Relationships between depression, family function, physical symptoms, and illness uncertainty in female patients with chronic kidney disease

2020 ◽  
Vol 22 (3) ◽  
pp. 548-556
Author(s):  
Oksoo Kim ◽  
Eun Yi Yeom ◽  
Hae Ok Jeon
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Physical Symptoms ◽  
Illness Uncertainty ◽  
Family Function ◽  
Female Patients

scholarly journals Correlation of Radiomorphometric Indices of the Mandible and Biochemical Parameters in Patients with Secondary Hyperparathyroidism Due to Chronic Kidney Disease

2019 ◽  
Vol 13 (03) ◽  
pp. 303-309 ◽  
Author(s):  
Stenio Medeiros Queiroz ◽  
Ana Luiza Dias Leite De Andrade ◽  
Patrícia Teixeira De Oliveira ◽  
Paulo Raphael Leite Maia ◽  
Ângelo Giuseppe Roncalli Da Costa Oliveira ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Trabecular Bone ◽  
Biochemical Parameters ◽  
Alveolar Bone ◽  
Mental Foramen ◽  
Mineral And Bone Disorder ◽  
Male And Female ◽  
Significance Level ◽  
Female Patients

Abstract Objective The aim was to correlate radiomorphometric indices and biochemical analyses as an auxiliary method in bone evaluation in male and female patients with chronic kidney disease–mineral and bone disorder (CKD-MBD) and controls. Materials and Methods Nine radiomorphometric indices and four biochemical parameters were obtained: mental index (MI), height at the mental foramen, total mandibular height (THM), panoramic mandibular index (PMI), original height of the mandible, alveolar bone resorption, distance from the mental foramen to the alveolar bone crest (MF-ABC), mandibular cortical index (MCI), trabecular bone pattern, parathyroid hormone (PTH), calcium (Ca), phosphorus (P), and Ca × P product (Ca × P).Statistical Analysis The Mann–Whitney U-test, chi-squared test, and Spearman’s correlation were applied at a significance level of 95%. Results There was a moderate negative and significant correlation between MI, PMI, and PTH in female patients with CKD-MBD as well as between THM, MF-ABC, and Ca × P. The MCI and trabecular bone pattern indicated altered bone quality in male patients. Conclusions The radiomorphometric evaluation was an auxiliary, noninvasive method to detect possible alterations in the cortex and mandibular bone trabeculation in male and female patients with CKD-MBD.

scholarly journals The Enormity of Chronic Kidney Disease in Nigeria: The Situation in a Teaching Hospital in South-East Nigeria

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Ifeoma I. Ulasi ◽  
Chinwuba K. Ijoma
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
Teaching Hospital ◽  
Dialysis Unit ◽  
Female Patients ◽  
Prohibitive Cost ◽  
Stage Renal Disease ◽  
The Impact ◽  
Esrd Patients

Background. The magnitude of the problem of chronic kidney disease (CKD) is enormous, and the prevalence keeps rising. To highlight the burden of CKD in developing countries, the authors looked at end-stage renal disease (ESRD) patients seen at the University of Nigeria Teaching Hospital (UNTH), Enugu, South-East Nigeria.Method. ESRD patients seen from 01/05/1990 to 31/12/2003 were recruited. Records from A&E Department, medical-out-patients, wards and dialysis unit were used.Results. A total of 1001 male versus 537 female patients were reviewed. About 593 male versus 315 female patients had haemodialysis. The mean age was years and 86.5% were <60 years. Primary renal disease could not be determined in 51.6% while hypertension and glomerulonephritis accounted for −17.2% and 14.6%, respectively. Death from renal causes constituted 22.03% of medical deaths.Conclusion. The prognosis for CKD patients in Nigeria is abysmal. Only few patients had renal-replacement-therapy (RRT). The prohibitive cost precludes many patients. This underscores the need for preventive measures to reduce the impact of CKD in the society.

scholarly journals Correlation Between Thyroid Autoantibodies and Cardiovascular Disease in Patients With Stages 3-5 Chronic Kidney Disease

