Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms

2013 ◽  
Vol 25 (3) ◽  
pp. e224-e232 ◽  
Author(s):  
E. A. Olausson ◽  
C. Brock ◽  
A. M. Drewes ◽  
H. Grundin ◽  
M. Isaksson ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Gastrointestinal Symptoms ◽  
Patients With Diabetes ◽  
Upper Gastrointestinal Symptoms ◽  
Radiopaque Markers ◽  
Upper Gastrointestinal

A longitudinal study of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus

2002 ◽  
Vol 113 (6) ◽  
pp. 449-455 ◽  
Author(s):  
Karen L Jones ◽  
Antonietta Russo ◽  
Melanie K Berry ◽  
Julie E Stevens ◽  
Judith M Wishart ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Longitudinal Study ◽  
Gastric Emptying ◽  
Gastrointestinal Symptoms ◽  
Patients With Diabetes ◽  
Upper Gastrointestinal Symptoms ◽  
Upper Gastrointestinal

scholarly journals Gastroparesis: Prevalence, Clinical Significance and Treatment

2001 ◽  
Vol 15 (12) ◽  
pp. 805-813 ◽  
Author(s):  
Michael Horowitz ◽  
Yu-Chung Su ◽  
Christopher K Rayner ◽  
Karen L Jones
Keyword(s):  
Diabetes Mellitus ◽  
Gastric Emptying ◽  
Blood Glucose Control ◽  
Gastrointestinal Symptoms ◽  
Oral Drug ◽  
Patients With Diabetes ◽  
Upper Gastrointestinal Symptoms ◽  
Potential Impact ◽  
Direct Outcome

The application of novel techniques to quantify gastric motor function and gastric emptying has yielded important insights into the prevalence, pathogenesis and clinical sequelae of gastroparesis. Both acute and chronic gastroparesis occur frequently; gastric emptying of solids is delayed in 30% to 50% of patients with diabetes mellitus, functional dyspepsia and gastroesophageal reflux disease. While many patients with gastroparesis experience upper gastrointestinal symptoms that adversely affect quality of life, the concept that symptoms are inevitably the direct outcome of delay in gastric emptying is now recognized to be overly simplistic. In contrast, the potential impact of gastroparesis on oral drug absorption and blood glucose control in patients with diabetes mellitus has probably been underestimated. While the use of prokinetic drugs (cisapride, domperidone, metoclopramide and erythromycin) forms the mainstay of therapy in symptomatic patients with gastroparesis, a number of novel pharmacological therapies are being evaluated, and preliminary studies using gastric pacing show promise.

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