Conversion of Intrathecal Opioids to Fentanyl in Chronic Pain Patients With Implantable Pain Pumps: A Retrospective Study

2019 ◽  
Vol 22 (7) ◽  
pp. 823-827 ◽  
Author(s):  
David Daewhan Kim ◽  
Ankit Patel ◽  
Nabil Sibai
Keyword(s):  
Chronic Pain ◽  
Retrospective Study ◽  
Chronic Pain Patients ◽  
Pain Patients

scholarly journals Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study

2020 ◽  
Vol 10 (4) ◽  
pp. 198
Author(s):  
Victoria Rollason ◽  
Célia Lloret-Linares ◽  
Kuntheavy Ing Lorenzini ◽  
Youssef Daali ◽  
Marianne Gex-Fabry ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Retrospective Study ◽  
Cytochromes P450 ◽  
Response To Treatment ◽  
Glycoprotein P ◽  
Chronic Pain Patients ◽  
Comt Activity ◽  
Pain Center ◽  
Pain Patients ◽  
Drug Metabolising Enzymes

This retrospective study evaluates the link between an adverse drug reaction (ADR) or a non-response to treatment and cytochromes P450 (CYP), P-glycoprotein (P-gp) or catechol-O-methyltransferase (COMT) activity in patients taking analgesic drugs for chronic pain. Patients referred to a pain center for an ADR or a non-response to an analgesic drug between January 2005 and November 2014 were included. The genotype and/or phenotype was obtained for assessment of the CYPs, P-gp or COMT activities. The relation between the event and the result of the genotype and/or phenotype was evaluated using a semi-quantitative scale. Our analysis included 243 individual genotypic and/or phenotypic explorations. Genotypes/phenotypes were mainly assessed because of an ADR (n = 145, 59.7%), and the majority of clinical situations were observed with prodrug opioids (n = 148, 60.9%). The probability of a link between an ADR or a non-response and the genotypic/phenotypic status of the patient was evaluated as intermediate to high in 40% and 28.2% of all cases, respectively. The drugs in which the probability of an association was the strongest were the prodrug opioids, with an intermediate to high link in 45.6% of the cases for occurrence of ADRs and 36.0% of the cases for non-response. This study shows that the genotypic and phenotypic approach is useful to understand ADRs or therapeutic resistance to a usual therapeutic dosage, and can be part of the evaluation of chronic pain patients.

scholarly journals Cognitive factors associated with locomotive syndrome in chronic pain patients: A retrospective study

2020 ◽  
Author(s):  
Hironori Tsuji ◽  
Tomoko Tetsunaga ◽  
Tomonori Tetsunaga ◽  
Haruo Misawa ◽  
Keiichiro Nishida ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Retrospective Study ◽  
Cognitive Factors ◽  
Locomotive Syndrome ◽  
Factors Associated ◽  
Chronic Pain Patients ◽  
Pain Patients

Pain Influences Several Levels of Attention

2005 ◽  
Vol 16 (4) ◽  
pp. 235-242 ◽  
Author(s):  
Astrid von Bueren Jarchow ◽  
Bogdan P. Radanov ◽  
Lutz Jäncke
Keyword(s):  
Chronic Pain ◽  
Divided Attention ◽  
Covert Attention ◽  
Attention Task ◽  
Attentional Deficits ◽  
Control Subjects ◽  
Chronic Pain Patients ◽  
Divided Attention Task ◽  
Pain Stimuli ◽  
Pain Patients

Abstract: The aim of the present study was to examine to what extent chronic pain has an impact on various attentional processes. To measure these attention processes a set of experimental standard tests of the “Testbatterie zur Aufmerksamkeitsprüfung” (TAP), a neuropsychological battery testing different levels of attention, were used: alertness, divided attention, covert attention, vigilance, visual search, and Go-NoGo tasks. 24 chronic outpatients and 24 well-matched healthy control subjects were tested. The control subjects were matched for age, gender, and education. The group of chronic pain patients exhibited marked deficiencies in all attentional functions except for the divided attention task. Thus, the data supports the notion that chronic pain negatively influences attention because pain patients` attention is strongly captivated by the internal pain stimuli. Only the more demanding divided attention task has the capability to distract the focus of attention to the pain stimuli. Therefore, the pain patients are capable of performing within normal limits. Based on these findings chronic pain patients' attentional deficits should be appropriately evaluated and considered for insurance and work related matters. The effect of a successful distraction away from the pain in the divided attention task can also open new therapeutic aspects.

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