Enteric glial cell activation protects enteric neurons from damage due to diabetes in part via the promotion of neurotrophic factor release

2018 ◽  
Vol 30 (10) ◽  
Author(s):  
P. Luo ◽  
D. Liu ◽  
C. Li ◽  
W.‐X. He ◽  
C.‐L. Zhang ◽  
...  
Keyword(s):  
Glial Cell ◽  
Neurotrophic Factor ◽  
Cell Activation ◽  
Enteric Neurons ◽  
Glial Cell Activation ◽  
Enteric Glial Cell ◽  
Factor Release

scholarly journals GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease

2020 ◽  
Vol 9 (2) ◽  
pp. 456 ◽  
Author(s):  
Marcelo Duarte Azevedo ◽  
Sibilla Sander ◽  
Liliane Tenenbaum
Keyword(s):  
Glial Cell ◽  
Glial Cells ◽  
Motor Neurons ◽  
Cell Activation ◽  
De Novo ◽  
Adult Brain ◽  
Enteric Neurons ◽  
Complex Signals ◽  
Glial Cell Activation ◽  
Injured Brain

In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine fashion by forming a complex with the GDNF family receptor α1 (GFRα1), which is mainly expressed by neurons and can act in cis as a membrane-bound factor or in trans as a soluble factor. The GDNF/GFRα1 complex signals through interactions with the “rearranged during transfection” (RET) receptor or via the neural cell adhesion molecule (NCAM) with a lower affinity. GDNF can also signal independently from GFRα1 by interacting with syndecan-3. RET, which is expressed by neurons involved in several pathways (nigro–striatal dopaminergic neurons, motor neurons, enteric neurons, sensory neurons, etc.), could be the main determinant of the specificity of GDNF’s pro-survival effect. In an injured brain, de novo expression of GDNF occurs in glial cells. Neuroinflammation has been reported to induce GDNF expression in activated astrocytes and microglia, infiltrating macrophages, nestin-positive reactive astrocytes, and neuron/glia (NG2) positive microglia-like cells. This disease-related GDNF overexpression can be either beneficial or detrimental depending on the localization in the brain and the level and duration of glial cell activation. Some reports also describe the upregulation of RET and GFRα1 in glial cells, suggesting that GDNF could modulate neuroinflammation.

Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury

2008 ◽  
Vol 431 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Chanhee Park ◽  
Ik-Hyun Cho ◽  
Donghoon Kim ◽  
Eun-Kyeong Jo ◽  
Se-Young Choi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Glial Cell ◽  
Heme Oxygenase ◽  
Cell Activation ◽  
Heme Oxygenase 1 ◽  
Toll Like Receptor ◽  
Glial Cell Activation ◽  
Toll Like Receptor 2

scholarly journals Neuroinflammation and glial cell activation in mental disorders

2020 ◽  
Vol 2 ◽  
pp. 100034 ◽  
Author(s):  
Priscila G.C. Almeida ◽  
João Victor Nani ◽  
Jean Pierre Oses ◽  
Elisa Brietzke ◽  
Mirian A.F. Hayashi
Keyword(s):  
Mental Disorders ◽  
Glial Cell ◽  
Cell Activation ◽  
Glial Cell Activation

scholarly journals Activation of σ1 and σ2 receptors by afobazole increases glial cell survival and prevents glial cell activation and nitrosative stress after ischemic stroke

2016 ◽  
Vol 139 (3) ◽  
pp. 497-509 ◽  
Author(s):  
Christopher Katnik ◽  
Angela Garcia ◽  
Adam A. Behensky ◽  
Ilya E. Yasny ◽  
Alex M. Shuster ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cell Survival ◽  
Glial Cell ◽  
Cell Activation ◽  
Nitrosative Stress ◽  
Glial Cell Activation

scholarly journals Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

2014 ◽  
Vol 11 (1) ◽  
pp. 50 ◽  
Author(s):  
Natalia Yanguas-Casás ◽  
M Barreda-Manso ◽  
Manuel Nieto-Sampedro ◽  
Lorenzo Romero-Ramírez
Keyword(s):  
Animal Model ◽  
Glial Cell ◽  
Cell Activation ◽  
Tauroursodeoxycholic Acid ◽  
Glial Cell Activation

Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination

2017 ◽  
Vol 55 (8) ◽  
pp. 6237-6249 ◽  
Author(s):  
Stefan Esser ◽  
Larissa Göpfrich ◽  
Kai Bihler ◽  
Eugenia Kress ◽  
Stella Nyamoya ◽  
...  
Keyword(s):  
Mouse Model ◽  
Glial Cell ◽  
Cell Activation ◽  
Toll Like Receptor ◽  
Glial Cell Activation ◽  
Toll Like Receptor 2

Aucubin alleviates glial cell activation and preserves dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian mice

Neuroreport ◽  
2018 ◽  
Vol 29 (13) ◽  
pp. 1075-1083 ◽  
Author(s):  
Ying-Li Zhu ◽  
Meng-Fei Sun ◽  
Xue-Bing Jia ◽  
Pei-Hao Zhang ◽  
Yi-Da Xu ◽  
...  
Keyword(s):  
Glial Cell ◽  
Dopaminergic Neurons ◽  
Cell Activation ◽  
Glial Cell Activation

scholarly journals Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players

2017 ◽  
Vol 74 (1) ◽  
pp. 67 ◽  
Author(s):  
Jennifer M. Coughlin ◽  
Yuchuan Wang ◽  
Il Minn ◽  
Nicholas Bienko ◽  
Emily B. Ambinder ◽  
...  
Keyword(s):  
White Matter ◽  
Glial Cell ◽  
Cell Activation ◽  
National Football League ◽  
White Matter Integrity ◽  
Glial Cell Activation
Sign in / Sign up

Export Citation Format

Share Document