2021 ◽  
Author(s):  
Weicheng Xu ◽  
Shiyi Liang ◽  
Ge qian ◽  
Chijian Li ◽  
Yuxiang Huang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Mitral Valve ◽  
Kidney Disease ◽  
Flow Velocity ◽  
Mitral Annulus ◽  
Thyroid Autoantibodies ◽  
Female Patients ◽  
Early Diastole ◽  
Mitral Annulus Velocity

Abstract Background: Chronic kidney disease (CKD) interacts with thyroid disease and cardiovascular disease (CVD). Our research aimed to analyze the correlation between echocardiographic parameters E / A, E / E ', E' / A ', LVEF and thyroid autoantibodies, and evaluate the role of thyroid autoimmunity in the development of CVD in patients with stages 3-5 CKD.Methods: The patients who were diagnosed as stages 3-5 CKD in our department from January 2015 to May 2019 were recruited. We collected the routine medical history, general clinical data, and laboratory test index of patients. Echocardiography is performed by a trained echocardiographer to measure mitral valve blood flow velocity (E) in early diastole and Mitral valve flow velocity (A), E / A ratio, mitral annulus velocity (E ') in early diastole, mitral annulus velocity (A') in end-diastole, E / E 'ratio, and E' / A ' ratio. The SPSS 22.0 statistical software was used to analyze the data.Results: A total of 1164 patients with stages 3-5 CKD were included. Thyroglobulin antibody (TGAb) was negatively correlated with eGFR (r = -0.287, P <0.05). Thyrotropin receptor antibody (TRAb) was significantly positively correlated with CRP (r = 0.206, P <0.001). The titers of TPOAb and TGAb in male diabetic patients were higher (r = 0.137, P = 0.023; r = 0.159, P = 0.011). In female patients, both TPOAb and TGAb are significantly negatively correlated with HGB (r = -0.213, P = 0.018; r = -0.188, P = 0.019). The E / E’ of patients with TPOAb positive was higher (r = 0.181, P ＜ 0.001). The LVEF in patients with TPOAb positive were higher (r = 0.159, P = 0.007). In addition, LVEF was significantly negatively correlated with TRAb (r = -0.112, P = 0.026).Conclusion: The prevalence of AITD in stages 3-5 CKD gradually increases with the decline of renal function, and the titers of TPOAb and TGAb also gradually increase. In patients with stages 3-5 CKD, AITD may accelerate the incidence of CVD in CKD patients by affecting TG levels, accelerating the occurrence of anemia, and promoting the micro-inflammation. Female patients with high titers of TPOAb and TGAb should be paid more attention. The average E/E' of patients with stage 5 CKD was 16. Women with low FT3 and TPOAb positive maybe more likely to develop diastolic heart failure.

scholarly journals Sex Differences in Patients With Non-dialysis Dependent Chronic Kidney Disease on Serum Cytokines

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1120-1120
Author(s):  
Maria Inês Barreto Silva ◽  
Jenneffer Rayane Braga Tibaes ◽  
Márcia Klein ◽  
Caroline Richard
Keyword(s):  
Chronic Kidney Disease ◽  
Body Composition ◽  
Sex Differences ◽  
Kidney Disease ◽  
Fat Mass ◽  
High Fat ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Male And Female ◽  
Female Patients

