scholarly journals Comparison of antegrade continence enema treatment and sacral nerve stimulation for children with severe functional constipation and fecal incontinence

2020 ◽  
Vol 32 (8) ◽  
Author(s):  
Mana H. Vriesman ◽  
Lyon Wang ◽  
Candice Park ◽  
Karen A. Diefenbach ◽  
Marc A. Levitt ◽  
...  
Keyword(s):  
Fecal Incontinence ◽  
Nerve Stimulation ◽  
Sacral Nerve Stimulation ◽  
Functional Constipation ◽  
Antegrade Continence Enema ◽  
Sacral Nerve

Su1647 - Sacral Nerve Stimulation Versus Antegrade Continence Enema Treatment for Children with Intractable Constipation and Fecal Incontinence

2018 ◽  
Vol 154 (6) ◽  
pp. S-561
Author(s):  
Mana H. Vriesman ◽  
Peter L. Lu ◽  
Karen A. Diefenbach ◽  
Seth A. Alpert ◽  
Marc A. Benninga ◽  
...  
Keyword(s):  
Fecal Incontinence ◽  
Nerve Stimulation ◽  
Sacral Nerve Stimulation ◽  
Antegrade Continence Enema ◽  
Sacral Nerve ◽  
Intractable Constipation

scholarly journals Sacral nerve stimulation with appropriate parameters improves constipation in rats by enhancing colon motility mediated via the autonomic-cholinergic mechanisms

2019 ◽  
Vol 317 (5) ◽  
pp. G609-G617 ◽  
Author(s):  
Zhihui Huang ◽  
Shiying Li ◽  
Robert D. Foreman ◽  
Jieyun Yin ◽  
Ning Dai ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Fecal Incontinence ◽  
Nerve Stimulation ◽  
Sacral Nerve Stimulation ◽  
Distal Colon ◽  
Colon Motility ◽  
Rectal Compliance ◽  
Sacral Nerve ◽  
Cholinergic Function ◽  
Colon Transit

Although sacral nerve stimulation (SNS) has been applied for treating constipation, its parameters were adopted from SNS for fecal incontinence, its effects are limited, and mechanisms are largely unknown. We investigated the effects and mechanism of SNS with appropriate parameters on constipation in rats treated with loperamide. First, using rectal compliance as an outcome measure, an experiment was performed to derive effective SNS parameters. Then, a 7-day SNS was performed in rats with constipation induced by loperamide. Autonomic functions were assessed by spectral analysis of heart rate variability (HRV) derived from an electrocardiogram. Serum levels of pancreatic polypeptide (PP), norepinephrine (NE), and acetylcholine (ACh) in colon were assessed. 1) Acute SNS at 5 Hz, 100 µs was found effective in enhancing rectal compliance and accelerating distal colon transit ( P < 0.05 vs. sham SNS). 2) The 7-day SNS normalized loperamide-induced constipation, assessed by the number, weight, and water content of fecal pellets, and accelerated the distal colon transit (29.4 ± 3.7 min with sham SNS vs. 16.4 ± 5.3 min with SNS but not gastric emptying or intestinal transit. 3) SNS significantly increased vagal activity ( P = 0.035) and decreased sympathetic activity ( P = 0.012), assessed by spectral analysis of HRV as well as by the serum PP. 4) SNS increased ACh in the colon tissue; atropine blocked the accelerative effect of SNS on distal colon transit. We concluded that SNS with appropriate parameters improves constipation induced by loperamide by accelerating distal colon motility, mediated via the autonomic-cholinergic function. NEW & NOTEWORTHY Although sacral nerve stimulation (SNS) has been applied for treating constipation, its parameters were adopted from SNS for fecal incontinence, effects are limited, and mechanisms are largely unknown. This paper shows that SNS with appropriate parameters improves constipation induced by loperamide by accelerating distal colon motility mediated via the autonomic-cholinergic function.

Six Years of Experience With Sacral Nerve Stimulation for Fecal Incontinence

2010 ◽  
Vol 53 (4) ◽  
pp. 414-421 ◽  
Author(s):  
Hanne B. Michelsen ◽  
Mark Thompson-Fawcett ◽  
Lilli Lundby ◽  
Klaus Krogh ◽  
Søren Laurberg ◽  
...  
Keyword(s):  
Fecal Incontinence ◽  
Nerve Stimulation ◽  
Sacral Nerve Stimulation ◽  
Years Of Experience ◽  
Sacral Nerve
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