Altered gene expression signatures by calcitonin gene‐related peptide promoted mast cell activity in the colon of stress‐induced visceral hyperalgesia mice

2020 ◽  
Author(s):  
Hanliang Sun ◽  
Yanhan Ma ◽  
Shuhong An ◽  
Zhaojin Wang
Keyword(s):  
Gene Expression ◽  
Mast Cell ◽  
Cell Activity ◽  
Calcitonin Gene Related Peptide ◽  
Visceral Hyperalgesia ◽  
Altered Gene Expression ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Gene Expression Signatures ◽  
Altered Gene

Involvement of spinal calcitonin gene-related peptide in the development of acute visceral hyperalgesia in the rat

2001 ◽  
Vol 13 (3) ◽  
pp. 229-236 ◽  
Author(s):  
J. M. Gschossmann ◽  
S. V. Coutinho ◽  
J. C. Miller ◽  
K. Huebel ◽  
B. Naliboff ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Visceral Hyperalgesia ◽  
Related Peptide ◽  
Calcitonin Gene

The localization of calcitonin gene related peptide (CGRP) receptor in rat stomach, and the role of CGRP on the secretion and gene expression of somatostatin

2000 ◽  
Vol 118 (4) ◽  
pp. A1103
Author(s):  
Kousaku Kawashima ◽  
Shunji Ishihara ◽  
Nobuyuki Moriyama ◽  
Hiroshi Suetsugu ◽  
Hideaki Kazumori ◽  
...  
Keyword(s):  
Gene Expression ◽  
Calcitonin Gene Related Peptide ◽  
Cgrp Receptor ◽  
Rat Stomach ◽  
Related Peptide ◽  
Calcitonin Gene

Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats

1997 ◽  
Vol 273 (1) ◽  
pp. G191-G196 ◽  
Author(s):  
V. Plourde ◽  
S. St-Pierre ◽  
R. Quirion
Keyword(s):  
Acetic Acid ◽  
Visceral Pain ◽  
Intrathecal Administration ◽  
Calcitonin Gene Related Peptide ◽  
Visceral Hyperalgesia ◽  
Afferent Pathways ◽  
Colorectal Distension ◽  
Related Peptide ◽  
Balloon Distension ◽  
Calcitonin Gene

The role of calcitonin gene-related peptide (CGRP) on colorectal distension-induced visceral pain was investigated in conscious rats. Intracolonic administration of acetic acid (0.6%) resulted in a significantly increased number of abdominal contractions in response to colorectal balloon distension from 5.8 +/- 1.2 in controls to 16.6 +/- 1.0 in acetic acid-treated animals (P < 0.05), evidencing sensitization of visceral afferent pathways and subsequently visceral hyperalgesia. This sensitization phenomenon was not observed in animals previously treated with systemic capsaicin. Likewise, in animals not treated with capsaicin, use of an intravenous antagonist for CGRP [human CGRP-(8-37)], completely reversed the sensitizing effects of acetic acid. Furthermore, intravenous administration of CGRP dose dependently increased the number of abdominal contractions in response to colorectal distension from 3.0 +/- 1.1 (CGRP 250 ng) to 17.0 +/- 1.2 (CGRP 500 ng, P < 0.05), as previously observed in acetic acid-treated animals. Finally, intrathecal administration of hCGRP-(8–37) (mid-lumbar) also resulted in a total dose-dependent reversal of CGRP (500 ng) or acetic acid-induced visceral hypersensitivity. These results demonstrate that CGRP plays a major role in this model of visceral afferent nerve sensitization from gastrointestinal origin.

Effects of calcitonin gene-related peptide on somatostatin and gastrin gene expression in rat antrum

1998 ◽  
Vol 73 (2) ◽  
pp. 75-82 ◽  
Author(s):  
Jiayuan Ren ◽  
S.Terence Dunn ◽  
Yanfeng Tang ◽  
Youping Wang ◽  
Jiesheng Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

Involvement of calcitonin gene-related peptide (CGRP) in the development of acute visceral hyperalgesia in the rat

1998 ◽  
Vol 114 ◽  
pp. A757 ◽  
Author(s):  
JM Gschossmann ◽  
JC Miller ◽  
V Plourde ◽  
HC Wong ◽  
JH Walsh ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Visceral Hyperalgesia ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals The Expression of mRNA for Calcitonin Gene-Related Peptide Receptors in a Mucosal Type Mast Cell Line, RBL-2H3

2004 ◽  
Vol 27 (6) ◽  
pp. 896-898 ◽  
Author(s):  
Yuki Kitabatake ◽  
Shunsuke Kawamura ◽  
Masamichi Yamashita ◽  
Kaori Okuyama ◽  
Motoaki Takayanagi ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Receptors ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Mast Cell Line
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