Anaplastic astrocytomas with abundant Rosenthal fibers in elderly patients: A diagnostic pitfall of high-grade gliomas

2013 ◽  
pp. n/a-n/a
Author(s):  
Yasuo Sugita ◽  
Shinji Nakashima ◽  
Koichi Ohshima ◽  
Mizuhiko Terasaki ◽  
Motohiro Morioka
Keyword(s):  
Elderly Patients ◽  
Rosenthal Fibers ◽  
High Grade ◽  
Diagnostic Pitfall ◽  
High Grade Gliomas

scholarly journals Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases

2018 ◽  
Vol 09 (03) ◽  
pp. 312-316 ◽  
Author(s):  
Meenu Gupta ◽  
Saurabh Bansal ◽  
Deep Shankar Pruthi ◽  
Manju Saini ◽  
Nadia Shirazi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Elderly Patients ◽  
Retrospective Analysis ◽  
Cox Regression ◽  
Rank Test ◽  
Karnofsky Performance Scale ◽  
High Grade ◽  
Concomitant Chemotherapy ◽  
Cox Regression Analysis ◽  
High Grade Gliomas

ABSTRACT Background and Objectives: Due to the aging of the population, diagnosis of high-grade gliomas (HGGs) in the elderly is becoming more common. The purpose of this study was to report our experience in 24 elderly patients with HGGs and evaluate the value of different prognostic factors. Design and Setting: Retrospective analysis of 24 elderly patients of ≥60 years with newly diagnosed HGGs, who were treated at our department between January 2009 and December 2012, was done. Patients and Methods: Age, gender, Karnofsky performance scale (KPS) score, extent of surgery, and use of temozolomide were evaluated using univariate and multivariate analyses. Survival was determined using the Kaplan–Meier method, and differences were compared using the log-rank test. Cox regression analysis was conducted to identify the independent prognostic factors. Results: The median overall survival of the patient cohort was 10 months. The 1- and 2-year survival rates were 45.8% and 16.6%, respectively. The analysis revealed that KPS score and use of concomitant chemotherapy were significant prognostic factors. Conclusion: The results of our analyses demonstrate that KPS score and use of concomitant chemotherapy yield encouraging outcomes in elderly patients with HGGs, validating the results published in research papers.

The treatment of elderly patients with high-grade gliomas

2003 ◽  
Vol 30 ◽  
pp. 58-62 ◽  
Author(s):  
Alba A Brandes ◽  
Silvio Monfardini
Keyword(s):  
Elderly Patients ◽  
High Grade ◽  
High Grade Gliomas

scholarly journals EPID-14OUTCOMES IN ELDERLY PATIENTS WITH HIGH GRADE GLIOMAS

2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v81.1-v81
Author(s):  
Lauren Gotterer ◽  
Nehaw Sarmey ◽  
Ming Chi ◽  
Zhijian Chen ◽  
Glen Stevens ◽  
...  
Keyword(s):  
Elderly Patients ◽  
High Grade ◽  
High Grade Gliomas

NCOG-09. PREDICTIVE GERIATRIC FACTORS IN ELDERLY PATIENTS TREATED FOR IDH-MUTANT HIGH-GRADE GLIOMAS: A FRENCH POLA NETWORK STUDY

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi153-vi153
Author(s):  
Coline Montégut ◽  
Jean-Sébastien Guillamo ◽  
François Ducray ◽  
Caroline Dehais ◽  
Cohen-Jonathan Moyal Elisabeth ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Elderly Patients ◽  
Body Mass ◽  
The Elderly ◽  
High Grade ◽  
Neuropsychological Disorders ◽  
Comorbidity Index ◽  
High Grade Gliomas ◽  
And Biological Markers

