scholarly journals Changes in fecal short‐chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome

2020 ◽  
Author(s):  
Magdy El‐Salhy ◽  
Jørgen Valeur ◽  
Trygve Hausken ◽  
Jan Gunnar Hatlebakk
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Fecal Microbiota Transplantation ◽  
Short Chain Fatty Acids ◽  
Fecal Microbiota ◽  
Short Chain ◽  
Irritable Bowel ◽  
Chain Fatty Acids

scholarly journals Fecal Bile Acids and Fecal Short Chain Fatty Acids in Patients with Irritable Bowel Syndrome and Control Volunteers

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Chirag Patel ◽  
Carolyn Lockett ◽  
Huiping Xu ◽  
Andrea Shin
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Organic Acids ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Small Sample ◽  
Short Chain ◽  
Fecal Bile Acids ◽  
Irritable Bowel ◽  
Chain Fatty Acids

Background and Aims: Fecal bile acids (BAs), short chain fatty acids (SCFAs), and gut microbiome may be implicated in irritable bowel syndrome (IBS) pathophysiology. Our aim was to compare fecal organic acids between IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), and controls.   Methods: Stool samples were collected from 17 controls, 5 IBS-C, and 5 IBS-D volunteers during a 4-day high fat diet. Aliquots were stored for future analysis of the fecal microbiota. Fecal SCFA and BA analyses were conducted at the Metabolite Profiling Facility at Purdue University and Laboratory Medicine and Pathology at Mayo Clinic. We compared SCFA and BA levels among groups using the Wilcoxon rank sum test. Gamma and linear regression were used to compare SCFAs and BAs adjusting for age and body mass index (BMI).  Results: Fecal acetate levels (mean+SD, µg/mg) were higher in IBS-C (11.3±7) than in controls (6.1±3.3) or IBS-D (7.7±2), although not statistically significant (p=0.19). Total fecal BAs (median [IQR], %) were higher in IBS-D (675 [484-778]) than in controls (342 [130-640]) or IBS-C (321.5 (34.5-718); however, differences were not significant. No significant differences were observed in BAs or SCFAs between groups in multivariate analyses.  Conclusion: We are unable to show significant differences in organic acid levels in IBS and controls. Lack of association may be due to small sample size. Future investigation of larger patient numbers with incorporation of transit and microbiome analyses may shed further light on the role of organic acids in IBS to identify new biomarkers and treatment targets.

Mo1323 SEX-BASED DIFFERENCES IN FECAL SHORT-CHAIN FATTY ACIDS IN IRRITABLE BOWEL SYNDROME PATINETS AND A SCORECARD TO ASSIST DIAGNOSIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-849-S-850
Author(s):  
Qinghua Sun ◽  
Zuojing Liu ◽  
Lu Zhang ◽  
Lijin Song ◽  
Hui Wei ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Irritable Bowel ◽  
Chain Fatty Acids

scholarly journals Alterations in short-chain fatty acids and serotonin in irritable bowel syndrome: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mei Luo ◽  
Xiaojun Zhuang ◽  
Zhenyi Tian ◽  
Lishou Xiong
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Mean Differences ◽  
Irritable Bowel ◽  
Chain Fatty Acids

Abstract Background Short-chain fatty acids (SCFAs) and serotonin (5-hydroxytryptamine, 5-HT) may be associated with the pathogenesis of irritable bowel syndrome (IBS). There are some reports of alterations in SCFAs and 5-HT in IBS, but their results are inconsistent. We aimed to perform a meta-analysis to assess alterations in SCFAs and 5-HT in IBS patients and their potential role in the abnormal brain-gut-microbiota (BGM) axis. Methods Case–control studies detecting SCFAs and 5-HT in IBS patients were identified from PubMed, Web of Science, Cochrane Library, and Scopus databases to identify relevant articles up to September 2018. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) of SCFAs and 5-HT were calculated by REVIEW MANAGER 5.3 to evaluate the alterations of 5-HT and SCFAs in IBS. Results Five studies on SCFAs and 5 on 5-HT in IBS patients were included. As compared to healthy controls (HCs), the SMDs of 5-HT in IBS patients was 2.35 (95% CI 0.46–4.24) and the SMDs of total SCFAs, acetic acid, propionic acid, and butyric acid in IBS patients were − 0.01 (95% CI − 0.57–0.55), − 0.04 (95% CI − 0.55–0.47), 0.07 (95% CI − 0.45–0.60), and − 0.00 (95% CI − 0.49–0.49), respectively. Conclusions There was an increase in 5-HT in blood of IBS patients, indicating the increased 5-HT in blood may be involved in IBS pathogenesis. However, there were no significant differences in SCFAs in feces between IBS patients and HCs. But the study did not differentiate between subgroups of IBS. These findings might provide insight for future studies of the BGM axis in the pathogenesis of IBS. Mei Luo and Xiaojun Zhuang contributed equally to the writing of this article

scholarly journals Short chain fatty acids mediated flora-host interaction and irritable bowel syndrome

2015 ◽  
Vol 23 (36) ◽  
pp. 5815 ◽  
Author(s):  
Wan-Li Xu ◽  
Gao Lu ◽  
Shi-Jie Liang ◽  
Xiao-Liang Wu ◽  
Li-Xia Pei ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Host Interaction ◽  
Irritable Bowel ◽  
Chain Fatty Acids

scholarly journals Progress in understanding of relationship between short chain fatty acids and irritable bowel syndrome

2021 ◽  
Vol 29 (19) ◽  
pp. 1102-1109
Author(s):  
Lu Hang ◽  
Yan Zhou ◽  
Yang-Yang Meng ◽  
Ya Feng ◽  
Yin-Shu Wang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Irritable Bowel ◽  
Chain Fatty Acids

scholarly journals Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome

Medicine ◽  
2019 ◽  
Vol 98 (7) ◽  
pp. e14513 ◽  
Author(s):  
Qinghua Sun ◽  
Qiong Jia ◽  
Lijin Song ◽  
Liping Duan
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Irritable Bowel ◽  
Chain Fatty Acids
Sign in / Sign up

Export Citation Format

Share Document