The herbal preparation STW 5 affects serotonergic pathways in the brain and colon as well as stress parameters in experimental irritable bowel syndrome

2021 ◽  
Author(s):  
Nehal G. gamal ◽  
Rania M. Abd El‐Salam ◽  
Laila N. Gadelrub ◽  
Omar A. Ahmed‐Farid ◽  
Mohamed T. Khayyal
Keyword(s):  
Irritable Bowel Syndrome ◽  
Herbal Preparation ◽  
Irritable Bowel ◽  
As Stress ◽  
The Brain ◽  
Stress Parameters

scholarly journals PSYCHOLOGICAL FEATURES OF CHILDREN WITH IRRITABLE BOWEL SYNDROME

2020 ◽  
Vol 20 (1) ◽  
pp. 91-95
Author(s):  
A.V. Zubarenko ◽  
V.V. Luzan ◽  
T.Yu. Kravchenko ◽  
G.K. Kopiyka ◽  
V.I. Martyuk
Keyword(s):  
Irritable Bowel Syndrome ◽  
Emotional Disorders ◽  
Functional Gastrointestinal Disorders ◽  
Psychological Disorders ◽  
Gastrointestinal Disorders ◽  
Depressed Type ◽  
Clinical Variant ◽  
Irritable Bowel ◽  
Psychological Features ◽  
The Brain

Functional gastrointestinal disorders are considered as a clinical variant of the interaction between psychosocial factors and gastrointestinal tract physiology implemented through the "brain - intestine" axis. The purpose of the study was to investigate psychological peculiarities of children with irritable bowel syndrome. The study included 68 children aged from 14 to 18 years with the confirmed diagnosis of irritable bowel syndrome. To determine the type of character accentuation, the Schmishek -Leonhard test questionnaire (child version) was used. The SCL-90-R test questionnaire (by L. Derogatis method) was applied to determine psycho-emotional disorders. The study has found out the majority of patients have certain psycho-emotional disorders. The group of children with irritable bowel syndrome, who were experiencing constipation, more frequently demonstrated an emotional type of character accentuation and a somatized and depressed type of psychological disorders. The patients with irritable bowel syndrome and diarrhoea had cycloid and demonstrative types of character accentuation and demonstrated an anxious type according to the questionnaire. The patients with mixed bowel rhythms exhibited features of a cycloid, emotional, and pedantic type of character accentuation. Depression, anxiety, somatised types were reported as manifestations of psychological disorders.

scholarly journals Is It the Brain-Gut or the Gut-Brain That Drives Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD)?

2011 ◽  
Vol 140 (5) ◽  
pp. S-462 ◽  
Author(s):  
Natasha A. Koloski ◽  
Michael Jones ◽  
Jamshid S. Kalantar ◽  
Martin D. Weltman ◽  
Jessa Zaguirre ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Dyspepsia ◽  
Irritable Bowel ◽  
The Brain

scholarly journals Sleep and gastric function in irritable bowel syndrome: derailing the brain-gut axis

Gut ◽  
1997 ◽  
Vol 41 (3) ◽  
pp. 390-393 ◽  
Author(s):  
W C Orr ◽  
M D Crowell ◽  
B Lin ◽  
M J Harnish ◽  
J D Z Chen
Keyword(s):  
Irritable Bowel Syndrome ◽  
Rem Sleep ◽  
Bowel Function ◽  
Control Group ◽  
Gastric Function ◽  
Subsequent Increase ◽  
Surface Electrodes ◽  
Non Invasive ◽  
Irritable Bowel ◽  
The Brain

Background—Recently, several studies have shown an alteration in bowel function during sleep in patients with irritable bowel syndrome (IBS), and a recent study also suggests a remarkable increase in rapid eye movement (REM) sleep. These studies have suggested that an alteration in CNS function may play an important role in the pathogenesis of IBS.Aims—To confirm the presence of an alteration in REM sleep in patients with IBS and to assess the relation between sleep and a non-invasive measure of gastric functioning, the electrogastrogram (EGG).Patients—Ten patients with IBSand 10 age and sex matched normal volunteers.Methods—All subjects slept one night in the sleep laboratory and underwent polysomnographic monitoring to determine sleep patterns, and recording of the EGG from surface electrodes.Results—The IBS group had a notable and significant increase in the percentage and duration of REM sleep (p<0.05). The control group had a decrease in the amplitude of the dominant EGG frequency from waking to non-REM sleep (p<0.05), and a subsequent increase in the amplitude from non-REM to REM sleep (p<0.05). No such changes were noted in the patients with IBS.Conclusions—Results confirmed the enhancement of REM sleep in patients with IBS and suggested an intrinsic alteration in autonomic and CNS functioning in patients with IBS.

scholarly journals Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome

Pain ◽  
2013 ◽  
Vol 154 (9) ◽  
pp. 1528-1541 ◽  
Author(s):  
Benjamin M. Ellingson ◽  
Emeran Mayer ◽  
Robert J. Harris ◽  
Cody Ashe-McNally ◽  
Bruce D. Naliboff ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Irritable Bowel ◽  
The Brain

The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling

2014 ◽  
Vol 30 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Yingcong Yu ◽  
Shujuan Wu ◽  
Jianxin Li ◽  
Renye Wang ◽  
Xupei Xie ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Rat Model ◽  
Irritable Bowel ◽  
The Brain

scholarly journals Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome

2013 ◽  
Vol 305 (8) ◽  
pp. G529-G541 ◽  
Author(s):  
Yehuda Ringel ◽  
Nitsan Maharshak
Keyword(s):  
Irritable Bowel Syndrome ◽  
Immune Function ◽  
Intestinal Microbiota ◽  
Clinical Symptoms ◽  
Current Evidence ◽  
Future Research ◽  
Gastrointestinal Microbiota ◽  
Plausible Model ◽  
Irritable Bowel ◽  
The Brain

The pathophysiology of irritable bowel syndrome (IBS) is believed to involve alterations in the brain-gut axis; however, the etiological triggers and mechanisms by which these changes lead to symptoms of IBS remain poorly understood. Although IBS is often considered a condition without an identified “organic” etiology, emerging evidence suggests that alterations in the gastrointestinal microbiota and altered immune function may play a role in the pathogenesis of the disorder. These recent data suggest a plausible model in which changes in the intestinal microbiota and activation of the enteric immune system may impinge upon the brain-gut axis, causing the alterations in gastrointestinal function and the clinical symptoms observed in patients with IBS. This review summarizes the current evidence for altered intestinal microbiota and immune function in IBS. It discusses the potential etiological role of these factors, suggests an updated conceptual model for the pathogenesis of the disorder, and identifies areas for future research.

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