The MIXED framework: A novel approach to evaluating mixed-methods rigor

2017 ◽  
Vol 24 (4) ◽  
pp. e12189 ◽  
Author(s):  
Ann L. Eckhardt ◽  
Holli A. DeVon
Keyword(s):  
Mixed Methods ◽  
Novel Approach ◽  
Mixed Framework

A novel approach to increase physical activity in older adults in the community using citizen science: a mixed-methods study

2019 ◽  
Vol 64 (5) ◽  
pp. 669-678 ◽  
Author(s):  
Anja Frei ◽  
Kaba Dalla Lana ◽  
Thomas Radtke ◽  
Emily Stone ◽  
Nevil Knöpfli ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Mixed Methods ◽  
Citizen Science ◽  
Mixed Methods Study ◽  
Novel Approach

Assessing Residents’ Place Attachment to the Guatemalan Maya Landscape Through Mixed Methods Photo Elicitation

2019 ◽  
Vol 14 (3) ◽  
pp. 379-402
Author(s):  
Deidre M. Peroff ◽  
Duarte B. Morais ◽  
Erin Seekamp ◽  
Erin Sills ◽  
Tim Wallace
Keyword(s):  
Mixed Methods ◽  
Multidimensional Scaling ◽  
Place Attachment ◽  
Language Barriers ◽  
Place Identity ◽  
Photo Elicitation ◽  
Qualitative Investigation ◽  
Novel Approach ◽  
Place Dependence ◽  
Emerging Themes

We developed mixed methods photo elicitation to mitigate cultural and language barriers and to acquire deeper understandings of indigenous participants’ place attachment. We define mixed methods photo elicitation to integrate quantitative rankings of photos with qualitative induction of the meanings ascribed to the photos. Multidimensional scaling is used to thematically analyze the resulting photo clusters in relation to qualitative investigation of photo meanings. We also introduce a novel approach to a mixed methods joint display, which was used to visualize emerging themes and reveal how quantitative and qualitative findings are integrated. Reacting to a collection of landscape photographs endemic to rural Guatemala, indigenous farmers expressed place dependence to landscapes for economic and noneconomic reasons, and place identity for sociocultural reasons.

scholarly journals Using Text Messaging, Social Media, and Interviews to Understand What Pregnant Youth Think About Weight Gain During Pregnancy (Preprint)

2018 ◽  
Author(s):  
Melissa DeJonckheere ◽  
Lauren P Nichols ◽  
VG Vinod Vydiswaran ◽  
Xinyan Zhao ◽  
Kevyn Collins-Thompson ◽  
...  
Keyword(s):  
Social Media ◽  
Mixed Methods ◽  
Weight Gain ◽  
Language Processing ◽  
Text Messaging ◽  
Text Message ◽  
Novel Approach ◽  
Semistructured Interviews ◽  
Mother And Child ◽  
Weight Gain During Pregnancy

BACKGROUND The majority of pregnant youth gain more weight than recommended by the National Academy of Medicine guidelines. Excess weight gain during pregnancy increases the risk of dangerous complications during delivery, including operative delivery and stillbirth, and contributes to the risk of long-term obesity in both mother and child. Little is known regarding youth’s perceptions of and knowledge about weight gain during pregnancy. OBJECTIVE The aim of this study was to describe the feasibility and acceptability of 3 novel data collection and analysis strategies for use with youth (social media posts, text message surveys, and semistructured interviews) to explore their experiences during pregnancy. The mixed-methods analysis included natural language processing and thematic analysis. METHODS To demonstrate the feasibility and acceptability of this novel approach, we used descriptive statistics and thematic qualitative analysis to characterize participation and engagement in the study. RESULTS Recruitment of 54 pregnant women aged between 16 and 24 years occurred from April 2016 to September 2016. All participants completed at least 1 phase of the study. Semistructured interviews had the highest rate of completion, yet all 3 strategies were feasible and acceptable to pregnant youth. CONCLUSIONS This study has described a novel youth-centered strategy of triangulating 3 sources of mixed-methods data to gain a deeper understanding of a health behavior phenomenon among an at-risk population of youth.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Determining Emotional Tone and Verbal Behavior in Patients With Tinnitus and Hyperacusis: An Exploratory Mixed-Methods Study

2019 ◽  
Vol 28 (3) ◽  
pp. 660-672
Author(s):  
Suzanne H. Kimball ◽  
Toby Hamilton ◽  
Erin Benear ◽  
Jonathan Baldwin
Keyword(s):  
Mixed Methods ◽  
Verbal Behavior ◽  
Coping Strategies ◽  
Mixed Methods Study ◽  
Self Report ◽  
Anxiety And Depression ◽  
Negative Consequences ◽  
Emotional Tone ◽  
Explanatory Mixed Methods ◽  
Quantitative Results

Purpose The purpose of this study was to evaluate the emotional tone and verbal behavior of social media users who self-identified as having tinnitus and/or hyperacusis that caused self-described negative consequences on daily life or health. Research Design and Method An explanatory mixed-methods design was utilized. Two hundred “initial” and 200 “reply” Facebook posts were collected from members of a tinnitus group and a hyperacusis group. Data were analyzed via the LIWC 2015 software program and compared to typical bloggers. As this was an explanatory mixed-methods study, we used qualitative thematic analyses to explain, interpret, and illustrate the quantitative results. Results Overall, quantitative results indicated lower overall emotional tone for all categories (tinnitus and hyperacusis, initial and reply), which was mostly influenced by higher negative emotion. Higher levels of authenticity or truth were found in the hyperacusis sample but not in the tinnitus sample. Lower levels of clout (social standing) were indicated in all groups, and a lower level of analytical thinking style (concepts and complex categories rather than narratives) was found in the hyperacusis sample. Additional analysis of the language indicated higher levels of sadness and anxiety in all groups and lower levels of anger, particularly for initial replies. These data support prior findings indicating higher levels of anxiety and depression in this patient population based on the actual words in blog posts and not from self-report questionnaires. Qualitative results identified 3 major themes from both the tinnitus and hyperacusis texts: suffering, negative emotional tone, and coping strategies. Conclusions Results from this study suggest support for the predominant clinical view that patients with tinnitus and hyperacusis have higher levels of anxiety and depression than the general population. The extent of the suffering described and patterns of coping strategies suggest clinical practice patterns and the need for research in implementing improved practice plans.

