Mechanisms of action of otilonium bromide (OB) in human cultured smooth muscle cells and rat colonic strips

2013 ◽  
Vol 25 (12) ◽  
pp. e803-e812 ◽  
Author(s):  
M. Martínez-Cutillas ◽  
V. Gil ◽  
D. Gallego ◽  
N. Mañé ◽  
M. T. Martín ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanisms Of Action ◽  
Cultured Smooth Muscle Cells

Autocrine Induction of DNA Synthesis by Mechanical Injury of Cultured Smooth Muscle Cells

1996 ◽  
Vol 16 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Federico Calara ◽  
Sean Ameli ◽  
Anna Hultgårdh-Nilsson ◽  
Bojan Cercek ◽  
Joel Kupfer ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Dna Synthesis ◽  
Muscle Cells ◽  
Mechanical Injury ◽  
Cultured Smooth Muscle Cells

Abnormal Deposition of Extracellular Matrix Proteins by Cultured Smooth Muscle Cells from Human Varicose Veins

1998 ◽  
Vol 35 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Patricia Sansilvestri-Morel ◽  
Isabelle Nonotte ◽  
Marie-Pierre Fournet-Bourguignon ◽  
Alain Rupin ◽  
Jean-Noël Fabiani ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Varicose Veins ◽  
Extracellular Matrix Proteins ◽  
Muscle Cells ◽  
Matrix Proteins ◽  
Cultured Smooth Muscle Cells

An ATP-sensitive conductance in cultured smooth muscle cells from pregnant rat myometrium

1989 ◽  
Vol 257 (2) ◽  
pp. C297-C305 ◽  
Author(s):  
E. Honore ◽  
C. Martin ◽  
C. Mironneau ◽  
J. Mironneau
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Voltage Clamp ◽  
Free Acid ◽  
Muscle Cells ◽  
Monovalent Cation ◽  
Acid Form ◽  
Pregnant Rat ◽  
Free Acid Form ◽  
Cultured Smooth Muscle Cells

The whole cell voltage-clamp technique was used to study the effects of extracellular ATP in cultured smooth muscle cells isolated from pregnant rat myometrium. An inward current was elicited by ATP (IATP) in cells held at -70 mV under voltage clamp. The amplitude of IATP was reduced by estrogen pretreatment and by the end of pregnancy. IATP not only did not undergo any desensitization but showed facilitation. The current-voltage relationship of IATP was linear and reversed close to 0 mV. Changing the sodium electrochemical gradient by decreasing extracellular or intracellular sodium resulted in a linear relationship between the reversal potential of IATP and Na equilibrium potential that, however, differed from the predicted curve for a purely sodium conductance. The conductance activated by ATP was monovalent cation selective with little discrimination between potassium, cesium, and sodium ions. IATP was depressed by divalent cations, and the rank order of potency was Co greater than Mg greater than Ca greater than Ba, suggesting that the free-acid form of ATP was the effective ligand. Adenosine, AMP, and ADP were ineffective in eliciting IATP, whereas ATP gamma S and alpha,beta-methylene ATP were capable of mimicking the effects of ATP, although they were less potent. These results are consistent with the free-acid form of ATP activating a monovalent cation-selective and estrogen-sensitive conductance in myometrium.

scholarly journals The Effect of Vitamin B6 Antagonists on the Cultured Smooth Muscle Cells from Fetal Bovine Aorta

1984 ◽  
Vol 12 (5) ◽  
pp. 1129-1132
Author(s):  
Kazuaki SHIBATA ◽  
Michitaka NAITO ◽  
Kan-ichi ASAI ◽  
Yoshio IWATA ◽  
Fumio KUZUYA
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Vitamin B ◽  
Fetal Bovine ◽  
Cultured Smooth Muscle Cells
Sign in / Sign up

Export Citation Format

Share Document