An autopsy case of neuronal intermediate filament inclusion disease with regard to immunophenotypic and topographical analysis of the neuronal inclusions

Kimiko Inoue; Harutoshi Fujimura; Kayo Ueda; Tsuyoshi Matsumura; Kyoko Itoh; Saburo Sakoda

doi:10.1111/neup.12213

An autopsy case of neuronal intermediate filament inclusion disease with regard to immunophenotypic and topographical analysis of the neuronal inclusions

Neuropathology ◽

10.1111/neup.12213 ◽

2015 ◽

Vol 35 (6) ◽

pp. 545-552

Author(s):

Kimiko Inoue ◽

Harutoshi Fujimura ◽

Kayo Ueda ◽

Tsuyoshi Matsumura ◽

Kyoko Itoh ◽

...

Keyword(s):

Intermediate Filament ◽

Autopsy Case ◽

Neuronal Inclusions ◽

Topographical Analysis

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An autopsy case report of neuronal intermediate filament inclusion disease presenting with predominantly upper motor neuron features

Neuropathology ◽

10.1111/neup.12741 ◽

2021 ◽

Author(s):

Aya Murakami ◽

Masataka Nakamura ◽

Yoshimi Nakamura ◽

Satoshi Kaneko ◽

Yusuke Yakushiji ◽

...

Keyword(s):

Case Report ◽

Motor Neuron ◽

Intermediate Filament ◽

Autopsy Case

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Spatial correlations between the neuronal inclusions, swollen achromatic neurons, and glial cells in neuronal intermediate filament inclusion disease (NIFID)

Journal of Neural Transmission ◽

10.1007/s00702-004-0205-0 ◽

2004 ◽

Vol 112 (4) ◽

pp. 473-480 ◽

Cited By ~ 2

Author(s):

N. J. Cairns ◽

R. A. Armstrong

Keyword(s):

Glial Cells ◽

Intermediate Filament ◽

Spatial Correlations ◽

Neuronal Inclusions

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Frontotemporal dementia with ubiquitinated neuronal inclusions presenting with primary lateral sclerosis and parkinsonism: clinicopathological report of an autopsy case

Acta Neuropathologica ◽

10.1007/s00401-003-0818-7 ◽

2004 ◽

Vol 107 (4) ◽

pp. 377-380 ◽

Cited By ~ 20

Author(s):

Akihide Mochizuki ◽

Yasuko Komatsuzaki ◽

Hiroyuki Iwamoto ◽

Shin?ichi Shoji

Keyword(s):

Frontotemporal Dementia ◽

Primary Lateral Sclerosis ◽

Autopsy Case ◽

Neuronal Inclusions ◽

Primary Lateral ◽

Lateral Sclerosis

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Paracrystalline Aggregates of Psoriatic Keratin and Their Relation to Normal Keratin Structure

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120096 ◽

1985 ◽

Vol 43 ◽

pp. 680-681

Author(s):

S. Trachtenberg ◽

P.M. Steinert ◽

B.L. Trus ◽

A.C. Steven

Keyword(s):

Cell Death ◽

Stratum Corneum ◽

Intermediate Filament ◽

Skin Disease ◽

Amorphous Matrix ◽

Terminal Differentiation ◽

Proteolytic Degradation ◽

Horny Layer ◽

Chronic Skin ◽

Chronic Skin Disease

During terminal differentiation of vertebrate epidermis, certain specific keratin intermediate filament (KIF) proteins are produced. Keratinization of the epidermis involves cell death and disruption of the cytoplasm, leaving a network of KIF embedded in an amorphous matrix which forms the outer horny layer known as the stratum corneum. Eventually these cells are shed (desquamation). Normally, the processes of differentiation, keratinization, and desquamation are regulated in an orderly manner. In psoriasis, a chronic skin disease, a hyperkeratotic stratum corneum is produced, resulting in abnormal desquamation of unusually large scales. In this disease, the normal KIF proteins are diminished in amount or absent, and other proteins more typical of proliferative epidermal cells are present. There is also evidence of proteolytic degradation of the KIF.

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An Early Developmental Marker for Radial Glia in Rat Spinal Cord

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100162648 ◽

1996 ◽

Vol 54 ◽

pp. 36-37

Author(s):

V. Kriho ◽

H.-Y. Yang ◽

C.-M. Lue ◽

N. Lieska ◽

G. D. Pappas

Keyword(s):

Spinal Cord ◽

Intermediate Filament ◽

Radial Glia ◽

Rat Spinal Cord ◽

Future Studies ◽

Spinal Cord Development ◽

Median Septum ◽

Differentiation Marker ◽

Early Developmental ◽

Developing Rat

Radial glia have been classically defined as those early glial cells that radially span their thin processes from the ventricular to the pial surfaces in the developing central nervous system. These radial glia constitute a transient cell population, disappearing, for the most part, by the end of the period of neuronal migration. Traditionally, it has been difficult to definitively identify these cells because the principal criteria available were morphologic only.Using immunofluorescence microscopy, we have previously defined a phenotype for radial glia in rat spinal cord based upon the sequential expression of vimentin, glial fibrillary acidic protein and an intermediate filament-associated protein, IFAP-70/280kD. We report here the application of another intermediate filament-associated protein, IFAP-300kD, originally identified in BHK-21 cells, to the immunofluorescence study of radial glia in the developing rat spinal cord.Results showed that IFAP-300kD appeared very early in rat spinal cord development. In fact by embryonic day 13, IFAP-300kD immunoreactivity was already at its peak and was observed in most of the radial glia which span the spinal cord from the ventricular to the subpial surfaces (Fig. 1). Interestingly, from this time, IFAP-300kD immunoreactivity diminished rapidly in a dorsal to ventral manner, so that by embryonic day 16 it was detectable only in the maturing macroglial cells in the marginal zone of the spinal cord and the dorsal median septum (Fig. 2). By birth, the spinal cord was essentially immuno-negative for this IFAP. Thus, IFAP-300kD appears to be another differentiation marker available for future studies of gliogenesis, especially for the early stages of radial glia differentiation.

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