Discriminant ability of the 3‐ounce water swallow test to detect aspiration in amyotrophic lateral sclerosis

2021 ◽  
Author(s):  
Cara Donohue ◽  
Lauren Tabor Gray ◽  
Jennifer Chapin ◽  
Amber Anderson ◽  
Lauren DiBiase ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Discriminant Ability ◽  
Lateral Sclerosis

scholarly journals Discriminant ability of the Eating Assessment Tool-10 to detect aspiration in individuals with amyotrophic lateral sclerosis

2015 ◽  
Vol 28 (1) ◽  
pp. 85-90 ◽  
Author(s):  
E. K. Plowman ◽  
L. C. Tabor ◽  
R. Robison ◽  
J. Gaziano ◽  
C. Dion ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Assessment Tool ◽  
Discriminant Ability ◽  
Lateral Sclerosis

scholarly journals Functional and Endoscopic Indicators for Percutaneous Endoscopic Gastrostomy (PEG) in Amyotrophic Lateral Sclerosis Patients

2018 ◽  
Vol 7 (10) ◽  
pp. 352 ◽  
Author(s):  
Bebiana Conde ◽  
Natália Martins ◽  
Inês Rodrigues ◽  
Ana Pimenta ◽  
João Winck
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Rating Scale ◽  
Ventilatory Support ◽  
Functional Evaluation ◽  
Oral Nutrition ◽  
Additional Information ◽  
Endoscopic Gastrostomy ◽  
Discriminant Ability ◽  
Als Patients ◽  
Lateral Sclerosis

(1) Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition, whose bulbar involvement compromises language, swallowing, and airway protection. When oral nutrition is no longer adequate, percutaneous endoscopic gastroscopy (PEG) may be indicated. However, as exact timing is still debatable, we tried to find it. (2) Methods: A prospective cohort study was performed using fiber-optic endoscopic evaluation of swallowing (FEES), functional evaluation scales (ALS Functional Rating Scale-Revised (ALSFRS-R) and bulbar sub-score (ALSFRS-R-B)), lung function tests (like Forced Vital Capacity (FVC), Cough Peak Flow (CPF)) and anthropometric data. (3) Results: Twenty-three patients were enrolled (mean 65.4 ± 9.1 years, 60.9% males), 12 with spinal-onset. During the study period, 58 FEES were performed (1–4/patients). Even before formal the PEG indication, suggestions were given to correct the alterations found. PEG was placed in 12 patients, on average 21.8 months after diagnosis (FVC = 69.9% ± 26.7%, ALSFRS-R-B = 7.7 ± 3.7, ALSFRS-R = 28.9 ± 12.3), and being 91.7% under ventilatory support. ALSFRS-R-B, CPF, FVC, and ALSFRS-R showed significant discriminant ability for PEG placement. Sensitivity and specificity were, respectively, ALSFRS-R-B ≤ 8 (100/90.9), CPF ≤ 205 (83.3), FVC ≤ 74 (83.3/74.2), and ALSFRS-R < 29 (83.3/65.1). (4) Conclusions: FEES provide additional information beyond formal PEG indication. ALSFRS-R-B score ≤ 8 was found as a best functional and noninvasive indicator for PEG performance in ALS patients.

Automated Acoustic Analysis of Oral Diadochokinesis to Assess Bulbar Motor Involvement in Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 63 (1) ◽  
pp. 59-73 ◽  
Author(s):  
Panying Rong
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Acoustic Analysis ◽  
Speaking Rate ◽  
Disease Stage ◽  
Healthy Controls ◽  
Tongue Movement ◽  
Major Barrier ◽  
Syllable Repetition ◽  
Oral Diadochokinesis ◽  
Lateral Sclerosis

Purpose The purpose of this article was to validate a novel acoustic analysis of oral diadochokinesis (DDK) in assessing bulbar motor involvement in amyotrophic lateral sclerosis (ALS). Method An automated acoustic DDK analysis was developed, which filtered out the voice features and extracted the envelope of the acoustic waveform reflecting the temporal pattern of syllable repetitions during an oral DDK task (i.e., repetitions of /tɑ/ at the maximum rate on 1 breath). Cycle-to-cycle temporal variability (cTV) of envelope fluctuations and syllable repetition rate (sylRate) were derived from the envelope and validated against 2 kinematic measures, which are tongue movement jitter (movJitter) and alternating tongue movement rate (AMR) during the DDK task, in 16 individuals with bulbar ALS and 18 healthy controls. After the validation, cTV, sylRate, movJitter, and AMR, along with an established clinical speech measure, that is, speaking rate (SR), were compared in their ability to (a) differentiate individuals with ALS from healthy controls and (b) detect early-stage bulbar declines in ALS. Results cTV and sylRate were significantly correlated with movJitter and AMR, respectively, across individuals with ALS and healthy controls, confirming the validity of the acoustic DDK analysis in extracting the temporal DDK pattern. Among all the acoustic and kinematic DDK measures, cTV showed the highest diagnostic accuracy (i.e., 0.87) with 80% sensitivity and 94% specificity in differentiating individuals with ALS from healthy controls, which outperformed the SR measure. Moreover, cTV showed a large increase during the early disease stage, which preceded the decline of SR. Conclusions This study provided preliminary validation of a novel automated acoustic DDK analysis in extracting a useful measure, namely, cTV, for early detection of bulbar ALS. This analysis overcame a major barrier in the existing acoustic DDK analysis, which is continuous voicing between syllables that interferes with syllable structures. This approach has potential clinical applications as a novel bulbar assessment.

Amyotrophic Lateral Sclerosis Assessment Questionnaire-5--Turkish Version

2019 ◽  
Author(s):  
Naile Alankaya ◽  
Zeliha Tülek ◽  
Aylin Özakgül ◽  
Alper Kaya ◽  
Aynur Dik
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Turkish Version ◽  
Assessment Questionnaire ◽  
Lateral Sclerosis

Amyotrophic Lateral Sclerosis Assessment Questionnaire-40--Turkish Version

2019 ◽  
Author(s):  
Naile Alankaya ◽  
Zeliha Tülek ◽  
Aylin Özakgül ◽  
Alper Kaya ◽  
Aynur Dik
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Turkish Version ◽  
Assessment Questionnaire ◽  
Lateral Sclerosis
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