Enteric motor dysfunctions in experimental chronic pancreatitis: Alterations of myenteric neurons regulating colonic motility in rats

2018 ◽  
Vol 30 (7) ◽  
pp. e13301 ◽  
Author(s):  
L. Chen ◽  
B. Yu ◽  
D. Luo ◽  
M. Lin
Keyword(s):  
Chronic Pancreatitis ◽  
Colonic Motility ◽  
Myenteric Neurons ◽  
Experimental Chronic Pancreatitis

Immune-mediated experimental chronic pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A720-A720
Author(s):  
K RIACKEHEER ◽  
G SPARMANN ◽  
H KLEINE ◽  
H WEBER ◽  
S LIEBE ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Immune Mediated ◽  
Experimental Chronic Pancreatitis

5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4 receptors in conscious mice

2007 ◽  
Vol 292 (1) ◽  
pp. G419-G428 ◽  
Author(s):  
L. Wang ◽  
V. Martínez ◽  
H. Kimura ◽  
Y. Taché
Keyword(s):  
Motor Function ◽  
Colonic Motility ◽  
Distal Colon ◽  
Nadph Diaphorase ◽  
Maximal Response ◽  
Myenteric Neurons ◽  
Diaphorase Activity ◽  
Colonic Motor ◽  
Different Populations ◽  
Fos Expression

Serotonin [5-hydroxytryptamine (5-HT)] acts as a modulator of colonic motility and secretion. We characterized the action of the 5-HT precursor 5-hydroxytryptophan (5-HTP) on colonic myenteric neurons and propulsive motor activity in conscious mice. Fos immunoreactivity (IR), used as a marker of neuronal activation, was monitored in longitudinal muscle/myenteric plexus whole mount preparations of the distal colon 90 min after an intraperitoneal injection of 5-HTP. Double staining of Fos IR with peripheral choline acetyltransferase (pChAT) IR or NADPH-diaphorase activity was performed. The injection of 5-HTP (0.5, 1, 5, or 10 mg/kg ip) increased fecal pellet output and fluid content in a dose-related manner, with a peak response observed within the first 15 min postinjection. 5-HTP (0.5–10 mg/kg) dose dependently increased Fos expression in myenteric neurons, with a maximal response of 9.9 ± 1.0 cells/ganglion [ P < 0.05 vs. vehicle-treated mice (2.3 ± 0.6 cells/ganglion)]. There was a positive correlation between Fos expression and fecal output. Of Fos-positive ganglionic cells, 40 ± 4% were also pChAT positive and 21 ± 5% were NADPH-diaphorase positive in response to 5-HTP, respectively. 5-HTP-induced defecation and Fos expression were completely prevented by pretreatment with the selective 5-HT4 antagonist RS-39604. These results show that 5-HTP injected peripherally increases Fos expression in different populations of cholinergic and nitrergic myenteric neurons in the distal colon and stimulates propulsive colonic motor function through 5-HT4 receptors in conscious mice. These findings suggest an important role of activation of colonic myenteric neurons in the 5-HT4 receptor-mediated colonic propulsive motor response.

scholarly journals Evaluation of the role of cholinergic and nitrergic myenteric neurons in colonic motility using genetically‐encoded optical tools

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Thomas W. Gould ◽  
Camilla Fedi ◽  
Claire DeAngeli ◽  
Dante J. Heredia
Keyword(s):  
Colonic Motility ◽  
Myenteric Neurons ◽  
Optical Tools

Pentoxifylline has favorable preventive effects on experimental chronic pancreatitis model

2020 ◽  
Vol 55 (2) ◽  
pp. 236-241
Author(s):  
Muhammed Yildirim ◽  
Mustafa Kaplan ◽  
Tolga Duzenli ◽  
Alpaslan Tanoglu ◽  
Zafer Kucukodaci ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Preventive Effects ◽  
Experimental Chronic Pancreatitis

Protective effects of edaravone on experimental chronic pancreatitis induced by dibutyltin dichloride in rats

Pancreatology ◽  
2013 ◽  
Vol 13 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Chun-Hua Zhou ◽  
Lin-Li ◽  
Xiao-Yan Zhu ◽  
Wen-Tang ◽  
Duan-Min Hu ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Protective Effects ◽  
Dibutyltin Dichloride ◽  
Experimental Chronic Pancreatitis

Polyunsatuted phosphatidylcholine effectively reduces collagen deposition in experimental chronic pancreatitis

1998 ◽  
Vol 114 ◽  
pp. A492
Author(s):  
V. Puig-Diví ◽  
X. Molero ◽  
E. Vaquero ◽  
A. Salas ◽  
F. Guarner ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Collagen Deposition ◽  
Experimental Chronic Pancreatitis

Resveratrol Ameliorates the Severity of Fibrogenesis in Mice with Experimental Chronic Pancreatitis

2018 ◽  
Vol 62 (16) ◽  
pp. 1700561 ◽  
Author(s):  
Yixuan Xia ◽  
Hai-Tao Xiao ◽  
Kanglun Liu ◽  
Hong-Jie Zhang ◽  
Siu Wai Tsang
Keyword(s):  
Chronic Pancreatitis ◽  
Experimental Chronic Pancreatitis
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