Esophageal mucosal innervation in functional heartburn: Closer to healthy asymptomatic subjects than to non‐erosive reflux disease patients

2019 ◽  
Vol 31 (9) ◽  
Author(s):  
Kornilia Nikaki ◽  
Philip Woodland ◽  
Chung Lee ◽  
Matteo Ghisa ◽  
Carla Marinelli ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Functional Heartburn ◽  
Asymptomatic Subjects ◽  
Mucosal Innervation

scholarly journals Sa1174 – Esophageal Mucosal Innervation in Functional Heartburn is More Similar to Healthy Asymptomatic Subjects Than to Nonerosive Reflux Disease

2019 ◽  
Vol 156 (6) ◽  
pp. S-294
Author(s):  
Kornilia Nikaki ◽  
Philip J. Woodland ◽  
Chung Lee ◽  
Matteo Ghisa ◽  
Carla Marinelli ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Functional Heartburn ◽  
Nonerosive Reflux Disease ◽  
Asymptomatic Subjects ◽  
Mucosal Innervation

scholarly journals Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease

Gut ◽  
2009 ◽  
Vol 58 (9) ◽  
pp. 1185-1191 ◽  
Author(s):  
E Savarino ◽  
D Pohl ◽  
P Zentilin ◽  
P Dulbecco ◽  
G Sammito ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Reflux Disease ◽  
Functional Heartburn

scholarly journals Objective Evidence of Gastro-Esophageal Reflux Disease is Rare in Patients with Autoimmune Gastritis

2021 ◽  
Vol 30 (1) ◽  
pp. 30-36
Author(s):  
Valentina Pilotto ◽  
Gemma Maddalo ◽  
Costanza Orlando ◽  
Matteo Fassan ◽  
Massimo Rugge ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Ph Monitoring ◽  
Acid Reflux ◽  
Serum Biomarkers ◽  
Functional Heartburn ◽  
High Resolution Manometry ◽  
Reflux Symptoms ◽  
Objective Evidence ◽  
Rome Iv

Background and Aims: Patients with autoimmune atrophic gastritis (AAG) often complain of acid reflux symptoms, despite the evidence of hypo-achlorhydria. Rome IV criteria are used to define functional esophageal disorders. Our aim was to characterize gastroesophageal reflux disease (GERD) phenotypes in patients with AAG. Methods: Between 2017-2018, 172 AAG patients were evaluated at Gastro-Oncology outpatient clinic of University of Padua. Of them, 38 patients with reflux symptoms underwent high-resolution manometry (HRM) and multichannel intraluminal impedance-pH monitoring (MII-pH). Seventy-six AAG consecutive patients asymptomatic for gastroesophageal reflux were selected as age and gender matched controls. Serum biomarkers (pepsinogens, gastrin-17 and Helicobacter pylori antibodies), upper endoscopy, histology and clinical data were compared. Results: Out of 38/172 (22%) AAG patients with reflux symptoms, 2/38 had a GERD diagnosis based on abnormal esophageal acid exposure and 6/38 had a major motility disorder (i.e. outflow obstruction). Among the 30/38 patients with normal endoscopic findings, 9/30 had reflux hypersensitivity, 19 functional heartburn, 1 functional globus, 1 functional chest pain according to the Rome IV criteria. Antral atrophy, advanced corpus atrophy and OLGA stage were more frequent in controls than in reflux patients (p=0.01, p=0.031, p=0.01, respectively). No differences were found for serum biomarkers and symptom presentation. Most of the patients received proton pump inhibitors (PPIs) treatment (87%), with a minority (34%) reporting clinical benefit. Conclusions: Reflux symptoms are relatively common in AAG patients, but a firm diagnosis of GERD is rare (5%), whereas most of the patients have a functional disorder. PPI treatment is mostly clinical ineffective and should not be largely indicated.

OC.03.3: FUNCTIONAL HEARTBURN AND NON-EROSIVE REFLUX DISEASE: THE ADDED VALUE OF IMPEDANCE-PH MONITORING TO ROME III CRITERIA

2011 ◽  
Vol 43 ◽  
pp. S123-S124
Author(s):  
E. Savarino ◽  
P. Zentilin ◽  
M. Frazzoni ◽  
E. Marabotto ◽  
G. Sammito ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Ph Monitoring ◽  
Added Value ◽  
Rome Iii Criteria ◽  
Functional Heartburn ◽  
Rome Iii

Tu1855 Expression of Cathepsin-G and Protease Activated Receptor-4 in Erosive and Non-Erosive Reflux Disease in Comparison With Functional Heartburn and Controls

2013 ◽  
Vol 144 (5) ◽  
pp. S-863-S-864
Author(s):  
Daniela Friedrichs ◽  
Arne Kandulski ◽  
Thomas Wex ◽  
Doerthe Kuester ◽  
Peter Malfertheiner
Keyword(s):  
Reflux Disease ◽  
Cathepsin G ◽  
Functional Heartburn
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