scholarly journals The not‐so‐rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high‐resolution anorectal manometry

2020 ◽  
Author(s):  
Desiree F. Baaleman ◽  
Monica Malamisura ◽  
Marc A. Benninga ◽  
Neetu Bali ◽  
Karla H. Vaz ◽  
...  
Keyword(s):  
High Resolution ◽  
Anal Sphincter ◽  
Anorectal Manometry ◽  
Internal Anal Sphincter ◽  
Internal Anal Sphincter Achalasia

Traditional measures of normal anal sphincter function using high-resolution anorectal manometry (HRAM) in 115 healthy volunteers

2014 ◽  
Vol 26 (5) ◽  
pp. 625-635 ◽  
Author(s):  
E. V. Carrington ◽  
A. Brokjaer ◽  
H. Craven ◽  
N. Zarate ◽  
E. J. Horrocks ◽  
...  
Keyword(s):  
High Resolution ◽  
Healthy Volunteers ◽  
Anal Sphincter ◽  
Anorectal Manometry ◽  
Sphincter Function ◽  
Anal Sphincter Function

Mo2109 Characterization of Transient Anal Sphincter Relaxations (TASRs) Health Using High Resolution Anorectal Manometry: Redefining the Sampling Reflex?

2013 ◽  
Vol 144 (5) ◽  
pp. S-745 ◽  
Author(s):  
Emma V Carrington ◽  
Anthony Hobson ◽  
Charles H. Knowles ◽  
Peter J. Lunniss ◽  
S. Mark Scott
Keyword(s):  
High Resolution ◽  
Anal Sphincter ◽  
Anorectal Manometry

Distribution of Interstitial Cells of Cajal in the Internal Anal Sphincter of Patients With Internal Anal Sphincter Achalasia and Hirschsprung Disease

2003 ◽  
Vol 127 (9) ◽  
pp. 1192-1195 ◽  
Author(s):  
Anna Piaseczna Piotrowska ◽  
Valeria Solari ◽  
Prem Puri
Keyword(s):  
Anal Sphincter ◽  
Internal Anal Sphincter ◽  
Interstitial Cells Of Cajal ◽  
Internal Sphincter ◽  
Smooth Muscles ◽  
Hirschsprung Disease ◽  
Interstitial Cells ◽  
Nerve Fibers ◽  
Internal Anal Sphincter Achalasia ◽  
Cells Of Cajal

Abstract Context.—Interstitial cells of Cajal (ICCs) are pacemaker cells in the smooth muscles of the gut. The internal anal sphincter (IAS) is the most caudal part of gastrointestinal tract. It has the important function of maintaining fecal continence. It has been proposed that ICCs in the IAS mediate the inhibitory innervation of the recto-anal reflexes. Objective.—To investigate the distribution of ICCs in the normal IAS and in the IAS of children diagnosed with internal anal sphincter achalasia (IASA) and Hirschsprung disease (HD). Methods.—At the time of IAS myectomy, specimens of the IAS were taken from 8 patients with IASA, 4 patients with HD, and 4 normal controls. All specimens were examined using anti–c-Kit and antiperipherin antibodies; immunolocalization was detected with light microscopy. Density of the ICCs was graded by computerized image analysis. Results.—There was strong peripherin immunoreactivity in the ganglia cells and nerve fibers in the normal IAS. The number of peripherin-positive nerve fibers was markedly reduced in the IAS in patients with IASA. In HD patients, there was lack of peripherin immunoreactivity in the IAS, but hypertrophic nerve trunks stained strongly. Many c-Kit–positive ICCs were present among the muscle fibers and between the muscle bundles in the normal IAS. In HD and IASA patients, ICCs were absent or markedly reduced. Conclusion.—Altered distribution of ICCs in the internal sphincter in IASA and HD may contribute to motility dysfunction in these patients.

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