scholarly journals Effects of naloxegol on whole gut transit in opioid-naïve healthy subjects receiving codeine: A randomized, controlled trial

2018 ◽  
Vol 30 (5) ◽  
pp. e13298 ◽  
Author(s):  
H. Halawi ◽  
P. Vijayvargiya ◽  
I. Busciglio ◽  
I. Oduyebo ◽  
D. Khemani ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Healthy Subjects ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design1,2

2015 ◽  
Vol 102 (3) ◽  
pp. 582-592 ◽  
Author(s):  
Eli Kristin Aadland ◽  
Charles Lavigne ◽  
Ingvild Eide Graff ◽  
Øyvin Eng ◽  
Martine Paquette ◽  
...  
Keyword(s):  
Risk Factors ◽  
Randomized Controlled Trial ◽  
Healthy Subjects ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial

2018 ◽  
Vol 108 (3) ◽  
pp. 485-491 ◽  
Author(s):  
Alonso Romo-Romo ◽  
Carlos A Aguilar-Salinas ◽  
Griselda X Brito-Córdova ◽  
Rita A Gómez-Díaz ◽  
Paloma Almeda-Valdes
Keyword(s):  
Randomized Controlled Trial ◽  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Healthy Subjects ◽  
Controlled Trial ◽  
Insulin Response ◽  
Control Group ◽  
Acute Insulin Response ◽  
Randomized Controlled ◽  
Insulin Response To Glucose

ABSTRACT Background Recently, the absence of metabolic effects from nonnutritive sweeteners has been questioned. Objective The aim of this study was to evaluate the effects of sucralose consumption on glucose metabolism variables. Design We performed a randomized controlled trial involving healthy subjects without comorbidities and with a low habitual consumption of nonnutritive sweeteners (n = 33/group). Methods The intervention consisted of sucralose consumption as 15% of Acceptable Daily Intake every day for 14 d using commercial sachets. The control group followed the same procedures without any intervention. The glucose metabolism variables (insulin sensitivity, acute insulin response to glucose, disposition index, and glucose effectiveness) were evaluated by using a 3-h modified intravenous-glucose-tolerance test before and after the intervention period. Results Individuals assigned to sucralose consumption showed a significant decrease in insulin sensitivity with a median (IQR) percentage change of −17.7% (−29.3% to −1.0%) in comparison to −2.8% (−30.7% to 40.6%) in the control group (P= 0.04). An increased acute insulin response to glucose from 577 mU · L-1· min (350–1040 mU · L-1· min) to 671 mU · L-1· min (376–1010 mU · L-1· min) (P = 0.04) was observed in the sucralose group for participants with adequate adherence. Conclusions Sucralose may have effects on glucose metabolism, and our study complements findings previously reported in other trials. Further studies are needed to confirm the decrease in insulin sensitivity and to explore the mechanisms for these metabolic alterations. This trial was registered at www.clinicaltrials.gov as NCT02589002.

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