Ineffective esophageal motility and bolus clearance. A study with combined high‐resolution manometry and impedance in asymptomatic controls and patients

2020 ◽  
Vol 32 (9) ◽  
Author(s):  
Frank Zerbib ◽  
Ingrid Marin ◽  
Daniel Cisternas ◽  
Luiz Abrahao ◽  
Albis Hani ◽  
...  
Keyword(s):  
High Resolution ◽  
Esophageal Motility ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility

P173 HIGH-RESOLUTION MANOMETRIC FINDINGS AFTER MAGNETIC SPHINCTER AUGMENTATION

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Carlo Galdino Riva ◽  
Stefano Siboni ◽  
Veronica Lazzari ◽  
Marco Sozzi ◽  
Emanuele Asti ◽  
...  
Keyword(s):  
High Resolution ◽  
Esophageal Motility ◽  
Symptom Relief ◽  
Rank Test ◽  
Barium Swallow ◽  
Upper Gastrointestinal Endoscopy ◽  
Magnetic Sphincter Augmentation ◽  
Hrql Score ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility

Abstract Aim The aim of this study was to evaluate esophageal motility before and after Magnetic Sphincter Augmentation (MSA) for medically refractory Gastro-Esophageal Reflux Disease (GERD). Background and Methods MSA (LINX® Reflux Management System) is intended for patients with chronic GERD with incomplete symptom relief from proton-pump inhibitors (PPI) and abnormal acid exposure. A prospectively collected database of patients who underwent MSA between 2007 and 2019 was queried. All patients who completed pre- and post-operative high-resolution manometry (HRM) were included in the study. Additional investigations included Health-Related Quality of Life (GERD-HRQL) questionnaire, Functional Outcome Swallowing Scale (FOSS), upper gastrointestinal endoscopy, barium swallow, and 24-96 hours pH-study. Data were analyzed using Wilcoxon signed rank test and McNemar test. Results Forty-five patients met the inclusion criteria. The median follow-up was 10 months (IQR 6). Compared to baseline, there was a statistically significant reduction in PPI use (p=0.000), rate of heartburn (p=0.000), regurgitation (p=0.008), and extra-esophageal symptoms (p=0.000). Only three (6.7%) patients required dietary changes. The GERD-HRQL score significantly improved (p=0.000). There was a significant increase in the Lower Esophageal Sphincter (LES) competency, including LES length (p=0.004) and Esophago-gastric Contractile Integral ((EGJ-CI) (p=0.000). A significant increase in integrated relaxation pressure (IRP) (p=0.000), mean Distal Contractile Integral (DCI) (p=0.008) and intrabolus pressure (p=0.000) was also found. Thirteen (28.9%) patients presented pre-operative Ineffective Esophageal Motility (IEM) and five of them resolved postoperatively. Two patients (4.4%) developed IEM after surgery: both had IRP and DCI values within normal limits, and one of them complained of dysphagia. However, the GERD-HRQL score recovered in both patients. Conclusion MSA was clinically effective in relieving both typical and atypical GERD symptoms. LES competency increased after MSA. EGJ outflow obstruction was uncommon and not associated with symptoms. Finally, ineffective esophageal motility may reverse to normal after MSA.

Tu1412 IMPACT OF INEFFECTIVE ESOPHAGEAL MOTILITY ON SECONDARY PERISTALSIS IN GERD: STUDIES WITH HIGH RESOLUTION MANOMETRY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1095-S-1096
Author(s):  
Wei-Yi Lei ◽  
Jen-Hung Wang ◽  
Ming-Wun Wong ◽  
Chih-Hsun Yi ◽  
Tso-Tsai Liu ◽  
...  
Keyword(s):  
High Resolution ◽  
Esophageal Motility ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility ◽  
Secondary Peristalsis

scholarly journals High-Resolution Manometry Correlates of Ineffective Esophageal Motility

2012 ◽  
Vol 107 (11) ◽  
pp. 1647-1654 ◽  
Author(s):  
Yinglian Xiao ◽  
Peter J Kahrilas ◽  
Mary J Kwasny ◽  
Sabine Roman ◽  
Zhiyue Lin ◽  
...  
Keyword(s):  
High Resolution ◽  
Esophageal Motility ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility
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