A peculiar histopathological form of dysembryoplastic neuroepithelial tumor with separated pilocytic astrocytoma and rosette-forming glioneuronal tumor components

2014 ◽  
Vol 34 (5) ◽  
pp. 491-498 ◽  
Author(s):  
Ewa Matyja ◽  
Wiesława Grajkowska ◽  
Przemysław Kunert ◽  
Andrzej Marchel
Keyword(s):  
Pilocytic Astrocytoma ◽  
Glioneuronal Tumor ◽  
Dysembryoplastic Neuroepithelial Tumor

Complex Dysembryoplastic Neuroepithelial Tumor With Pilocytic Astrocytoma Component

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S44-S45
Author(s):  
Sandhyarani Dasaraju ◽  
Krutika Patel ◽  
Shalla Akbar ◽  
Osama Elkadi
Keyword(s):  
Contrast Enhancement ◽  
Pilocytic Astrocytoma ◽  
Early Recognition ◽  
Complex Form ◽  
Surgical Excision ◽  
Biological Behavior ◽  
Glioneuronal Tumor ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Who Grade ◽  
Complete Surgical Excision

Abstract Objectives Dysembryoplastic neuroepithelial tumor (DNET) is an uncommon mixed glioneuronal tumor. DNET is classified as WHO grade I neoplasm and commonly seen in the temporal lobe of children and young adults with features of pharmacoresistant seizures. The term complex DNET defines those tumors associated with additional features, including a pilocytic astrocytoma (PA) component, a finding that is rarely described in the literature. Methods Here we report a 16-year-old male who presented with seizures. On imaging, a 5.5 × 2.2 × 2.1-cm multiloculated mass was centered in the left frontoparietal gray matter with solid and cystic components and focal areas of contrast enhancement. Results Microscopic examination revealed a noninfiltrative glioneuronal neoplasm composed of a bland population of round to oval cells arranged around pools of mucinous material. Occasional large neuronal cells were noted. Focal areas composed of elongated astrocytic cells demonstrating piloid morphology were also present. No high-grade features were demonstrated. The findings are consistent with DNET, complex form in addition to a second component with piloid features resembling pilocytic astrocytoma. Conclusion The early recognition of DNET is important as it has an excellent prognosis on complete surgical excision without use of adjunct therapies. Unresected or incompletely removed DNET and secondary radiochemotherapy may give rise to recurrence and malignancy. The development of the secondary neoplasm challenges the stability in terms of biological behavior and highlights the importance of complete surgical excision and close follow-up. Our patient had neither undergone previous surgery nor received any adjuvant therapy, and hence this case is a de novo development of PA in a DNET. The association of contrast enhancement with DNET is an unusual finding in this case.

scholarly journals Clinical characteristics and surgical outcome of patients with temporal lobe tumors and epilepsy

2000 ◽  
Vol 58 (4) ◽  
pp. 1002-1008 ◽  
Author(s):  
CARMEN LISA JORGE ◽  
SUELY K. NAGAHASHI-MARIE ◽  
CHRISTIANE C. PEDREIRA ◽  
SÉRGIO ROSEMBERG ◽  
ROSA M.F. VALÉRIO ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Temporal Lobe ◽  
Pilocytic Astrocytoma ◽  
Clinical Characteristics ◽  
Pathological Diagnosis ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Precise Location ◽  
Histological Characteristics ◽  
Mri Characteristics

This is a retrospective study of 21 surgically treated patients with temporal lobe tumors and epilepsy. Evaluation included clinical data, EEG findings, structural scans, pathological diagnosis and post-surgical follow-up. There were 9 cases of ganglioglioma, 5 pilocytic astrocytoma, 3 ganglioneuroma, 2 dysembryoplastic neuroepithelial tumor, 1 pleomorphic xantoastrocytoma, and 1 meningioangiomatosis. Mean follow-up time was 22 months and outcome was evaluated according to Engel's classification; 76.2% were classified in class I and 23.8% in II and III. All patients classes II and III had been submitted to mesial and neocortical resections. There were no differences related to clinical characteristics, pathological diagnosis or duration of follow-up in patients seizure-free or not. All patients had abnormal MRI and ten of these had normal CT; the MRI characteristics were compared to pathological diagnosis and specific histological characteristics of the tumors were not discernible by MRI. We concluded that MRI was essential for the diagnosis and precise location of TL tumors. Ganglioglioma was the most frequent tumor and lesionectomy associated to mesial resection doesn't guarantee a better prognosis.