Abstract #709: E-Consults: A Novel Approach to Increase Access to Subspecialty Care in Endocrinology

2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  
Novel Approach

Monitoring von Pflegekontextfaktoren – Erste deskriptive Studienresultate einer Querschnittserhebung der schweizerischen DRG Begleitforschung Pflege vor Einführung der SwissDRG

Pflege ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 93-107 ◽  
Author(s):  
Michael Kleinknecht-Dolf ◽  
Elisabeth Spichiger ◽  
Irena Anna Frei ◽  
Marianne Müller ◽  
Jacqueline S. Martin ◽  
...  
Keyword(s):  
Mixed Methods ◽  
Mixed Methods Design

Hintergrund: Mit der Einführung der DRG-basierten Finanzierung erhalten Spitäler einen kleineren finanziellen Spielraum, was Prozessoptimierungen notwendig macht. Internationale Erfahrungen zeigen, dass solche Restrukturierungen Einfluss auf für die Pflege notwendige Kontextfaktoren haben können. Dadurch können auch Pflegequalität und Patientensicherheit beeinträchtigt werden. Ziel: Ziel der «DRG Begleitforschung Pflege» ist, ein Monitoringmodell samt dazugehörenden Instrumenten zur kontinuierlichen Überwachung des Einflusses der DRG-Finanzierung auf zentrale Pflegekontextfaktoren zu entwickeln. Methode: Die vorliegenden deskriptiven quantitativen Resultate wurden im Rahmen der in einem Mixed-Methods-Design durchgeführten Untersuchung mittels einer Online-Befragung erhoben, an der sich Pflegefachpersonen aus fünf Spitälern beteiligten. Ergebnisse: Die Resultate zeigen, dass die untersuchten Pflegekontextfaktoren «Komplexität der Pflege», «Arbeitsumgebungsqualität», «Führungsverhalten», «Moralischer Stress» und «Zufriedenheit mit der Arbeitsstelle» in allen Fachbereichen hinsichtlich der Arbeitsumgebung und Leistungserbringung der Pflege relevant sind. Es lassen sich Muster erkennen, die im Einklang mit der Literatur stehen, und die Hinweise auf die im Modell angenommenen Beziehungen zwischen diesen Kontextfaktoren geben. Schlussfolgerungen: Die Studie hat einerseits für die beteiligten Betriebe nützliche Daten geliefert, auf deren Basis sie Maßnahmen zur Sicherung der Qualität und Entwicklung der Pflege diskutieren können, andererseits konnten wichtige Informationen zur Weiterentwicklung des Modells und zu den eingesetzten Instrumenten gesammelt werden.

Interprofessionelle Zusammenarbeit Pflegefachpersonen und Ärzteschaft

Pflege ◽  
2017 ◽  
Vol 30 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Marianne Schärli ◽  
Rita Müller ◽  
Jacqueline S. Martin ◽  
Elisabeth Spichiger ◽  
Rebecca Spirig
Keyword(s):  
Mixed Methods ◽  
Mixed Methods Design ◽  
Interprofessionelle Zusammenarbeit

Zusammenfassung. Hintergrund: Im klinischen Alltag stellt die interprofessionelle Zusammenarbeit zwischen Pflegefachpersonen und Ärzt(inn)en immer wieder eine Herausforderung dar. Quantitative oder qualitative Studien haben das Ziel, Erkenntnisse zu einer verbesserten Zusammenarbeit aufzuzeigen. Diese Erkenntnisse sind jedoch aus methodischen Gründen oft begrenzt. Ziel: Mittels Triangulation quantitativer und qualitativer Daten beschreibt diese Studie die interprofessionelle Zusammenarbeit aus Sicht der Pflegefachpersonen. Methode: Die Datenerhebung erfolgte in einem Mixed Methods-Design im Rahmen der interprofessionellen Sinergia DRG-Begleitforschung. Zunächst erfolgte eine separate Analyse der quantitativen und qualitativen Daten. Durch die Triangulation entstand in vier Schritten eine „Meta-Matrix“. Ergebnisse: Die „Meta-Matrix“ bildet alle relevanten quantitativen und qualitativen Ergebnisse sowie ihre Zusammenhänge modellähnlich auf einer Seite ab. Die Relevanz, die Einflussfaktoren sowie die Folgen der interprofessionellen Zusammenarbeit für Mitarbeitende, Patient(inn)en, Angehörige und Systeme werden deutlich. Schlussfolgerung: Die interprofessionelle Zusammenarbeit aus Sicht der Pflegefachpersonen in fünf Spitälern wird erstmals umfassend in einer „Meta-Matrix“ aufgezeigt. Die Folgen ungenügender Zusammenarbeit zwischen Pflegefachpersonen und Ärzt(inn)en sind beträchtlich, weshalb in interprofessionelle Konzepte investiert werden muss. Aus der „Meta-Matrix“ ist ersichtlich, welche Faktoren für die interprofessionelle Zusammenarbeit hinderlich bzw. förderlich sind.

Sign in / Sign up

Export Citation Format

Share Document