Electric Field Strength From Prefrontal Transcranial Direct Current Stimulation Determines Degree of Working Memory Response: A Potential Application of Reverse‐Calculation Modeling?

2020 ◽  
Author(s):  
Kevin A. Caulfield ◽  
Aprinda Indahlastari ◽  
Nicole R. Nissim ◽  
James W. Lopez ◽  
Holly H. Fleischmann ◽  
...  
Keyword(s):  
Working Memory ◽  
Field Strength ◽  
Electric Field ◽  
Electric Field Strength ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Potential Application ◽  
Memory Response ◽  
Direct Current Stimulation

scholarly journals Deep Cerebellar Transcranial Direct Current Stimulation of the Dentate Nucleus to Facilitate Standing Balance in Chronic Stroke Survivors

2019 ◽  
Author(s):  
Zeynab Rezaee ◽  
Surbhi Kaura ◽  
Dhaval Solanki ◽  
Adyasha Dash ◽  
M V Padma Srivastava ◽  
...  
Keyword(s):  
Field Strength ◽  
Electric Field ◽  
Electric Field Strength ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Lower Limb ◽  
Standing Balance ◽  
Stroke Survivors ◽  
Post Stroke ◽  
Functional Reach

Objective: Cerebrovascular accidents are the second leading cause of death and the third leading cause of disability worldwide. We hypothesized that cerebellar transcranial direct current stimulation (ctDCS) of the dentate nuclei and the lower-limb representations in the cerebellum can improve standing balance functional reach in chronic (> 6 months’ post-stroke) stroke survivors. Materials and Methods: Magnetic resonance imaging(MRI) based subject-specific electric field was computed across 10 stroke survivors and one healthy MRI template to find an optimal bipolar bilateral ctDCS montage to target dentate nuclei and lower-limb representations (lobules VII-IX). Then, in a repeated-measure crossover study on 5 stroke survivors, we compared 15minutes of 2mA ctDCS based on the effects on successful functional reach(%) during standing balance task. Three-way ANOVA investigated the factors of interest– brain regions, montages, stroke participants, and their interactions.Results: “One-size-fits-all” ctDCS montage for the clinical study was found to be bipolar PO9h – PO10h for dentate nuclei and bipolar Exx7–Exx8 for lobules VII-IX with contalesional anode. Bipolar PO9h–PO10h ctDCS performed significantly (alpha=0.05) better in facilitating successful functional reach (%) when compared to bipolar Exx7–Exx8 ctDCS. Furthermore, a linear relationship between successful functional reach (%) and electric field strength was found where bipolar PO9h–PO10h montage resulted in a significantly (alpha=0.05) higher electric field strength when compared to bipolar Exx7–Exx8 montage for the same 2mA current. Conclusion: We presented a rational neuroimaging based approach to optimize deep ctDCS of the dentate nuclei and lower limb representations in the cerebellum for post-stroke balance rehabilitation.

scholarly journals Deep Cerebellar Transcranial Direct Current Stimulation of the Dentate Nucleus to Facilitate Standing Balance in Chronic Stroke Survivors—A Pilot Study

2020 ◽  
Vol 10 (2) ◽  
pp. 94 ◽  
Author(s):  
Zeynab Rezaee ◽  
Surbhi Kaura ◽  
Dhaval Solanki ◽  
Adyasha Dash ◽  
M V Padma Srivastava ◽  
...  
Keyword(s):  
Pilot Study ◽  
Field Strength ◽  
Electric Field ◽  
Electric Field Strength ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Lower Limb ◽  
Standing Balance ◽  
Stroke Survivors ◽  
Functional Reach

