Identification of Deep Brain Stimulation Targets for Neuropathic Pain After Spinal Cord Injury Using Localized Increases in White Matter Fiber Cross‐Section

2021 ◽  
Author(s):  
Shana R. Black ◽  
Andrew Janson ◽  
Mark Mahan ◽  
Jeffrey Anderson ◽  
Christopher R. Butson
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Deep Brain Stimulation ◽  
White Matter ◽  
Cross Section ◽  
Brain Stimulation ◽  
Fiber Cross Section ◽  
Cord Injury ◽  
Deep Brain

Deep Brain Stimulation Improves Motor Function in Rats with Spinal Cord Injury by Increasing Synaptic Plasticity

2020 ◽  
Vol 140 ◽  
pp. e294-e303
Author(s):  
Min Wang ◽  
Lina Jia ◽  
Xiaobo Wu ◽  
Zuoli Sun ◽  
Zheng Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Synaptic Plasticity ◽  
Deep Brain Stimulation ◽  
Motor Function ◽  
Brain Stimulation ◽  
Cord Injury ◽  
Deep Brain

scholarly journals Deep brain stimulation for locomotion in incomplete human spinal cord injury (DBS-SCI): protocol of a prospective one-armed multi-centre study

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e047670
Author(s):  
Lennart H Stieglitz ◽  
Anna-Sophie Hofer ◽  
Marc Bolliger ◽  
Markus F Oertel ◽  
Linard Filli ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Deep Brain Stimulation ◽  
Functional Recovery ◽  
Brain Stimulation ◽  
Multi Centre Study ◽  
Intensive Training ◽  
Centre Study ◽  
Cord Injury ◽  
Deep Brain

IntroductionSpinal cord injury (SCI) is a devastating condition with immediate impact on the individual’s health and quality of life. Major functional recovery reaches a plateau 3–4 months after injury despite intensive rehabilitative training. To enhance training efficacy and improve long-term outcomes, the combination of rehabilitation with electrical modulation of the spinal cord and brain has recently aroused scientific interest with encouraging results. The mesencephalic locomotor region (MLR), an evolutionarily conserved brainstem locomotor command and control centre, is considered a promising target for deep brain stimulation (DBS) in patients with SCI. Experiments showed that MLR-DBS can induce locomotion in rats with spinal white matter destructions of >85%.Methods and analysisIn this prospective one-armed multi-centre study, we investigate the safety, feasibility, and therapeutic efficacy of MLR-DBS to enable and enhance locomotor training in severely affected, subchronic and chronic American Spinal Injury Association Impairment Scale C patients in order to improve functional recovery. Patients undergo an intensive training programme with MLR-DBS while being regularly followed up until 6 months post-implantation. The acquired data of each timepoint are compared with baseline while the primary endpoint is performance in the 6-minute walking test. The clinical trial protocol was written in accordance with the Standard Protocol Items: Recommendations for Interventional Trials checklist.Ethics and disseminationThis first in-man study investigates the therapeutic potential of MLR-DBS in SCI patients. One patient has already been implanted with electrodes and underwent MLR stimulation during locomotion. Based on the preliminary results which promise safety and feasibility, recruitment of further patients is currently ongoing. Ethical approval has been obtained from the Ethical Committee of the Canton of Zurich (case number BASEC 2016-01104) and Swissmedic (10000316). Results will be published in peer-reviewed journals and presented at conferences.Trial registration numberNCT03053791.

Deep Brain Stimulation of the Midbrain Locomotor Region Improves Paretic Hindlimb Function After Spinal Cord Injury in Rats

2013 ◽  
Vol 5 (208) ◽  
pp. 208ra146-208ra146 ◽  
Author(s):  
L. C. Bachmann ◽  
A. Matis ◽  
N. T. Lindau ◽  
P. Felder ◽  
M. Gullo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Cord Injury ◽  
Deep Brain ◽  
Stimulation Of
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