Fernie ◽  
Takayuki Tohge
Keyword(s):  
Chromatin Remodeling ◽  
Gene Clusters ◽  
Metabolic Gene ◽  
Regulatory Aspects

scholarly journals Metabolic gene clusters encoding the enzymes of two branches of the 3-oxoadipate pathway in the pathogenic yeast Candida albicans

2015 ◽  
Vol 15 (3) ◽  
Author(s):  
Gabriela Gérecová ◽  
Martina Neboháčová ◽  
Igor Zeman ◽  
Leszek P. Pryszcz ◽  
Ľubomír Tomáška ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Gene Clusters ◽  
Pathogenic Yeast ◽  
Metabolic Gene

scholarly journals RNA sequencing of an nsdC mutant reveals global regulation of secondary metabolic gene clusters in Aspergillus flavus

2016 ◽  
Vol 182 ◽  
pp. 150-161 ◽  
Author(s):  
Matthew K. Gilbert ◽  
Brian M. Mack ◽  
Qijian Wei ◽  
John M. Bland ◽  
Deepak Bhatnagar ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Aspergillus Flavus ◽  
Gene Clusters ◽  
Global Regulation ◽  
Metabolic Gene

scholarly journals Delineation of metabolic gene clusters in plant genomes by chromatin signatures

2016 ◽  
Vol 44 (5) ◽  
pp. 2255-2265 ◽  
Author(s):  
Nan Yu ◽  
Hans-Wilhelm Nützmann ◽  
James T. MacDonald ◽  
Ben Moore ◽  
Ben Field ◽  
...  
Keyword(s):  
Gene Clusters ◽  
Plant Genomes ◽  
Metabolic Gene

scholarly journals Genome Sequence of Streptomyces caatingaensis CMAA 1322, a New Abiotic Stress-Tolerant Actinomycete Isolated from Dried Lake Bed Sediment in the Brazilian Caatinga Biome

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Suikinai Nobre Santos ◽  
Ranko Gacesa ◽  
Rodrigo Gouvêa Taketani ◽  
Paul F. Long ◽  
Itamar Soares Melo
Keyword(s):  
Abiotic Stress ◽  
Environmental Stress ◽  
Stress Tolerance ◽  
Genome Sequence ◽  
Gene Clusters ◽  
Bed Sediment ◽  
Metabolic Gene ◽  
Caatinga Biome

The genome sequence of the first Streptomyces species isolated from the Brazilian Caatinga is reported here. Genes related to environmental stress tolerance were prevalent and included many secondary metabolic gene clusters.

scholarly journals The PhytoClust tool for metabolic gene clusters discovery in plant genomes

2017 ◽  
Vol 45 (12) ◽  
pp. 7049-7063 ◽  
Author(s):  
Nadine Töpfer ◽  
Lisa-Maria Fuchs ◽  
Asaph Aharoni
Keyword(s):  
Gene Clusters ◽  
Plant Genomes ◽  
Metabolic Gene

scholarly journals Modularity of Plant Metabolic Gene Clusters: A Trio of Linked Genes That Are Collectively Required for Acylation of Triterpenes in Oat

2013 ◽  
Vol 25 (3) ◽  
pp. 1078-1092 ◽  
Author(s):  
Sam T. Mugford ◽  
Thomas Louveau ◽  
Rachel Melton ◽  
Xiaoquan Qi ◽  
Saleha Bakht ◽  
...  
Keyword(s):  
Gene Clusters ◽  
Metabolic Gene

scholarly journals H3K9 Methylation Regulates Growth and Development in Aspergillus fumigatus

2008 ◽  
Vol 7 (12) ◽  
pp. 2052-2060 ◽  
Author(s):  
Jonathan M. Palmer ◽  
Robyn M. Perrin ◽  
Taylor R. T. Dagenais ◽  
Nancy P. Keller
Keyword(s):  
Aspergillus Fumigatus ◽  
Chromatin Remodeling ◽  
Gene Clusters ◽  
Developmental Competence ◽  
Developmental Defects ◽  
Heterochromatin Formation ◽  
Host Interactions ◽  
Disease States ◽  
Eukaryotic Species ◽  
Growth Abnormalities

ABSTRACT In most species, chromatin remodeling mediates critical biological processes ranging from development to disease states. In fungi within the genus Aspergillus, chromatin remodeling may regulate expression of metabolic gene clusters, but other processes regulated by chromatin structure remain to be elucidated. In many eukaryotic species, methylation of lysine 9 of histone 3 (H3K9) is a hallmark of heterochromatin formation and subsequent gene silencing. The sole H3K9 methyltransferase in Schizosaccharomyces pombe is Clr4. We report that disruption of the Clr4 homolog in the pathogenic mold Aspergillus fumigatus (ClrD), which is involved in both mono- and trimethylation of H3K9, results in several growth abnormalities. Developmental defects in ΔAfclrD include reduction in radial growth, reduction in conidial production, and delayed conidiation after developmental competence mediated by delayed expression of brlA, the master regulator of conidiophore development. Sensitivity of ΔAfclrD to 6-azauracil suggests that ClrD influences transcriptional processing in A. fumigatus. Despite growth abnormalities, macrophage assays suggest ClrD may be dispensable for host interactions.

Bioinformatics Approaches and Software for Detection of Secondary Metabolic Gene Clusters

2012 ◽  
pp. 23-45 ◽  
Author(s):  
Natalie D. Fedorova ◽  
Venkatesh Moktali ◽  
Marnix H. Medema
Keyword(s):  
Gene Clusters ◽  
Metabolic Gene
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