Deep Brain Stimulation for Craniocervical Dystonia (Meige Syndrome): A Report of Four Patients and a Literature-Based Analysis of Its Treatment Effects

2015 ◽  
Vol 19 (8) ◽  
pp. 818-823 ◽  
Author(s):  
Xiu Wang ◽  
Chao Zhang ◽  
Yao Wang ◽  
Chang Liu ◽  
Baotian Zhao ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Treatment Effects ◽  
Meige Syndrome ◽  
Craniocervical Dystonia ◽  
Deep Brain

Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome)

2007 ◽  
Vol 22 (13) ◽  
pp. 1885-1891 ◽  
Author(s):  
Jill L. Ostrem ◽  
William J. Marks ◽  
Monica M. Volz ◽  
Susan L. Heath ◽  
Philip A. Starr
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Cervical Dystonia ◽  
Meige Syndrome ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Pallidal deep brain stimulation in primary Meige syndrome: clinical outcomes and psychiatric features

2020 ◽  
Vol 91 (12) ◽  
pp. 1343-1348
Author(s):  
Qingpei Hao ◽  
Dongliang Wang ◽  
Jia OuYang ◽  
Hu Ding ◽  
Gaungyong Wu ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Sleep Quality ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Short Form ◽  
Depression Scale ◽  
Motor Symptoms ◽  
Meige Syndrome ◽  
Sf 36 ◽  
Deep Brain

ObjectivesTo study the efficacy and safety of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in refractory Meige syndrome (MS) and evaluate the psychiatric disorders before and after surgery.MethodsTwenty-two patients with MS treated with bilateral GPi-DBS were retrospectively analysed before surgery and after continuous neurostimulation. Before surgery, patients were assessed by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Self-Rating Depression Scale, Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and Pittsburgh Sleep Quality Index (PQSI), which corresponded to motor symptoms, depressive state, quality of life and sleep quality, respectively. The implantable pulse generator of each patient was activated at 1 month after surgery. At 1 month, 3 months, 6 months and 12 months after continuous neurostimulation, all patients were evaluated by the same scales above.ResultsThe BFMDRS movement scores decreased from 15.0±5.3 before surgery to 3.5±4.5 at 12 months after neurostimulation, with a mean improvement of 78% (p<0.001). The BFMDRS disability scores improved from 7.4±4.9 before surgery to 4.0±4.6 at 12 months after neurostimulation, with a mean improvement of 56% (p<0.001). The postoperative SF-36 scores had the remarkable improvement compared with baseline scores. Impaired sleep quality was found in 82% of patients and depression in 64% before surgery, which didn’t neither obtained amelioration after continuous neurostimulation.ConclusionsBilateral pallidal neurostimulation is a beneficial therapeutic option for refractory MS, which could improve the motor symptoms except for depression and sleep quality.

Predictive factors for long-term clinical outcomes of deep brain stimulation in the treatment of primary Meige syndrome

2020 ◽  
Vol 132 (5) ◽  
pp. 1367-1375 ◽  
Author(s):  
Xin Wang ◽  
Zhiqi Mao ◽  
Zhiqiang Cui ◽  
Xin Xu ◽  
Longsheng Pan ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Deep Brain Stimulation ◽  
Clinical Outcome ◽  
Clinical Outcomes ◽  
Brain Stimulation ◽  
Meige Syndrome ◽  
Outcome Group ◽  
Deep Brain

OBJECTIVEPrimary Meige syndrome is characterized by blepharospasm and orofacial–cervical dystonia. Deep brain stimulation (DBS) is recognized as an effective therapy for patients with this condition, but previous studies have focused on clinical effects. This study explored the predictors of clinical outcome in patients with Meige syndrome who underwent DBS.METHODSTwenty patients who underwent DBS targeting the bilateral subthalamic nucleus (STN) or globus pallidus internus (GPi) at the Chinese People’s Liberation Army General Hospital from August 2013 to February 2018 were enrolled in the study. Their clinical outcomes were evaluated using the Burke–Fahn–Marsden Dystonia Rating Scale at baseline and at the follow-up visits; patients were accordingly divided into a good-outcome group and a poor-outcome group. Putative influential factors, such as age and course of disease, were examined separately, and the factors that reached statistical significance were subjected to logistic regression analysis to identify predictors of clinical outcomes.RESULTSFour factors showed significant differences between the good- and poor-outcome groups: 1) the DBS target (STN vs GPi); 2) whether symptoms first appeared at multiple sites or at a single site; 3) the sub-item scores of the mouth at baseline; and 4) the follow-up period (p < 0.05). Binary logistic regression analysis revealed that initial involvement of multiple sites and the mouth score were the only significant predictors of clinical outcome.CONCLUSIONSThe severity of the disease in the initial stage and presurgical period was the only independent predictive factor of the clinical outcomes of DBS for the treatment of patients with Meige syndrome.

Pallidal deep brain stimulation in the treatment of Meige syndrome

2014 ◽  
Vol 48 (3) ◽  
pp. 196-199 ◽  
Author(s):  
Michał Sobstyl ◽  
Mirosław Ząbek ◽  
Zbigniew Mossakowski ◽  
Artur Zaczyński
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meige Syndrome ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

scholarly journals Outcome of Pallidal Deep Brain Stimulation in Meige Syndrome

2010 ◽  
Vol 48 (2) ◽  
pp. 134 ◽  
Author(s):  
Ju-Young Ghang ◽  
Myung-Ki Lee ◽  
Sung-Man Jun ◽  
Chang-Ghu Ghang
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meige Syndrome ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Bilateral pallidal deep brain stimulation in primary Meige syndrome

2011 ◽  
Vol 17 (2) ◽  
pp. 123-125 ◽  
Author(s):  
Wataru Sako ◽  
Ryoma Morigaki ◽  
Yoshifumi Mizobuchi ◽  
Takashi Tsuzuki ◽  
Hiroyuki Ima ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meige Syndrome ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain
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