Abstract Objectives Cardiovascular (CV) mortality is higher in male compared to female patients with chronic kidney disease (CKD), but biological mechanisms for sex-specific differences are not established. Inflammation and high body fat are both associated with the development of CKD and CV diseases. Yet, little is known about the relationship between sex, body composition, and inflammation in CKD patients. The purpose of this study was to examine cytokines differences between male and female patients with CKD according to body composition. Methods This is a single center, cross-sectional study of patients with non-dialysis dependent CKD stages 3–5. Body composition was assessed by dual energy x-ray absorptiometry. Glomerular filtration rate (eGFR) was estimated by the CKD-EPI equation. Cytokines were measured using an ELISA multiplex assay kit for interleukin (IL) 4, IL6, IL8, IL10, IL12p70, IL17, monocyte chemoattractant protein-1, tumour necrosis factor alpha (TNFɑ), and interferon gamma (IFNγ). High fat mass and low appendicular muscle mass (ASM) was defined for females and males, respectively as ≥32%, ≥25%; and &lt;20 kg, &lt;15 kg. Results  Patients with CKD (n = 167; 53.3%males) aged 60.4 ± 11.3 years, eGFR 30.9 ± 30.2 mL/min, and BMI 26.7 ± 5.0 kg/m2 were included. Age, eGFR, and BMI were similar in both sexes. IL4 was higher in males compared to females (6.5 ± 1.0 vs 3.8 ± 0.9 pg/mL, P = 0.04). After stratifying according to body composition, IL4 remained higher (P = 0.04) in lean males compared to lean females, both with adequate ASM, but this difference disappeared in patients with high fat mass (male versus female). Within sex comparison, females with high fat mass have higher concentrations of IL4, IL8, and IL17 compared with lean females, whereas IL6, IL8, IL17, TNFɑ, and INFγ were higher in males with high fat mass. Conclusions Male and female patients with CKD present a different cytokine profile according to body composition. The higher levels of IL4 observed in males in the present study is consistent with recent evidence that IL4 exerts pro-inflammatory effects on vascular endothelium and is associated with an increase of CV events in CKD. Thus, IL4 might be a cytokine of interest to explain sex differences of CV events and mortality in CKD. Funding Sources Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro.

scholarly journals Comparison of Dipper and Non-Dipper Hypertension Patterns According to Chronic Kidney Disease Stage

2019 ◽  
Vol 1 (2) ◽  
pp. 15-23
Author(s):  
Esra Turan Erkek ◽  
Seydahmet Akin ◽  
Yasemin Ozgur ◽  
Zeki Aydin ◽  
Zerrin Bicik
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Related Factors ◽  
Hypertensive Patients ◽  
Female Patients ◽  
Significant Difference ◽  
Stage 1

Introduction Hypertension is a major cardiovascular risk factor. There is a strong relationship between blood pressure (BP) elevation and stroke, myocardial infarction, heart failure and mortality due to kidney disease. It is known that the loss of the dipping pattern in hypertension is associated with increased target organ damage. In our study, we aimed to investigate the prevalence of dipper hypertension (DHT) and nondipper hypertension (NDHT) and related factors in patients with stage 1 and 2 chronic kidney disease (CKD). Materials and Methods A total of 158 patients diagnosed with stage 1 or stage 2 CKD were included in the study. Demographic characteristics, anthropometric measurements, physical examination findings and laboratory results of the patients were recorded. Ambulatory BP monitoring was performed in all patients. Results Of the 158 patients (female n: 98), 78 (49%) were in the stage 1 CKD group and 80 (51%) were in the stage 2 CKD group. No significant difference was observed in the prevalence of DHT or NDHT between hypertensive patients in the stage 1 and 2 CKD groups. The rate of NDHT was 59.5% (94/158 patients). Female patients had more DHT in the general population and in the stage 1 group than male patients (p=0.05, p=0.01, respectively). Conclusion No significant difference was observed in the prevalence of DHT or NDHT between hypertensive patients in the stage 1 and 2 CKD groups. The prevalence of DHT in female patients was significantly higher in both groups than in men in both groups, but especially in the stage 1 CKD group.

scholarly journals Comparison of Fatty Acid Profiles in a Group of Female Patients with Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS)–Similar Trends of Changes, Different Pathophysiology

2019 ◽  
Vol 20 (7) ◽  
pp. 1719 ◽  
Author(s):  
Małgorzata Szczuko ◽  
Małgorzata Kaczkan ◽  
Arleta Drozd ◽  
Dominika Maciejewska ◽  
Joanna Palma ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Oleic Acid ◽  
Fatty Acid ◽  
Kidney Disease ◽  
Metabolic Pathways ◽  
Kidney Diseases ◽  
Protective Mechanism ◽  
Female Patients ◽  
Epa And Dha

