Low Intensity Focused Ultrasound Increases Duration of Anti‐Nociceptive Responses in Female Common Peroneal Nerve Injury Rats

2021 ◽  
Author(s):  
Andrea Liss ◽  
Abigail Hellman ◽  
Vraj J. Patel ◽  
Teresa Maietta ◽  
Kanakaharini Byraju ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Peroneal Nerve ◽  
Focused Ultrasound ◽  
Common Peroneal Nerve ◽  
Low Intensity ◽  
Nociceptive Responses ◽  
Peroneal Nerve Injury

Effects of external low intensity focused ultrasound on electrophysiological changes in vivo in a rodent model of common peroneal nerve injury

Neuroscience ◽  
2020 ◽  
Vol 429 ◽  
pp. 264-272 ◽  
Author(s):  
Abigail Hellman ◽  
Teresa Maietta ◽  
Kanakaharini Byraju ◽  
Yunseo Linda Park ◽  
Andrea Liss ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Peroneal Nerve ◽  
Focused Ultrasound ◽  
Common Peroneal Nerve ◽  
Rodent Model ◽  
Low Intensity ◽  
Peroneal Nerve Injury

External focused ultrasound treatment for neuropathic pain induced by common peroneal nerve injury

2018 ◽  
Vol 684 ◽  
pp. 145-151 ◽  
Author(s):  
Tarun Prabhala ◽  
Abigail Hellman ◽  
Ian Walling ◽  
Teresa Maietta ◽  
Jiang Qian ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Peroneal Nerve ◽  
Focused Ultrasound ◽  
Common Peroneal Nerve ◽  
Ultrasound Treatment ◽  
Peroneal Nerve Injury

scholarly journals Effects of External Focused Ultrasound on Inflammatory Markers in Neuropathic Pain Caused by Common Peroneal Nerve Injury

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Adithya Srikanthan ◽  
Teresa Maietta ◽  
Abigail Hellman ◽  
Vraj Patel ◽  
Alicia Clum ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Pain Relief ◽  
Nerve Injury ◽  
Inflammatory Cytokines ◽  
Peroneal Nerve ◽  
Focused Ultrasound ◽  
Common Peroneal Nerve ◽  
Female Rats ◽  
Male Rats ◽  
Peroneal Nerve Injury

Abstract INTRODUCTION Various rodent models have long been employed to study treatments for chronic pain. However, these studies have resulted in unsuccessful phase-I and II human trials that have failed to result in viable options for patients. Though limitations of animal models are no doubt one issue, lack of objective markers corresponding with pain relief play a role. Our lab has shown significant pain relief in a common peroneal nerve injury (CPNI) rat model following administration of external pulsed low-intensity focused ultrasound (liFUS), thus, establishing external liFUS as a promising technique for treatment of neuropathic pain. Current knowledge of liFUS effects are limited to observable behavioral changes, and little is known of the mechanism of action. To successfully translate this device into the clinic, we examine molecular changes in the inflammatory cascade. METHODS Male rats underwent CPNI to induce neuropathic pain. External liFUS treatment was performed on the L5 dorsal root ganglion (DRG) in the neuropathic model, which was determined from responses to Von Frey fibers (VFF). 24 h post liFUS treatment, L5 DRGs were obtained from 4 distinct cohorts: rats that underwent CPNI with liFUS, CPNI with sham liFUS, sham CPNI with liFUS, and sham CPNI sham liFUS (n = 4 for each group). Using a membrane-based sandwich immunoassay (Proteome Profiler Rat Cytokine Array Kit from R&D System), we assessed relative abundances of 6 anti-inflammatory cytokines and 16 pro-inflammatory cytokines. RESULTS CPNI resulted in an 82.5% decrease of tumor necrosis factor alpha (TNFa) and a 61.8% increase of macrophage inflammatory protein 1-alpha (MIP-1a). liFUS led to a 60% decrease in MIP-1a and a 40% increase in TNFa. Other changes in cytokines were not affected by CPNI or liFUS. CONCLUSION liFUS resulted in similar changes in TNFa and MIP-1a, as compared to spinal cord stimulation and other medical treatments for pain syndromes. Further work will examine inflammatory responses over time and in female rats.

Isokinetic cross-training effect in foot drop following common peroneal nerve injury

2015 ◽  
Vol 23 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Andrea Manca ◽  
Francesco Pisanu ◽  
Enzo Ortu ◽  
Edoardo De Natale ◽  
Francesca Ginatempo ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Peroneal Nerve ◽  
Common Peroneal Nerve ◽  
Foot Drop ◽  
Training Effect ◽  
Cross Training ◽  
Peroneal Nerve Injury

Iatrogenic common peroneal nerve injury during harvesting of semitendinosus tendon for anterior cruciate ligament reconstruction

2021 ◽  
Vol 14 (4) ◽  
pp. e240736
Author(s):  
Raf Mens ◽  
Albert van Houten ◽  
Roy Bernardus Gerardus Brokelman ◽  
Roy Hoogeslag
Keyword(s):  
Anterior Cruciate Ligament ◽  
Nerve Injury ◽  
Peroneal Nerve ◽  
Cruciate Ligament ◽  
Common Peroneal Nerve ◽  
Peroneal Nerve Injury ◽  
The Common ◽  
Anterior Cruciate ◽  
Incision Technique

We present a case of iatrogenic injury to the common peroneal nerve (CPN) occurring due to harvesting of a hamstring graft, using a posterior mini-incision technique. A twitch of the foot was noted on retraction of the tendon stripper. After clinically diagnosing a CPN palsy proximal to the knee, the patient was referred to a neurosurgeon within 24 hours. An electromyography (EMG) was not obtained since it cannot accurately differentiate between partial and complete nerve injury in the first week after injury. Because the nerve might have been transacted by the tendon stripper, surgical exploration within 72 hours after injury was indicated. An intraneural haematoma was found and neurolysis was performed to decompress the nerve. Functioning of the anterior cruciate ligament was satisfactory during follow-up. Complete return of motor function of the CPN was observed at 1-year follow-up, with some remaining hypoaesthesia.

Translocation of the soleus muscular branch of the tibial nerve to repair high common peroneal nerve injury

2019 ◽  
Vol 161 (2) ◽  
pp. 271-277 ◽  
Author(s):  
Huihao Chen ◽  
Depeng Meng ◽  
Gang Yin ◽  
Chunlin Hou ◽  
Haodong Lin
Keyword(s):  
Nerve Injury ◽  
Peroneal Nerve ◽  
Tibial Nerve ◽  
Common Peroneal Nerve ◽  
Peroneal Nerve Injury ◽  
Muscular Branch
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