Delusions and visual hallucinations in a patient with Parkinson's disease with dementia showing pronounced Lewy body pathology in the nucleus basalis of Meynert

2019 ◽  
Vol 39 (4) ◽  
pp. 319-323 ◽  
Author(s):  
Kenji Sakai ◽  
Tokuhei Ikeda ◽  
Chiho Ishida ◽  
Kiyonobu Komai ◽  
Masahito Yamada
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Body ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Visual Hallucinations ◽  
Lewy Body Pathology ◽  
Parkinson’S Disease With Dementia

scholarly journals Damaged fiber tracts of the nucleus basalis of Meynert in Parkinson’s disease patients with visual hallucinations

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Dagmar H. Hepp ◽  
Elisabeth M. J. Foncke ◽  
Henk W. Berendse ◽  
Thomas M. Wassenaar ◽  
Kim T. E. Olde Dubbelink ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Visual Hallucinations ◽  
Fiber Tracts

Oscillatory activity and cortical coherence of the nucleus basalis of Meynert in Parkinson's disease dementia

2018 ◽  
Vol 52 ◽  
pp. 102-106 ◽  
Author(s):  
Muhammad Nazmuddin ◽  
D.L.Marinus Oterdoom ◽  
J. Marc C. van Dijk ◽  
Jonathan C. van Zijl ◽  
Anne K. Kampman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Oscillatory Activity ◽  
Parkinson’S Disease Dementia

scholarly journals A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease

2022 ◽  
Author(s):  
Zhao-Feng Li ◽  
Lei Cui ◽  
Mi-Mi Jin ◽  
Dong-Yan Hu ◽  
Xiao-Gang Hou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Body ◽  
Cultured Cells ◽  
Three Dimensional ◽  
Proteinase K ◽  
All Trans Retinoic Acid ◽  
Lewy Body Pathology ◽  
Rotenone Treatment ◽  
2D And 3D

Parkinson's disease (PD) is featured with α-synuclein-based Lewy body pathology, which however was difficult to observe in conventional two-dimensional (2D) cell culture and even in animal models. We herein aimed to develop a three-dimensional (3D) cellular model of PD to recapitulate the α-synuclein pathologies. All-trans-retinoic acid-differentiated human SH-SY5Y cells and Matrigel were optimized for 3D construction. The 3D cultured cells displayed higher tyrosine hydroxylase expression and improved dopaminergic-like phenotypes than 2D cells as suggested by RNA-sequencing analyses. Multiple forms of α-synuclein, including monomer, low and high molecular weight oligomers, were differentially present in the 2D and 3D cells, but mostly remained unchanged upon the MPP+ or rotenone treatment. Phosphorylated α-synuclein was accumulated and detergent-insoluble α-synuclein fraction was observed in the neurotoxin-treated 3D cells. Importantly, Lewy body-like inclusions were captured in the 3D system, including proteinase K-resistant α-synuclein aggregates, ubiquitin aggregation, β-amyloid and β-sheet protein deposition. The study provides a unique and convenient 3D model of PD which recapitulates critical α-synuclein pathologies and should be useful in multiple PD-associated applications.

Nucleus basalis of Meynert predicts cognition after deep brain stimulation in Parkinson's disease

2022 ◽  
Vol 94 ◽  
pp. 89-95
Author(s):  
Dorothee Kübler ◽  
Sophie Katharina Wellmann ◽  
Jakob Kaminski ◽  
Cornelia Skowronek ◽  
Gerd-Helge Schneider ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Deep Brain

Increased temporal blood flow associated with visual hallucinations in Parkinson's disease with dementia

2008 ◽  
Vol 23 (3) ◽  
pp. 464-465 ◽  
Author(s):  
Hiroshi Kataoka ◽  
Yoshiko Furiya ◽  
Masami Morikawa ◽  
Satoshi Ueno ◽  
Makoto Inoue
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Visual Hallucinations ◽  
Parkinson’S Disease With Dementia
Sign in / Sign up

Export Citation Format

Share Document