scholarly journals Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats

2015 ◽  
Vol 28 (4) ◽  
pp. 522-531 ◽  
Author(s):  
T. Nozu ◽  
S. Miyagishi ◽  
R. Nozu ◽  
K. Takakusaki ◽  
T. Okumura
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Corticotropin Releasing Factor ◽  
Receptor Type ◽  
Dopamine D2

scholarly journals Bradykinin B2 receptor and dopamine D2 receptor cooperatively contribute to the regulation of neutrophil adhesion to endothelial cells*

2018 ◽  
Vol 65 (3) ◽  
pp. 367-375 ◽  
Author(s):  
Anna Niewiarowska-Sendo ◽  
Anna Łabędź-Masłowska ◽  
Andrzej Kozik ◽  
Ibeth Guevara-Lora
Keyword(s):  
Endothelial Cells ◽  
Cell Adhesion ◽  
Dopamine D2 Receptor ◽  
Leukocyte Adhesion ◽  
D2 Receptor ◽  
Protective Role ◽  
Receptor Type ◽  
Cellular Functions ◽  
Stat3 Phosphorylation

Leukocyte adhesion to the vascular endothelium contributes to many immunological and inflammatory disorders. These processes have been shown to be mediated by bradykinin receptor type 2 (B2R) and dopamine receptor type 2 (D2R). In a previous study, we reported the formation of a B2R-D2R heterodimer, possibly altering cellular functions. Hence, in the present study, we examined the effect of co-activation of endothelial cells with B2R and D2R agonists on the interaction of these cells with neutrophils. Bradykinin, the main B2R agonist, significantly increased cell adhesion, and this effect was reversed when the endothelial cells were additionally co-treated with a selective D2R agonist, sumanirole. These results were dependent on the incubation time, showing an opposite tendency after prolonged stimulation. Significant changes in the expression of adhesion proteins, such as E-selectin and intracellular adhesion molecule 1 in endothelial cells were observed. Additionally, the cells preincubated with tumor necrosis factor-a showed decreased cell adhesion and IL-8 release after long incubation with both agonists. The modulation of cell adhesion by D2R and B2R seem to be mediated via STAT3 phosphorylation. In summary, this study demonstrated a protective role of D2R in neutrophil-endothelial cell adhesion induced by bradykinin, especially in cytokine-stimulated endothelial cells.

Effect of amphetamine on dopamine D2 receptor binding in the primate brain with the agonist ligand [11C]MNPA

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S646-S646
Author(s):  
Nicholas Seneca ◽  
Sjoerd Finnema ◽  
Masanori Ichise ◽  
Balazs Gulyas ◽  
Håkan Wikstrom ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Primate Brain
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