Objective: Cerebrovascular accidents are the second leading cause of death and the third leading cause of disability worldwide. We hypothesized that cerebellar transcranial direct current stimulation (ctDCS) of the dentate nuclei and the lower-limb representations in the cerebellum can improve functional reach during standing balance in chronic (>6 months’ post-stroke) stroke survivors. Materials and Methods: Magnetic resonance imaging (MRI) based subject-specific electric field was computed across a convenience sample of 10 male chronic (>6 months) stroke survivors and one healthy MRI template to find an optimal bipolar bilateral ctDCS montage to target dentate nuclei and lower-limb representations (lobules VII–IX). Then, in a repeated-measure crossover study on a subset of 5 stroke survivors, we compared 15 min of 2 mA ctDCS based on the effects on successful functional reach (%) during standing balance task. Three-way ANOVA investigated the factors of interest– brain regions, montages, stroke participants, and their interactions. Results: “One-size-fits-all” bipolar ctDCS montage for the clinical study was found to be PO9h–PO10h for dentate nuclei and Exx7–Exx8 for lobules VII–IX with the contralesional anode. PO9h–PO10h ctDCS performed significantly (alpha = 0.05) better in facilitating successful functional reach (%) when compared to Exx7–Exx8 ctDCS. Furthermore, a linear relationship between successful functional reach (%) and electric field strength was found where PO9h–PO10h montage resulted in a significantly (alpha = 0.05) higher electric field strength when compared to Exx7–Exx8 montage for the same 2 mA current. Conclusion: We presented a rational neuroimaging based approach to optimize deep ctDCS of the dentate nuclei and lower limb representations in the cerebellum for post-stroke balance rehabilitation. However, this promising pilot study was limited by “one-size-fits-all” bipolar ctDCS montage as well as a small sample size.

scholarly journals Effects of transcranial direct current stimulation combined with listening to preferred music on memory in older adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ricky Chow ◽  
Alix Noly-Gandon ◽  
Aline Moussard ◽  
Jennifer D. Ryan ◽  
Claude Alain
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Recognition Memory ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Digit Span ◽  
Recognition Task ◽  
Music Listening ◽  
Subsequent Performance ◽  
Direct Current Stimulation

AbstractListening to autobiographically-salient music (i.e., music evoking personal memories from the past), and transcranial direct current stimulation (tDCS) have each been suggested to temporarily improve older adults’ subsequent performance on memory tasks. Limited research has investigated the effects of combining both tDCS and music listening together on cognition. The present study examined whether anodal tDCS stimulation over the left dorsolateral prefrontal cortex (2 mA, 20 min) with concurrent listening to autobiographically-salient music amplified subsequent changes in working memory and recognition memory in older adults than either tDCS or music listening alone. In a randomized sham-controlled crossover study, 14 healthy older adults (64–81 years) participated in three neurostimulation conditions: tDCS with music listening (tDCS + Music), tDCS in silence (tDCS-only), or sham-tDCS with music listening (Sham + Music), each separated by at least a week. Working memory was assessed pre- and post-stimulation using a digit span task, and recognition memory was assessed post-stimulation using an auditory word recognition task (WRT) during which electroencephalography (EEG) was recorded. Performance on the backwards digit span showed improvement in tDCS + Music, but not in tDCS-only or Sham + Music conditions. Although no differences in behavioural performance were observed in the auditory WRT, changes in neural correlates underlying recognition memory were observed following tDCS + Music compared to Sham + Music. Findings suggest listening to autobiographically-salient music may amplify the effects of tDCS for working memory, and highlight the potential utility of neurostimulation combined with personalized music to improve cognitive performance in the aging population.

scholarly journals Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Edward T. Dougherty ◽  
James C. Turner ◽  
Frank Vogel
Keyword(s):  
Electric Field ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Three Dimensional ◽  
Human Head ◽  
Multiscale Model ◽  
Medical Intervention ◽  
Medical Community ◽  
Computational Grids ◽  
Direct Current Stimulation

Transcranial direct current stimulation (tDCS) continues to demonstrate success as a medical intervention for neurodegenerative diseases, psychological conditions, and traumatic brain injury recovery. One aspect of tDCS still not fully comprehended is the influence of the tDCS electric field on neural functionality. To address this issue, we present a mathematical, multiscale model that couples tDCS administration to neuron electrodynamics. We demonstrate the model’s validity and medical applicability with computational simulations using an idealized two-dimensional domain and then an MRI-derived, three-dimensional human head geometry possessing inhomogeneous and anisotropic tissue conductivities. We exemplify the capabilities of these simulations with real-world tDCS electrode configurations and treatment parameters and compare the model’s predictions to those attained from medical research studies. The model is implemented using efficient numerical strategies and solution techniques to allow the use of fine computational grids needed by the medical community.

