Optical Modulation on the Nucleus Accumbens Core in the Alleviation of Neuropathic Pain in Chronic Dorsal Root Ganglion Compression Rat Model

2019 ◽  
Vol 23 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Elina KC ◽  
Hyeong Cheol Moon ◽  
Soochong Kim ◽  
Hyong Kyu Kim ◽  
So Yoon Won ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Dorsal Root Ganglion ◽  
Rat Model ◽  
Dorsal Root ◽  
Optical Modulation ◽  
Nucleus Accumbens Core ◽  
Accumbens Core

Altered tachykinin expression by dorsal root ganglion neurons in a rat model of neuropathic pain

Pain ◽  
1994 ◽  
Vol 58 (2) ◽  
pp. 219-231 ◽  
Author(s):  
James E. Marchand ◽  
Heinrich W. Wurm ◽  
Toshimasa Kato ◽  
Richard M. Kream
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Rat Model ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Ganglion Neurons

scholarly journals Role of nucleus accumbens core in alleviation of neuropathic pain induced by chronic compression of DRG

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S347
Author(s):  
Elina Kc ◽  
Hyeong Cheol Moon ◽  
Sang Hwan Hyun ◽  
Young Seok Park
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Nucleus Accumbens Core ◽  
Accumbens Core

Increased expression of cannabinoid receptor 1 in the nucleus accumbens core in a rat model with morphine withdrawal

2013 ◽  
Vol 1531 ◽  
pp. 102-112 ◽  
Author(s):  
Wei-Xin Yuan ◽  
Li-Jun Heng ◽  
Jie Ma ◽  
Xing-Qin Wang ◽  
Li-Juan Qu ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Rat Model ◽  
Cannabinoid Receptor ◽  
Morphine Withdrawal ◽  
Cannabinoid Receptor 1 ◽  
Nucleus Accumbens Core ◽  
Accumbens Core

scholarly journals Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain

2019 ◽  
Vol 20 (4) ◽  
pp. 811 ◽  
Author(s):  
Mei Kwan ◽  
Anthony Choo ◽  
Taleen Hanania ◽  
Afshin Ghavami ◽  
Jose Beltran ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Rat Model ◽  
Dorsal Root ◽  
Mechanical Allodynia ◽  
Caspase 3 ◽  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Oral Dosing ◽  
Protein Levels

There is an unmet medical need for the development of non-addicting pain therapeutics with enhanced efficacy and tolerability. The current study examined the effects of AQU-118, an orally active inhibitor of metalloproteinase-2 (MMP-2) and MMP-9, in the spinal nerve ligation (SNL) rat model of neuropathic pain. Mechanical allodynia and the levels of various biomarkers were examined within the dorsal root ganglion (DRG) before and after oral dosing with AQU-118. The rats that received the SNL surgery exhibited significant mechanical allodynia as compared to sham controls. Animals received either vehicle, positive control (gabapentin), or AQU-118. After SNL surgery, the dorsal root ganglion (DRG) of those rats dosed with vehicle had elevated messenger RNA (mRNA) expression levels for MMP-2, IL1-β & IL-6 and elevated protein levels for caspase-3 while exhibiting decreased protein levels for myelin basic protein (MBP) & active IL-β as compared to sham controls. Rats orally dosed with AQU-118 exhibited significantly reduced mechanical allodynia and decreased levels of caspase-3 in the DRG as compared to vehicle controls. Results demonstrate that oral dosing with the dual active, MMP-2/-9 inhibitor, AQU-118, attenuated mechanical allodynia while at the same time significantly reduced the levels of caspase-3 in the DRG.

Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain

2005 ◽  
Vol 376 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Gilles R. Dubé ◽  
Kathy L. Kohlhaas ◽  
Lynne E. Rueter ◽  
Carol S. Surowy ◽  
Michael D. Meyer ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Rat Model ◽  
Dorsal Root ◽  
Nicotinic Receptors ◽  
Dorsal Root Ganglion Neurons ◽  
Neuronal Nicotinic Receptors ◽  
Ganglion Neurons
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