Reversible Late Thoracic Myelopathy and Neurostimulation Tolerance Caused by Fibrous Scar Tissue Formation Around the Spinal Cord Stimulation Electrode

2015 ◽  
Vol 18 (8) ◽  
pp. 759-761 ◽  
Author(s):  
Patrick Fransen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Thoracic Myelopathy ◽  
Fibrous Scar Tissue ◽  
Stimulation Electrode ◽  
Scar Tissue Formation

Cervical cord compression secondary to epidural fibrous scar tissue around the spinal cord stimulation electrode

2016 ◽  
Vol 64 (6) ◽  
pp. 1363
Author(s):  
SayoaÁ de Eulate-Beramendi ◽  
Elena Santamarta-Liébana ◽  
RamonFernandez-De Leon ◽  
Antonio Saiz-Ayala ◽  
FernandoJ Seijo-Fernandez
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Scar Tissue ◽  
Cord Compression ◽  
Cervical Cord ◽  
Cervical Cord Compression ◽  
Fibrous Scar Tissue ◽  
Stimulation Electrode

Cervical spinal cord compression from delayed epidural scar tissue formation around plate lead for SCS

2019 ◽  
Vol 63 (3) ◽  
Author(s):  
Giusy Guzzi ◽  
Giorgio Volpentesta ◽  
Domenico Chirchiglia ◽  
Attilio Della Torre ◽  
Francesco Lavano ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cervical Spinal Cord ◽  
Scar Tissue ◽  
Cord Compression ◽  
Tissue Formation ◽  
Scar Tissue Formation

Stem cell biology and its therapeutic applications in the setting of spinal cord injury

2008 ◽  
Vol 24 (3-4) ◽  
pp. E20 ◽  
Author(s):  
Nicholas C. Bambakidis ◽  
John Butler ◽  
Eric M. Horn ◽  
Xukui Wang ◽  
Mark C. Preul ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Biology ◽  
Scar Tissue ◽  
Neural Regeneration ◽  
Great Promise ◽  
Tissue Formation ◽  
Multimodal Approach ◽  
Cord Injury ◽  
Scar Tissue Formation

✓ The development of an acute traumatic spinal cord injury (SCI) inevitably leads to a complex cascade of ischemia and inflammation that results in significant scar tissue formation. The development of such scar tissue provides a severe impediment to neural regeneration and healing with restoration of function. A multimodal approach to treatment is required because SCIs occur with differing levels of severity and over different lengths of time. To achieve significant breakthroughs in outcomes, such approaches must combine both neuroprotective and neuroregenerative treatments. Novel techniques modulating endogenous stem cells demonstrate great promise in promoting neuroregeneration and restoring function.

Dorsal myelopathy secondary to epidural fibrous scar tissue around a spinal cord stimulation electrode

2012 ◽  
Vol 17 (6) ◽  
pp. 598-601 ◽  
Author(s):  
Marta Cicuendez ◽  
Pablo M. Munarriz ◽  
Ana M. Castaño-Leon ◽  
Igor Paredes
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Late Complication ◽  
Scar Tissue ◽  
Cord Compression ◽  
Thoracic Spinal Cord ◽  
Thoracic Level ◽  
Thoracic Spinal ◽  
Fibrous Scar Tissue ◽  
One Year

The authors describe a patient with delayed thoracic spinal cord compression due to fibrous scar tissue around an epidural electrode used in spinal cord stimulation (SCS). One year after implantation of the system the stimulation became ineffective, and 1 year later the patient developed progressive paraparesis. There was no evidence of device-related complications on plain radiographs and CT scans, so the system was removed to perform MRI studies. These studies showed a dorsal myelopathy secondary to scar tissue around the electrode. At surgery thick scar tissue was resected, and the patient's neurological symptoms improved. The histological examination confirmed fibrosis, and microbiological studies excluded chronic infection. As far as the authors are aware, this complication has never been reported before at the thoracic level. Scarring around SCS electrodes should be considered as a late complication and as a possible cause of the tolerance phenomenon.

scholarly journals Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring

2021 ◽  
Vol 10 (8) ◽  
pp. 1613
Author(s):  
Alessandro Crosio ◽  
Giulia Ronchi ◽  
Benedetta Elena Fornasari ◽  
Simonetta Odella ◽  
Stefania Raimondo ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Experimental Methods ◽  
Scar Tissue ◽  
Experimental Models ◽  
Tissue Formation ◽  
Surgical Interventions ◽  
Pubmed Database ◽  
Different Types ◽  
Scar Tissue Formation

As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complications of peripheral nerve scarring and also standard and quantitative parameters to evaluate perineural scars. So far, there are no standardized methods used in experimental research, and it is, therefore, difficult to compare the results of the different antiadhesion devices.

scholarly journals VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury

2018 ◽  
Vol 7 (8) ◽  
pp. 283-297 ◽  
Author(s):  
Lyn M. Wise ◽  
Gabriella S. Stuart ◽  
Nicola C. Real ◽  
Stephen B. Fleming ◽  
Andrew A. Mercer
Keyword(s):  
Scar Tissue ◽  
Vegf Receptor ◽  
Tissue Formation ◽  
Cutaneous Injury ◽  
Scar Tissue Formation
Sign in / Sign up

Export Citation Format

Share Document