scholarly journals Changes in Neuronal Activity in the Anterior Cingulate Cortex and Primary Somatosensory Cortex With Nonlinear Burst and Tonic Spinal Cord Stimulation

2020 ◽  
Vol 23 (5) ◽  
pp. 594-604 ◽  
Author(s):  
Julia C. Quindlen‐Hotek ◽  
Alexander R. Kent ◽  
Patrisia De Anda ◽  
Sonia Kartha ◽  
Alexander M. Benison ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Anterior Cingulate Cortex ◽  
Somatosensory Cortex ◽  
Neuronal Activity ◽  
Spinal Cord Stimulation ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Primary Somatosensory Cortex

scholarly journals Cortical Pain Processing in the Rat Anterior Cingulate Cortex and Primary Somatosensory Cortex

2019 ◽  
Vol 13 ◽  
Author(s):  
Zhengdong Xiao ◽  
Erik Martinez ◽  
Prathamesh M. Kulkarni ◽  
Qiaosheng Zhang ◽  
Qianning Hou ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Somatosensory Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Primary Somatosensory Cortex ◽  
Pain Processing

Human Anterior Cingulate Cortex Neurons Modulated by Attention-Demanding Tasks

2000 ◽  
Vol 83 (6) ◽  
pp. 3575-3577 ◽  
Author(s):  
Karen D. Davis ◽  
William D. Hutchison ◽  
Andres M. Lozano ◽  
Ronald R. Tasker ◽  
Jonathan O. Dostrovsky
Keyword(s):  
Anterior Cingulate Cortex ◽  
Neuronal Activity ◽  
Cognitive Functions ◽  
Single Neuron ◽  
Direct Evidence ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Cognitive State ◽  
Imaging Studies ◽  
Spontaneous Neuronal Activity

Recent imaging studies have implicated the anterior cingulate cortex (ACC) in various cognitive functions, including attention. However, until now, there was no evidence for changes in neuronal activity of individual ACC neurons during performance of tasks that require attention and effortful thought. We hypothesized these neurons must exist in the human ACC. In this study, we present electrophysiological data from microelectrode single neuron recordings in the human ACC of neuronal modulation during attention-demanding tasks in 19% of 36 neurons tested. These findings provide the first direct evidence of an influence of a cognitive state on the spontaneous neuronal activity of human ACC neurons.

scholarly journals Interplay of spinal and vagal pathways on esophageal acid-related anterior cingulate cortex functional networks in rats

2019 ◽  
Vol 316 (5) ◽  
pp. G615-G622
Author(s):  
Patrick Sanvanson ◽  
Zhixin Li ◽  
Ling Mei ◽  
Venelin Kounev ◽  
Mark Kern ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Somatosensory Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Acid Infusion ◽  
Spinal Nerves ◽  
Secondary Somatosensory Cortex ◽  
Before And After ◽  
Bilateral Vagotomy

Esophageal acid sensory signals are transmitted by both vagal and spinal pathways to the cerebral cortex. The influence and interplay of these pathways on esophageal acid-related functional connectivity has been elusive. Our aim was to evaluate the esophageal acid exposure-related effect on the anterior cingulate cortex (ACC) functional connectivity networks using functional MRI-guided functional connectivity MRI (fcMRI) analysis. We studied six Sprague-Dawley rats for fcMRI experiments under dexmedetomidine hydrochloride anesthesia. Each rat was scanned for 6 min before and after esophageal hydrochloric acid infusion (0.1 N, 0.2 ml/min). The protocol was repeated before and after bilateral cervical vagotomy on the same rat. Seed-based fcMRI analysis was used to examine ACC networks and acid-induced network alterations. Three-factor repeated-measures ANOVA analysis among all four subgroups revealed that the interaction of acid infusion and bilateral vagotomy was mainly detected in the hypothalamus, insula, left secondary somatosensory cortex, left parietal cortex, and right thalamus in the left ACC network. In the right ACC network, this interaction effect was detected in the caudate putamen, insula, motor, primary somatosensory cortex, secondary somatosensory cortex, and thalamic regions. These regions in the ACC networks showed decreased intranetwork connectivity due to acid infusion. However, after bilateral vagotomy, intranetwork connectivity strength inversed and became stronger following postvagotomy acid infusion. Signals transmitted through both the vagal nerve and spinal nerves play a role in esophageal acid-related functional connectivity of the ACC. The vagal signals appear to dampen the acid sensation-related functional connectivity of the ACC networks. NEW & NOTEWORTHY These studies show that esophageal acid-induced brain functional connectivity changes are vagally mediated and suggest that signals transmitted through both the vagal nerve and spinal nerves play a role in esophageal acid-related functional connectivity of the anterior cingulate cortex. This paper focuses on the development of a novel rat functional MRI model fostering improved understanding of acid-related esophageal disorders.

Sign in / Sign up

Export Citation Format

Share Document