Retrospective Case Series on the Treatment of Painful Diabetic Peripheral Neuropathy With Dorsal Root Ganglion Stimulation

2018 ◽  
Vol 21 (8) ◽  
pp. 787-792 ◽  
Author(s):  
Sam Eldabe ◽  
Anthony Espinet ◽  
Anders Wahlstedt ◽  
Porhan Kang ◽  
Liong Liem ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Diabetic Peripheral Neuropathy ◽  
Dorsal Root ◽  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Painful Diabetic Peripheral Neuropathy

scholarly journals WenTong HuoXue Cream Can Inhibit the Reduction of the Pain-Related Molecule PLC-β3 in the Dorsal Root Ganglion of a Rat Model of Diabetic Peripheral Neuropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Chengcheng Feng ◽  
Lijuan Xu ◽  
Shiyun Guo ◽  
Qian Chen ◽  
Yuguo Shen ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Sciatic Nerve ◽  
Dorsal Root Ganglion ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Dorsal Root ◽  
Nerve Conduction Velocity ◽  
Model Group ◽  
Related Molecule ◽  
Metformin Group

WenTong HuoXue Cream (WTHX-Cream) has been shown to effectively alleviate clinical symptoms of diabetic peripheral neuropathy (DPN). This study investigated the gene and protein expression of the pain-related molecule PLC-β3 in the dorsal root ganglion (DRG) of DPN rats. 88 specific pathogen-free male Wistar rats were randomly divided into placebo (10 rats) and DPN model (78 rats) groups, and the 78 model rats were used to establish the DPN model by intraperitoneal injection of streptozotocin and were then fed a high-fat diet for 8 weeks. These rats were randomly divided into the model group, the high-, medium-, and low-dose WTHX-Cream + metformin groups, the metformin group, the capsaicin cream group, and the capsaicin cream + metformin group. After 4 weeks of continuous drug administration, the blood glucose, body weight, behavioral indexes, and sciatic nerve conduction velocity were measured. The pathological structure of the DRG and the sciatic nerve were observed. PLC-β3 mRNA and protein levels in the DRG of rats were measured. Compared with the model group, the high-dose WTHX-Cream group showed increased sciatic nerve conduction velocity, improved sciatic nerve morphological changes, and increased expression of PLC-β3 mRNA and protein in the DRG. This study showed that WTHX-Cream improves hyperalgesia symptoms of DPN by inhibiting the reduction of PLC-β3 mRNA and protein expression in the diabetic DRG of DPN rats.

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