scholarly journals Intracellular amyloid hypothesis for ultra‐early phase pathology of Alzheimer's disease

2021 ◽  
Vol 41 (2) ◽  
pp. 93-98
Author(s):  
Hitoshi Okazawa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Phase ◽  
Amyloid Hypothesis

Transcranial Doppler Sonography in the Early Phase of Alzheimer's Disease

1992 ◽  
Vol 3 (1) ◽  
pp. 25-31 ◽  
Author(s):  
S. Bressi ◽  
MA. Volontè ◽  
M. Alberoni ◽  
N. Canal ◽  
M. Franceschi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transcranial Doppler ◽  
Early Phase ◽  
Doppler Sonography ◽  
Transcranial Doppler Sonography

scholarly journals pLG72 levels increase in early phase of Alzheimer’s disease but decrease in late phase

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chieh-Hsin Lin ◽  
Chih-Chiang Chiu ◽  
Chiung-Hsien Huang ◽  
Hui-Ting Yang ◽  
Hsien-Yuan Lane
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amino Acid ◽  
Early Phase ◽  
Late Phase ◽  
Acid Oxidase ◽  
Matched Cohort ◽  
Amino Acid Oxidase ◽  
Gender And Age ◽  
Neurodegenerative Dementia

Abstract pLG72, named as D-amino acid oxidase activator (although it is not an activator of D-amino acid oxidase demonstrated by later studies), in mitochondria has been regarded as an important modulator of D-amino acid oxidase that can regulate the N-methyl-D-aspartate receptor (NMDAR). Both oxidative stress in mitochondria and NMDAR neurotransmission play essential roles in the process of neurodegenerative dementia. The aim of the study was to investigate whether pLG72 levels changed with the severity of neurodegenerative dementia. We enrolled 376 individuals as the overall cohort, consisting of five groups: healthy elderly, amnestic mild cognitive impairment [MCI], mild Alzheimer’s disease [AD], moderate AD, and severe AD. pLG72 levels in plasma were measured using Western blotting. The severity of cognitive deficit was principally evaluated by Clinical Dementia Rating Scale. A gender- and age- matched cohort was selected to elucidate the effects of gender and age. pLG72 levels increased in the MCI and mild AD groups when compared to the healthy group. However, pLG72 levels in the moderate and severe AD groups were lower than those in the mild AD group. D-serine level and D- to total serine ratio were significantly different among the five groups. L-serine levels were correlated with the pLG72 levels. The results in the gender- and age- matched cohort were similar to those of the overall cohort. The finding supports the hypothesis of NMDAR hypofunction in early-phase dementia and NMDAR hyperfunction in late-phase dementia. Further studies are warranted to test whether pLG72 could reflect the function of NMDAR.

scholarly journals Reduced memory and executive functioning significantly relates to participation in early phase clinical research in Alzheimer's disease

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Lovingly Park ◽  
Lev Gertsik ◽  
Zyanya Mendoza ◽  
Lydia Morris ◽  
Claudia Aguilar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Executive Functioning ◽  
Clinical Research ◽  
Early Phase

LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

2020 ◽  
Vol 237 (10) ◽  
pp. 3173-3190
Author(s):  
Chia-Hao Fan ◽  
Chia-Wei Lin ◽  
Hei-Jen Huang ◽  
Guey-Jen Lee-Chen ◽  
Ying-Chieh Sun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Phase ◽  
Receptor Agonist ◽  
Trkb Receptor ◽  
Neurotrophic Effect

Neuroinflammation and Alzheimer’s disease: lessons learned from 5-lipoxygenase

2014 ◽  
Vol 5 (3) ◽  
Author(s):  
Yash Joshi ◽  
Domenico Praticò
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Amyloid Beta ◽  
Neuronal Cells ◽  
Lessons Learned ◽  
Brain Inflammation ◽  
Complex Relationship ◽  
Amyloid Hypothesis

AbstractAside from the well-known amyloid beta and tau pathologies found in Alzheimer’s disease (AD), neuroinflammation is a well-established aspect described in humans and animal models of the disease. Inflammatory perturbations are evident not only in neurons, but also in non-neuronal cells and cytokines in the AD brain. Although the amyloid hypothesis implicates amyloid beta (Aβ) as the prime initiator of the AD, brain inflammation in AD has a complex relationship between Aβ and tau. Using our work with the 5-lipoxygenase protein as an example, we suggest that at least in the case of AD, there is an interdependent and not necessarily hierarchical pathological relationship between Aβ, tau and inflammation.

O4-05-05: Modeling familial danish dementia: Implications for the amyloid hypothesis of Alzheimer's disease

2010 ◽  
Vol 6 ◽  
pp. S158-S158
Author(s):  
Janaky Coomaraswamy ◽  
Ellen Kilger ◽  
Heidrun Woelfing ◽  
Claudia Schaefer ◽  
Stephan A. Kaeser ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Hypothesis ◽  
Familial Danish Dementia
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