Deoxycholic acid induced changes in electrophysiological parameters and macromolecular permeability in murine small intestine with and without functional enteric nervous system plexuses

2014 ◽  
Vol 26 (8) ◽  
pp. 1179-1187 ◽  
Author(s):  
R. A. Forsgård ◽  
R. Korpela ◽  
L. K. Stenman ◽  
P. Österlund ◽  
R. Holma
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Enteric Nervous System ◽  
Deoxycholic Acid ◽  
Murine Small Intestine ◽  
Induced Changes ◽  
Macromolecular Permeability

scholarly journals Dopamine Transporter Genetic Reduction Induces Morpho-Functional Changes in the Enteric Nervous System

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 465
Author(s):  
Silvia Cerantola ◽  
Valentina Caputi ◽  
Gabriella Contarini ◽  
Maddalena Mereu ◽  
Antonella Bertazzo ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Enteric Nervous System ◽  
Dopamine Transporter ◽  
Myenteric Plexus ◽  
Receptor Activation ◽  
D1 Receptor ◽  
Functional Changes ◽  
Neurochemical Coding ◽  
The Impact

Antidopaminergic gastrointestinal prokinetics are indeed commonly used to treat gastrointestinal motility disorders, although the precise role of dopaminergic transmission in the gut is still unclear. Since dopamine transporter (DAT) is involved in several brain disorders by modulating extracellular dopamine in the central nervous system, this study evaluated the impact of DAT genetic reduction on the morpho-functional integrity of mouse small intestine enteric nervous system (ENS). In DAT heterozygous (DAT+/−) and wild-type (DAT+/+) mice (14 ± 2 weeks) alterations in small intestinal contractility were evaluated by isometrical assessment of neuromuscular responses to receptor and non-receptor-mediated stimuli. Changes in ENS integrity were studied by real-time PCR and confocal immunofluorescence microscopy in longitudinal muscle-myenteric plexus whole-mount preparations (). DAT genetic reduction resulted in a significant increase in dopamine-mediated effects, primarily via D1 receptor activation, as well as in reduced cholinergic response, sustained by tachykininergic and glutamatergic neurotransmission via NMDA receptors. These functional anomalies were associated to architectural changes in the neurochemical coding and S100β immunoreactivity in small intestine myenteric plexus. Our study provides evidence that genetic-driven DAT defective activity determines anomalies in ENS architecture and neurochemical coding together with ileal dysmotility, highlighting the involvement of dopaminergic system in gut disorders, often associated to neurological conditions.

Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine

2003 ◽  
Vol 459 (1) ◽  
pp. 27-39 ◽  
Author(s):  
Sumei Liu ◽  
Hong-Zhen Hu ◽  
Chuanyun Gao ◽  
Na Gao ◽  
Guodu Wang ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Guinea Pig ◽  
Enteric Nervous System ◽  
Cysteinyl Leukotrienes ◽  
Guinea Pig Stomach

Effects of optogenetic activation of the enteric nervous system on gastrointestinal motility in mouse small intestine

2020 ◽  
Vol 229 ◽  
pp. 102733
Author(s):  
Nick J. Spencer ◽  
Lee Travis ◽  
Tim Hibberd ◽  
Nigel Kelly ◽  
Jing Feng ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Enteric Nervous System ◽  
Gastrointestinal Motility ◽  
Mouse Small Intestine

P2X7 receptors in the enteric nervous system of guinea-pig small intestine

2001 ◽  
Vol 440 (3) ◽  
pp. 299-310 ◽  
Author(s):  
Hong-Zhen Hu ◽  
Na Gao ◽  
Zhong Lin ◽  
Chuanyun Gao ◽  
Sumei Liu ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Guinea Pig ◽  
Enteric Nervous System ◽  
P2x7 Receptors

Morphological analysis of the relation between immunoglobulin A production in the small intestine and the enteric nervous system

2005 ◽  
Vol 381 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Tatsuya Hisajima ◽  
Yoshitsugu Kojima ◽  
Akira Yamaguchi ◽  
Richard C. Goris ◽  
Kengo Funakoshi
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Enteric Nervous System ◽  
Morphological Analysis ◽  
Immunoglobulin A
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