Fatty acid (FA) profiles in the plasma of patients with metabolic syndrome and chronic kidney disease (CKD) seem to be identical despite their different etiology (dietary mistakes vs. cachexia). The aim of this study was to compare both profiles and to highlight the differences that could influence the improvement of the treatment of patients in both groups. The study involved 73 women, including 24 patients with chronic kidney disease treated with haemodialysis, 19 patients with metabolic syndrome (MetS), and 30 healthy women in the control group. A total of 35 fatty acids and derivatives were identified and quantified by gas chromatography. Intensified elongation processes from acid C10:0 to C16:0 were noted in both groups (more intense in MetS), as well as an increased synthesis of arachidonic acid (C20:4n6), which was more intense in CKD. Significant correlations of oleic acid (C18:1n9), gamma linoleic acid (C18:3n6), and docosatetraenoate acid (C22:4n6) with parameters of CKD patients were observed. In the MetS group, auxiliary metabolic pathways of oleic acid were activated, which simultaneously inhibited the synthesis of eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) from alpha lipoic acid (ALA). On the other hand, in the group of female patients with CKD, the synthesis of EPA and DHA was intensified. Activation of the synthesis of oleic acid (C18: 1n9 ct) and trans-vaccinic acid (C18:1) is a protective mechanism in kidney diseases and especially in MetS due to the increased concentration of saturated fatty acid (SFA) in plasma. The cause of the increased amount of all FAs in plasma in the CKD group, especially in the case of palmitic (C16:0) and derivatives stearic (C18:0) acids, may be the decomposition of adipose tissue and the progressing devastation of the organism, whereas, in the MetS group, dietary intake seems to be the main reason for the increase in SFA. Moreover, in MetS, auxiliary metabolic pathways are activated for oleic acid, which cause the simultaneous inhibition of EPA and DHA synthesis from ALA, whereas, in the CKD group, we observe an increased synthesis of EPA and DHA. The higher increase of nervonic acid (C24:1) in CKD suggests a higher degree of demyelination and loss of axons.

scholarly journals Secretory Immunoglobulin a (SigA) Testing in Saliva from End-Stage Patients with Chronic Kidney Disease Undergoing Dialysis Treatment and in Control Healthy Subjects

2020 ◽  
Vol 47 (2) ◽  
pp. 18-21
Author(s):  
A. Nenova-Nogalcheva ◽  
D. Konstantinova ◽  
P. Pechalova
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Immunoglobulin A ◽  
Chronic Dialysis ◽  
Control Group ◽  
Clinical Group ◽  
Dialysis Treatment ◽  
Mean Values ◽  
Female Patients ◽  
End Stage

AbstractThe purpose of the present study was to measure SIgA levels in saliva in control healthy patients and in patients with end-stage chronic kidney disease (CKD) undergoing dialysis treatment.Methods: 90 participants, divided into 2 groups (Clinical Group and Control Group), had their SigA levels measured from a salivary liquid medium using radial Immunodiffusion (or Mancini method). The Clinical Group comprised 70 end-stage CKD patients on chronic dialysis treatment; the Control Group consisted of 20 clinically healthy individuals. SIgA mean values of the participants from the Clinical Group and the Control Group were 161.46 ± 105.76 and 69.70 ± 25.67 mg/l, respectively.Results: SIgA mean levels in female patients from the Clinical group were significantly higher compared to the mean values in male patients (p = 0.004). The SIgA levels in healthy participants from the Control Group did not reveal statistically significant gender-related dependencies (p = 0.699). Statistical correlation between gender and SigA levels was not established for either group. However, a statistically significant positive correlation was found between the duration of the hemodialysis treatment and SIgA levels (r = 0.46, p < 0.001).Conclusion: The results of the SIgA testing for both groups differed statistically. In the Control Group SIgA levels did not prove to be dependent on gender and age, whereas female patients with chronic renal failure exhibited significantly increased SIgA levels. The studies have outlined a tendency towards increasing SIgA levels among younger patients as well as in patients, undergoing chronic dialysis treatment for over 5 years.

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