Exploration of the Impact of Brief Noninvasive Vagal Nerve Stimulation on EEG and Event‐Related Potentials

2018 ◽  
Vol 22 (5) ◽  
pp. 564-572 ◽  
Author(s):  
Jeffrey D. Lewine ◽  
Kim Paulson ◽  
Nitin Bangera ◽  
Bruce J. Simon
Keyword(s):  
Nerve Stimulation ◽  
Event Related Potentials ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Related Potentials ◽  
The Impact

scholarly journals The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task

2020 ◽  
Vol 10 (6) ◽  
pp. 404 ◽  
Author(s):  
Claire V. Warren ◽  
María J. Maraver ◽  
Alberto de Luca ◽  
Bruno Kopp
Keyword(s):  
Nerve Stimulation ◽  
Event Related Potentials ◽  
Vagal Nerve ◽  
Event Related Potential ◽  
Vagal Nerve Stimulation ◽  
Healthy Individuals ◽  
Non Invasive ◽  
Oddball Task ◽  
Related Potentials ◽  
Stimulation Technique

Transcutaneous auricular Vagal Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique associated with possible modulation of norepinephrinergic (NE) activity. NE is suspected to contribute to generation of the P3 event-related potential. Recent evidence has produced equivocal evidence whether taVNS influences the P3 in healthy individuals during oddball tasks. We examined the effect of taVNS on P3 amplitudes using a novel visual Bayesian oddball task, which presented 200 sequences of three stimuli. The three consecutive stimuli in each sequence are labelled Draw 1, Draw 2 and Draw 3. In total, 47 Subjects completed this visual Bayesian oddball task under randomised sham and active taVNS stimulation in parallel with an electroencephalographic (EEG) recording. We conducted exploratory analyses of the effect of taVNS on P3 amplitudes separately for Draws. We found typical oddball effects on P3 amplitudes at Draws 1 and 2, but not Draw 3. At Draw 2, the oddball effect was enhanced during active compared to sham taVNS stimulation. These data provide evidence that taVNS influences parietal P3 amplitudes under specific circumstances. Only P3 amplitudes at Draw 2 were affected, which may relate to closure of Bayesian inference after Draw 2. Our findings seemingly support previously reported links between taVNS and the NE system.

Effect of vagal nerve stimulation on auditory and visual event-related potentials

2001 ◽  
Vol 8 (5) ◽  
pp. 457-461 ◽  
Author(s):  
M. Brazdil ◽  
P. Chadim ◽  
P. Daniel ◽  
R. Kuba ◽  
I. Rektor ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Event Related Potentials ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Related Potentials

scholarly journals The long-term outcome of children with refractory epilepsy after a vagal nerve stimulator implantation: CHU Sainte-Justine experience

2015 ◽  
Vol 42 (S1) ◽  
pp. S7-S7
Author(s):  
ML Kaseka ◽  
LS Carmant ◽  
E Desplats ◽  
L Crevier ◽  
P Major ◽  
...  
Keyword(s):  
Seizure Frequency ◽  
Nerve Stimulation ◽  
Refractory Epilepsy ◽  
Hospitalization Rate ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Nerve Stimulator ◽  
Vagal Nerve Stimulator ◽  
The Impact

Background: Debate persists in Canada about the cost and benefit of vagal nerve stimulation in patients with refractory epilepsy. The aim of our study was to evaluate the impact of a vagal nerve stimulator on the seizure frequency and the admission rate of children with refractory epilepsies over five years of follow-up. Methods: 52 patients were implanted between 2000-2013. Of these, 37 were followed at CHU Sainte-Justine and 21 kept seizure diaries. Seizure frequency was compared to the baseline at 6 months, 12 months, 24 months and 60 months of follow up using a multivariate ANOVA analysis. The hospitalization rate was calculated as the mean difference between the number of hospitalizations prior to and after the implantation. Results: Seizure frequency decreased by 58% at 6 months, by 61% at 12 months, by 53% at 24 months and by 63% at 60 months of follow up respectively compared to the baseline (p<0.001). The hospitalization rate decreased by 50.87% after surgery (p<0.001). Conclusion: In our population, vagal nerve stimulation has a sustained impact on seizure frequency and hospitalization rates. This supports previous data from our group and others on cost-effectiveness of the technique in children with refractory epilepsy.

Abstract 17534: Afferent Vagal Nerve Stimulation Dose Dependently Inhibits Sympathetic Nerve Activity Through the Resetting of Baroreflex Central Arc

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Yasuhiro Oga ◽  
Takuya Kishi ◽  
Keita Saku ◽  
Takamori Kakino ◽  
Akiko Nishizaki ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Nerve Activity ◽  
Baroreflex Function ◽  
Bilateral Carotid ◽  
The Impact ◽  
Dynamic Gain

Background: Arterial baroreflex is a powerful regulator of the sympathetic nerve activity (SNA) and arterial pressure (AP). Although vagal nerve stimulation (VNS) has been developed as a neuro-modulatory therapy for heart failure, the impact of VNS on baroreflex and SNA remains unknown. Since the afferent fibers of vagal nerves and of baroreceptors converge in the nucleus tractus solitarii, we investigated how the selective afferent VNS (AVNS) impacts on baroreflex in regulating SNA and AP. Methods: We used 6 anesthetized Sprague-Dawley rats (530±11g). We vascularly isolated bilateral carotid sinuses and servo-controlled intra-sinus pressure (CSP). We measured AP, CSP and splanchnic SNA simultaneously. We attached an electrode to the vagal nerve. We established the baseline intensity (voltage) of VNS that reduced heart rate by 10-20%. We then sectioned the vagal nerve at the caudal side of the electrode. We conducted AVNS at 3 doses, baseline, 2xbaseline and 4xbaseline. We changed CSP stepwise from 60 to 160mmHg to analyze static baroreflex function with/without AVNS. To estimate dynamic baroreflex function, we perturbed CSP using binary random sequence (mean AP±20mmHg) and compared the transfer functions (TF) with/without AVNS. Results: AVNS dose-dependently shifted the CSP-SNA relation downward (p<0.05, Fig. 1) without changing the maximum gain, while did not affect the SNA-AP relation (Fig. 2). The TF of CSP-SNA relation approximated a high pass filter characteristics. AVNS dose-dependently decreased the dynamic gain (Control: 0.72±0.20, baseline: 0.46±0.14, 2xbaseline: 0.38±0.12, 4xbaseline: 0.20±0.08 %/mmHg, p<0.05), whereas did not affect the TF of SNA-AP relation. Conclusions: AVNS dose-dependently suppresses SNA by resetting the static CSP-SNA relation, i.e., the baroreflex central arc. However, AVNS reduces the dynamic gain of baroreflex central arc. We conclude that AVNS lowers SNA at the expense of compromising dynamic AP stabilization.

Benefit of vagal nerve stimulation in epilepsia partialis continua: a case report

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
C Bussmann ◽  
HM Meinck ◽  
HH Steiner ◽  
W Broxtermann ◽  
CG Bien ◽  
...  
Keyword(s):  
Case Report ◽  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Epilepsia Partialis Continua
Sign in / Sign up

Export Citation Format

Share Document