scholarly journals Effects of Transcranial Direct Current Stimulation on effort during a working-memory task

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
David Framorando ◽  
Tianlan Cai ◽  
Yi Wang ◽  
Alan J. Pegna
Keyword(s):  
Working Memory ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Memory Task ◽  
Time Interval ◽  
Direct Current Stimulation ◽  
Anodal Stimulation ◽  
Dorsolateral Prefrontal ◽  
Systolic Time ◽  
Task Mastery

AbstractTranscranial Direct Current Stimulation (tDCS) has shown that stimulation of Dorsolateral Prefrontal Cortex (DLPFC) facilitates task performance in working-memory tasks. However, little is known about its potential effects on effort. This study examined whether tDCS affects effort during a working-memory task. Participants received anodal, cathodal and sham stimulation over DLPFC across three sessions before carrying out a 2-back task. During the task, effort-related cardiovascular measures were recorded—especially the Initial Systolic Time Interval (ISTI). Results showed that anodal stimulation produced a shorter ISTI, indicating a greater effort compared to cathodal and sham conditions, where effort was lower. These findings demonstrate that anodal stimulation helps participants to maintain engagement in a highly demanding task (by increasing task mastery), without which they would otherwise disengage. This study is the first to show that tDCS impacts the extent of effort engaged by individuals during a difficult task.

Determinants of the electric field during transcranial direct current stimulation

NeuroImage ◽  
2015 ◽  
Vol 109 ◽  
pp. 140-150 ◽  
Author(s):  
Alexander Opitz ◽  
Walter Paulus ◽  
Susanne Will ◽  
Andre Antunes ◽  
Axel Thielscher
Keyword(s):  
Electric Field ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation

High-Definition Transcranial Direct Current Stimulation Improves Delayed Memory in Alzheimer’s Disease Patients: A Pilot Study Using Computational Modeling to Optimize Electrode Position

2021 ◽  
pp. 1-17
Author(s):  
Ingrid Daae Rasmussen ◽  
Nya Mehnwolo Boayue ◽  
Matthias Mittner ◽  
Martin Bystad ◽  
Ole K. Grnli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Electric Field ◽  
Computational Modeling ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cortical Atrophy ◽  
Brain Anatomy ◽  
High Definition ◽  
Direct Current Stimulation

Background: The optimal stimulation parameters when using transcranial direct current stimulation (tDCS) to improve memory performance in patients with Alzheimer’s disease (AD) are lacking. In healthy individuals, inter-individual differences in brain anatomy significantly influence current distribution during tDCS, an effect that might be aggravated by variations in cortical atrophy in AD patients. Objective: To measure the effect of individualized HD-tDCS in AD patients. Methods: Nineteen AD patients were randomly assigned to receive active or sham high-definition tDCS (HD-tDCS). Computational modeling of the HD-tDCS-induced electric field in each patient’s brain was analyzed based on magnetic resonance imaging (MRI) scans. The chosen montage provided the highest net anodal electric field in the left dorsolateral prefrontal cortex (DLPFC). An accelerated HD-tDCS design was conducted (2 mA for 3×20 min) on two separate days. Pre- and post-intervention cognitive tests and T1 and T2-weighted MRI and diffusion tensor imaging data at baseline were analyzed. Results: Different montages were optimal for individual patients. The active HD-tDCS group improved significantly in delayed memory and MMSE performance compared to the sham group. Five participants in the active group had higher scores on delayed memory post HD-tDCS, four remained stable and one declined. The active HD-tDCS group had a significant positive correlation between fractional anisotropy in the anterior thalamic radiation and delayed memory score. Conclusion: HD-tDCS significantly improved delayed memory in AD. Our study can be regarded as a proof-of-concept attempt to increase tDCS efficacy. The present findings should be confirmed in larger samples.

Sign in / Sign up

Export Citation Format

Share Document