Transcutaneous Vagus Nerve Stimulation in Patients With Severe Traumatic Brain Injury: A Feasibility Trial

2020 ◽  
Vol 23 (6) ◽  
pp. 859-864 ◽  
Author(s):  
Jakob Hakon ◽  
Melika Moghiseh ◽  
Ingrid Poulsen ◽  
Christoffer M.L. Øland ◽  
Christian P. Hansen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vagus Nerve ◽  
Severe Traumatic Brain Injury ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Feasibility Trial ◽  
Transcutaneous Vagus Nerve Stimulation

scholarly journals Neuroprotective effects of vagus nerve stimulation on traumatic brain injury

2014 ◽  
Vol 9 (17) ◽  
pp. 1585 ◽  
Author(s):  
Yigang Yu ◽  
Long Zhou ◽  
Jinhuang Lin ◽  
Junming Lin ◽  
Guoju Kui ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Neuroprotective Effects

Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury

2015 ◽  
Vol 24 (2) ◽  
pp. 308-319 ◽  
Author(s):  
Daniel Neren ◽  
Matthew D. Johnson ◽  
Wynn Legon ◽  
Salam P. Bachour ◽  
Geoffrey Ling ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation

Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB/NLRP3 Signaling Pathway

2020 ◽  
Vol 34 (9) ◽  
pp. 831-843
Author(s):  
Yunliang Tang ◽  
Xiaoyang Dong ◽  
Gengfa Chen ◽  
Wen Ye ◽  
Junwei Kang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vagus Nerve ◽  
Signaling Pathway ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Critical Role ◽  
Neurological Deficits ◽  
Receptor Protein

Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Oxidative stress, inflammation, and apoptosis are vital pathophysiological features post-TBI. Objectives Research has shown that vagus nerve stimulation (VNS) can attenuate oxidative stress in various diseases. However, the critical role of VNS in TBI is still not completely understood. This study investigated the protective effects and potential mechanism of VNS on TBI. Methods Male Sprague-Dawley rats were randomized into 3 groups: sham, TBI, and TBI + VNS. The TBI model was induced in rats by the free-fall drop method. The vagal nerve trunk was separated, and VNS was performed after establishing the TBI model. Results The results showed that VNS significantly ameliorated tissue damage, neurological deficits, and cerebral edema, compared with the sham VNS group. Additionally, VNS alleviated oxidative stress, inflammation, and apoptosis in the pericontusive cortex of rats after TBI. VNS also significantly suppressed expression of the nuclear factor-κB (NF-κB) protein in the nucleus and activation of the nucleotide-binding domain–like receptor protein 3 (NLRP3) inflammasome. Conclusions Taken together, the present study indicates that VNS may attenuate brain damage after TBI by inhibiting oxidative stress, inflammation, and apoptosis, possibly through the NF-κB/NLRP3 signaling pathway.

scholarly journals Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

2016 ◽  
Vol 33 (9) ◽  
pp. 871-879 ◽  
Author(s):  
David T. Pruitt ◽  
Ariel N. Schmid ◽  
Lily J. Kim ◽  
Caroline M. Abe ◽  
Jenny L. Trieu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Recovery Of Function ◽  
Motor Training

Non-invasive vagus nerve stimulation for the prevention/treatment of comorbid mild traumatic brain injury and PTSD

2019 ◽  
Vol 12 (2) ◽  
pp. 418-419
Author(s):  
A. Schindler ◽  
J. Meabon ◽  
B. Baskin ◽  
E. Cooper ◽  
M. Yagi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vagus Nerve ◽  
Mild Traumatic Brain Injury ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Non Invasive

scholarly journals Vagus nerve stimulation may protect GABAergic neurons following traumatic brain injury in rats: An immunocytochemical study

2007 ◽  
Vol 1128 ◽  
pp. 157-163 ◽  
Author(s):  
Steven L. Neese ◽  
Luke K. Sherill ◽  
Arlene A. Tan ◽  
Rodney W. Roosevelt ◽  
Ronald A. Browning ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Gabaergic Neurons ◽  
Immunocytochemical Study
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