Toxic myopathy with multiple deletions in mitochondrial DNA associated with long‐term use of oral anti‐viral drugs for hepatitis B: A case study

2019 ◽  
Vol 39 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Takayuki Fujii ◽  
Kei‐ichiro Takase ◽  
Hiroyuki Honda ◽  
Nobutoshi Kawamura ◽  
Ryo Yamasaki ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Hepatitis B ◽  
Toxic Myopathy

DNMT1 modulation in chronic hepatitis B patients and hypothetic influence on mitochondrial DNA methylation status during long-term nucleo(t)side analogs therapy

2017 ◽  
Vol 89 (7) ◽  
pp. 1208-1214 ◽  
Author(s):  
Giordano Madeddu ◽  
Silvia Ortu ◽  
Giovanni Garrucciu ◽  
Ivana Maida ◽  
Michela Melis ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Methylation Status

scholarly journals Long-term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA

Hepatology ◽  
2009 ◽  
Vol 49 (6) ◽  
pp. 2080-2086 ◽  
Author(s):  
Jung Im Seok ◽  
Dong Kuck Lee ◽  
Chang Hyeong Lee ◽  
Min Su Park ◽  
Sun Young Kim ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Term Therapy ◽  
Long Term Therapy

Caregivers' Perceptions of Speech-Language Pathologist Talk About Child Language and Literacy Disorders

2020 ◽  
Vol 29 (4) ◽  
pp. 2049-2067
Author(s):  
Karmen L. Porter ◽  
Janna B. Oetting ◽  
Loretta Pecchioni
Keyword(s):  
Language And Literacy ◽  
Collective Case Study ◽  
Study Approach ◽  
School Aged Children ◽  
Speech Language Pathologist ◽  
Therapy Goals ◽  
Semistructured Interviews ◽  
Types Of Information

Purpose This study examined caregiver perceptions of their child's language and literacy disorder as influenced by communications with their speech-language pathologist. Method The participants were 12 caregivers of 10 school-aged children with language and literacy disorders. Employing qualitative methods, a collective case study approach was utilized in which the caregiver(s) of each child represented one case. The data came from semistructured interviews, codes emerged directly from the caregivers' responses during the interviews, and multiple coding passes using ATLAS.ti software were made until themes were evident. These themes were then further validated by conducting clinical file reviews and follow-up interviews with the caregivers. Results Caregivers' comments focused on the types of information received or not received, as well as the clarity of the information. This included information regarding their child's diagnosis, the long-term consequences of their child's disorder, and the connection between language and reading. Although caregivers were adept at describing their child's difficulties and therapy goals/objectives, their comments indicated that they struggled to understand their child's disorder in a way that was meaningful to them and their child. Conclusions The findings showed the value caregivers place on receiving clear and timely diagnostic information, as well as the complexity associated with caregivers' understanding of language and literacy disorders. The findings are discussed in terms of changes that could be made in clinical practice to better support children with language and literacy disorders and their families.

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