Rosette-forming glioneuronal tumors of the posterior fossa

2010 ◽  
Vol 5 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Manish N. Shah ◽  
Jeffrey R. Leonard ◽  
Arie Perry
Keyword(s):  
Posterior Fossa ◽  
Fourth Ventricle ◽  
Complete Resection ◽  
Glioneuronal Tumor ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Tumor Type ◽  
Who Grade ◽  
Pathological Characteristics ◽  
The Mean ◽  
Glioneuronal Tumors

Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare, recently described WHO Grade I neoplasm. The authors report 6 examples of RGNT arising primarily from the cerebellar vermis. All the patients were female, and the mean age of presentation was 24.8 years. The original diagnoses included pilocytic astrocytoma, ependymoma, cerebellar dysembryoplastic neuroepithelial tumor (DNT), and oligodendroglioma. The cases showed classic pathological characteristics, although in 2 cases the lesions included DNT-like “floating neurons” involving Purkinje cells, a feature which has not been previously reported to the authors' knowledge. The clinical outcome was excellent with no recurrences after complete resection. These cases expand the known clinical and histological spectrum of this rare tumor type. Given the lack of fourth ventricle involvement in most of these cases, the authors suggest revising the name to RGNT of the posterior fossa.

Development of a pilocytic astrocytoma in a dysembryoplastic neuroepithelial tumor

2007 ◽  
Vol 106 (6) ◽  
pp. 509-512 ◽  
Author(s):  
Vivek Josan ◽  
Paul Smith ◽  
Andrew Kornberg ◽  
Christian Rickert ◽  
Wirginia Maixner
Keyword(s):  
Pilocytic Astrocytoma ◽  
Dysembryoplastic Neuroepithelial Tumor

Mixed glioneuronal tumor: A dysembryoplastic neuroepithelial tumor with rosette‐forming glioneuronal tumor component

2012 ◽  
Vol 33 (4) ◽  
pp. 431-435 ◽  
Author(s):  
Ji Xiong ◽  
LiLi Ding ◽  
Hong Chen ◽  
Haixia Chen ◽  
Yin Wang
Keyword(s):  
Glioneuronal Tumor ◽  
Dysembryoplastic Neuroepithelial Tumor

scholarly journals Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Jesús Vaquero ◽  
Cristobal Saldaña ◽  
Santiago Coca ◽  
Mercedes Zurita
Keyword(s):  
Pilocytic Astrocytoma ◽  
Complex Form ◽  
Benign Neoplasm ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Cerebellar Tumor ◽  
Pathological Study ◽  
Contrast Administration ◽  
Light Enhancement ◽  
Gadolinium Administration ◽  
Form Variant

Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia. On CT-scan, an intraparenchymatous cerebellar tumor was disclosed. It was isodense, showing light enhancement after contrast administration. On MRI (T1-weighted image) the tumor was isointense, showing inhomogeneous hyperintensity after-gadolinium administration. On T2-weighted MRI, the tumor was inhomogenously hyperintense. At surgery, a solid and hypervascularized tumor was completely removed. Two years after surgery, the patient is symptom-free. Pathological study showed coexistence of areas of pilocytic astrocytoma with areas in which small rounded oligodendrocyte-like cells (OLC), with strong synaptophysin expression were identified. These neurocytic areas showed an eosinophilic matrix forming microcysts, and cells with aspect of “floating neurons” were occasionally identified. A complex form variant of DNT was diagnosed. Our case suggests that in presence of a cerebellar tumor with features of pilocytic astrocytoma, the possibility of a complex form variant of DNT should be considered.

scholarly journals A Rare Case of Dysembryoplastic Neuroepithelial Tumor

2012 ◽  
Vol 2 ◽  
pp. 60 ◽  
Author(s):  
Harsha Guduru ◽  
Jun K. Shen ◽  
Harish S. Lokannavar
Keyword(s):  
Rare Case ◽  
Intractable Epilepsy ◽  
Mass Effect ◽  
Glioneuronal Tumor ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Peritumoral Edema ◽  
Imaging Diagnosis ◽  
Common Presentation ◽  
The Central Nervous System ◽  
Children And Young Adults

We present a rare case of dysembryoplastic neuroepithelial tumor, a rare benign glioneuronal tumor of the central nervous system. It generally occurs in the supratentorial region and the temporal cerebral cortex in children and young adults. The most common presentation is epilepsy. The supratentorial tumor without any signs of mass effect or peritumoral edema is the conventionally accepted diagnostic criteria. In this case of a 19-year-old male with intractable epilepsy, atypical features such as the location of the tumor and the presence of mass effect and peritumoral edema made imaging diagnosis difficult. Diagnosis was confirmed through histopathology. Due to its recent discovery and relatively rare occurrence it is important for radiologists to recognize this disease entity.

Dysembryoplastic neuroepithelial tumor with rapid recurrence of pilocytic astrocytoma component

2013 ◽  
Vol 31 (2) ◽  
pp. 144-148 ◽  
Author(s):  
Yasuhide Takeuchi ◽  
Yoshiki Arakawa ◽  
Yoshiki Mikami ◽  
Riki Matsumoto ◽  
Susumu Miyamoto
Keyword(s):  
Pilocytic Astrocytoma ◽  
Dysembryoplastic Neuroepithelial Tumor
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