Abstract We aimed to describe the characteristics, patterns of care and predictive geriatric factors of elderly patients with IDH-mutant (IDHm) high-grade gliomas (HGG) included in the French POLA network, dedicated to HGG (including 68% of IDHm HGG). For IDHm HGG patients over the age of 70 years, geriatric features were collected: G8 score items (appetite, weight loss, mobility, neuropsychological disorders, body mass index, medications, self-rated health, age), Activities and Instrumental Activities of Daily Living (ADL, IADL) scores, Charlson’s comorbidity Index (CCI) and biological markers. Out of the 1433 HGG patients included in the POLA Network, 119 (8.3%) occurred in patients ≥ 70 years. Among them, 39 presented with IDHm HGG. Of these 39 patients, estimated G8 score was ≤ 14/17 for 16 patients (64%), ADL score was < 6 for 33.3%, IADL score was < 4 for 47% and CCI was ≥ 5 for 72%. Regarding treatment feasibility, 6 of the 19 patients treated by temozolomide prematurely discontinued chemotherapy including 2 for toxicity and 4 for progression. Five of the 10 patients treated by PCV prematurely discontinued chemotherapy, all for toxicity. In multivariate analysis, loss of mobility (p=0.018; p=0.008), severe neuropsychological disorders (p=0.005; p=0.047), body mass index < 21 kg/m2 (p=0.002; p=0.006) and ADL score < 6 (p=0.002; p=0.01) were significantly predictive of poor PFS and OS. Then we generated a specific brain geriatric score including these four items with a sensibility, specificity and AUC for long term survivor (≥ 48 months) of 100%, 83% and 0.948 respectively. Using a cutoff of < 10/13, this score was significantly correlated to PFS and OS (p< 0.001 both). In conclusion, geriatric predictive factors may contribute to the elderly management improvement: the brain geriatric score must now be validated in a prospective independent cohort including IDHm and IDHwt elderly patients.

scholarly journals P17.27 * HIGH GRADE GLIOMAS IN ELDERLY PATIENTS: RESULTS OF SURGERY AND INFLUENCE ON KARNOFSKY'S PERFORMANCE STATUS

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii93-ii93
Author(s):  
A. Agnoletti ◽  
R. Fornaro ◽  
F. M. C. Specchia ◽  
D. Garbossa ◽  
M. Lanotte ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Performance Status ◽  
High Grade ◽  
High Grade Gliomas ◽  
Results Of Surgery

Analysis of factors influencing the access to concomitant chemo-radiotherapy in elderly patients with high grade gliomas: role of MMSE, age and tumor volume

2017 ◽  
Vol 134 (2) ◽  
pp. 377-385 ◽  
Author(s):  
Andrea Di Cristofori ◽  
Barbara Zarino ◽  
Claudia Fanizzi ◽  
Giorgia Abete Fornara ◽  
Giulio Bertani ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Tumor Volume ◽  
High Grade ◽  
Factors Influencing ◽  
High Grade Gliomas

Neutrophil/Lymphocyte Ratio Is an Independent Prognostic Factor in Elderly Patients with High-Grade Gliomas

2019 ◽  
Vol 127 ◽  
pp. e261-e267 ◽  
Author(s):  
Youjun Gan ◽  
Xingwang Zhou ◽  
Xiaodong Niu ◽  
Jiaoming Li ◽  
Tianwei Wang ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Elderly Patients ◽  
Independent Prognostic Factor ◽  
High Grade ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
High Grade Gliomas

Venous Thromboembolism and High Grade Gliomas

1993 ◽  
Vol 70 (03) ◽  
pp. 393-396 ◽  
Author(s):  
Mandeep S Dhami ◽  
Robert D Bona ◽  
John A Calogero ◽  
Richard M Hellman
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Medical Center ◽  
Significant Risk ◽  
Bleeding Complications ◽  
Fisher Exact Test ◽  
High Grade ◽  
Chi Square ◽  
Exact Test ◽  
High Grade Gliomas

SummaryA retrospective study was done to determine the incidence of and the risk factors predisposing to clinical venous thromboembolism (VTE) in patients treated for high grade gliomas. Medical records of 68 consecutive patients diagnosed and treated at Saint Francis Hospital and Medical Center from January 1986 to June 1991 were reviewed. The follow up was to time of death or at least 6 months (up to December 1991). All clinically suspected episodes of VTE were confirmed by objective tests. Sixteen episodes of VTE were detected in 13 patients for an overall episode rate of 23.5%. Administration of chemotherapy (p = 0.027, two tailed Fisher exact test) and presence of paresis (p = 0.031, two tailed Fisher exact test) were statistically significant risk factors for the development of VTE. Thrombotic events were more likely to occur in the paretic limb and this difference was statistically significant (p = 0.00049, chi square test, with Yates correction). No major bleeding complications were seen in the nine episodes treated with long term anticoagulation.We conclude that venous thromboembolic complications are frequently encountered in patients being treated for high grade gliomas and the presence of paresis and the administration of chemotherapy increases the risk of such complications.

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