scholarly journals Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice

2020 ◽  
Vol 32 (7) ◽  
Author(s):  
Shingo Takashima ◽  
Fumio Tanaka ◽  
Yunosuke Kawaguchi ◽  
Yuki Usui ◽  
Kosuke Fujimoto ◽  
...  
2019 ◽  
Vol 156 (6) ◽  
pp. S-204
Author(s):  
Shingo Takashima ◽  
Fumio Tanaka ◽  
Koji Otani ◽  
Shuhei Hosomi ◽  
Yasuaki Nagami ◽  
...  

Author(s):  
Lila Simakachorn ◽  
◽  
Pornthep Tanpowpong ◽  
Suwanee Chanprasertyothin ◽  
Supranee Thongpradit ◽  
...  

2018 ◽  
Vol 63 (11) ◽  
pp. 2940-2949 ◽  
Author(s):  
Mariko Hojo ◽  
Takashi Asahara ◽  
Akihito Nagahara ◽  
Tsutomu Takeda ◽  
Kohei Matsumoto ◽  
...  

2021 ◽  
Vol 14 ◽  
pp. 175628482199473
Author(s):  
Kanika Sehgal ◽  
Sahil Khanna

The pathogenesis of Clostridioides difficile infection (CDI) was recognized with its link to the use of antimicrobials. Antimicrobials significantly alter gut microbiota structure and composition, which led to the discovery of the association of this gut perturbation with the development of CDI. A number of factors implicated in its pathogenesis, such as advancing age, proton-pump inhibitors, and gastrointestinal diseases, are linked to gut microbiota perturbations. In an effort to better understand CDI, a multitude of studies have tried to ascertain protective and predictive microbial footprints linked with CDI. It has further been realized that CDI in itself can alter the gut microbiome. Its spore-forming capability poses as an impediment in the management of the infection and contributes to its recurrence. Antibiotic therapies used for its management have also been linked to gut microbiota changes, making its treatment a little more challenging. In an effort to exploit and utilize this association, gut microbial restoration therapies, particularly in the form of fecal microbial transplant, are increasingly being put to use and are proving to be beneficial. In this review, we summarize the association of the gut microbiome and microbial perturbation with initial and recurrent CDI.


2012 ◽  
Vol 42 (7) ◽  
pp. 760-767 ◽  
Author(s):  
Lotte G. van Vlerken ◽  
Ellen J. Huisman ◽  
Bart van Hoek ◽  
Willem Renooij ◽  
Felix W. M. de Rooij ◽  
...  

Gut Microbes ◽  
2017 ◽  
Vol 8 (4) ◽  
pp. 351-358 ◽  
Author(s):  
Floris Imhann ◽  
Arnau Vich Vila ◽  
Marc Jan Bonder ◽  
Ailine G. Lopez Manosalva ◽  
Debby P.Y. Koonen ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sun Min Lee ◽  
Nayoung Kim ◽  
Ryoung Hee Nam ◽  
Ji Hyun Park ◽  
Soo In Choi ◽  
...  

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