scholarly journals Diffused and Sustained Inhibitory Effects of Intestinal Electrical Stimulation on Intestinal Motility Mediated via Sympathetic Pathway

2013 ◽  
Vol 17 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Xiaotuan Zhao ◽  
Jieyun Yin ◽  
Lijie Wang ◽  
Jiande D. Z. Chen
Keyword(s):  
Electrical Stimulation ◽  
Intestinal Motility ◽  
Inhibitory Effects ◽  
Intestinal Electrical Stimulation ◽  
Sympathetic Pathway

Inhibitory effects of intestinal electrical stimulation on food intake, weight loss and gastric emptying in rats

2007 ◽  
Vol 293 (1) ◽  
pp. R78-R82 ◽  
Author(s):  
Jieyun Yin ◽  
Jing Zhang ◽  
Jiande DZ Chen
Keyword(s):  
Weight Loss ◽  
Electrical Stimulation ◽  
Gastric Emptying ◽  
Food Intake ◽  
Weight Change ◽  
Delayed Gastric Emptying ◽  
Control Diet ◽  
Control Group ◽  
Inhibitory Effects ◽  
Intestinal Electrical Stimulation

The aim was to investigate the effects of intestinal electrical stimulation (IES) on food intake, body weight, and gastric emptying in rats. An experiment on food intake and weight change was performed in 22 rats on a control diet and 10 diet-induced obese (DIO) rats for 4 wk with IES or sham IES. The effect of IES on gastric emptying was performed in another 20 rats in the control group. We found that 1) in control rats, 4-wk IES resulted in a reduction of 18.2% in the total amount of food intake compared with sham-IES ( P = 0.02); the rats treated with IES had a weight change of −1 ± 7.8g ( P = 0.03), which was equivalent to a weight loss of 6.2% due to IES when adjusted for normal growing. 2) Acute IES delayed gastric emptying by 20% in the control rats ( P < 0.01). 3) In the DIO rats, 1-wk IES with the same parameters as those used in the control rats resulted in a significant reduction in the total amount of food intake (126.6 ± 6.3 g vs. 116.9 ± 3.2 g, P < 0.01). More reduction in food intake was noted, and a significant weight change was also observed when stimulation energy was increased. 4) No adverse events were observed in any of the experiments. In conclusion, IES delays gastric emptying, reduces food intake, and decreases weight gain in control growing rats. These data suggest that it is worthy to explore therapeutic potentials of IES for obesity.

Excitatory effects of synchronized intestinal electrical stimulation on small intestinal motility in dogs

2007 ◽  
Vol 293 (6) ◽  
pp. G1190-G1195 ◽  
Author(s):  
Jieyun Yin ◽  
Jiande DZ Chen
Keyword(s):  
Electrical Stimulation ◽  
Intestinal Motility ◽  
Therapeutic Potential ◽  
Intestinal Transit ◽  
Excitatory Effect ◽  
Small Intestinal Transit ◽  
Small Bowel Motility ◽  
Small Intestinal Motility ◽  
Intestinal Electrical Stimulation ◽  
Small Intestinal

The aim of this study was to investigate effects of synchronized intestinal electrical stimulation (SIES) on small intestinal motility in dogs. Seventeen dogs were equipped with a duodenal cannula for the measurement of small bowel motility using manometry; an additional cannula was equipped in six of the dogs with 1.5 m distal to the first one for the measurement of small intestinal transit. Two pairs of bipolar electrodes were implanted on the small intestinal serosa with an interval of 5 cm; glucagon was used to induce postprandial intestinal hypomotility. Eleven dogs were used for the assessment of the small intestinal contractions in both fasting and fed states. The other six dogs were used for the measurement of small intestinal transit. We found that 1) SIES induced small intestinal contractions during phase I of the migrating motor complex (MMC) (contractile index or CI: 5.2 ± 0.6 vs. 10.3 ± 0.7, P = 0.003); 2) in the fed state, SIES significantly improved glucagon-induced small intestinal postprandial hypomotility (CI: 3.4 ± 0.5 vs. 6.0 ± 0.3, P = 0.03); 3) SIES significantly accelerated small intestinal transit delayed by glucagon (70.4 ± 3.1 vs. 44.5 ± 3.1 min, P < 0.01); 4) there was a negative correlation between the CI and transit time ( r = −0.427, P = 0.048); and 5) the excitatory effect of SIES was blocked by atropine. SIES may have a therapeutic potential for treating patients with small intestinal disorders.

scholarly journals Inhibitory effects and mechanisms of intestinal electrical stimulation on gastric tone, antral contractions, pyloric tone, and gastric emptying in dogs

2009 ◽  
Vol 296 (1) ◽  
pp. R36-R42 ◽  
Author(s):  
Xiaotuan Zhao ◽  
Jieyun Yin ◽  
Jihong Chen ◽  
Gengqing Song ◽  
Lijie Wang ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Gastric Emptying ◽  
Constant Pressure ◽  
Inhibitory Effect ◽  
Gastric Volume ◽  
Control Session ◽  
Inhibitory Effects ◽  
Gastric Tone ◽  
Intestinal Electrical Stimulation ◽  
Pyloric Tone

The aim of this study was to investigate the effects and mechanisms of intestinal electrical stimulation (IES) on gastric tone, antral and pyloric contractions, and gastric emptying in dogs. Female hound dogs were equipped with a duodenal or gastric cannula, and one pair of serosal electrodes was implanted in the small intestine. The study consisted of five different experiments. Liquid gastric emptying was assessed by collection of chyme from the duodenal cannula in a number of sessions with and without IES and with and without N-nitro-l-arginine (l-NNA). Postprandial antral and pyloric contractions were measured with and without IES and in the absence and presence of l-NNA or phentolamine by placement of a manometric catheter into the antrum and pylorus via the duodenal cannula. Gastric tone was assessed by measurement of gastric volume at a constant pressure. Gastric emptying was substantially and significantly delayed by IES or l-NNA compared with the control session. IES-induced delay of gastric emptying became normal with addition of l-NNA. IES reduced gastric tone, which was blocked by l-NNA. IES also inhibited antral contractions (frequency and amplitude), and this inhibitory effect was not blocked by l-NNA but was blocked by phentolamine. IES alone did not affect pyloric tone or resistance, but IES + l-NNA decreased pyloric tone. In conclusion, IES reduces gastric tone via the nitrergic pathway, inhibits antral contractions via the adrenergic pathway, does not affect pyloric tone, and delays liquid gastric emptying. IES-induced delay of gastric emptying is attributed to its inhibitory effects on gastric motility.

The characteristics of genistin-induced inhibitory effects on intestinal motility

2013 ◽  
Vol 36 (3) ◽  
pp. 345-352 ◽  
Author(s):  
Yong-jian Xiong ◽  
Da-peng Chen ◽  
Bo-chao Lv ◽  
Fang-fei Liu ◽  
Li Wang ◽  
...  
Keyword(s):  
Intestinal Motility ◽  
Inhibitory Effects

Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric/colonic stimulation on rectal tone in dogs

2005 ◽  
Vol 288 (6) ◽  
pp. G1195-G1198 ◽  
Author(s):  
Shi Liu ◽  
Lijie Wang ◽  
J. D. Z. Chen
Keyword(s):  
Electrical Stimulation ◽  
Inhibitory Effect ◽  
Adrenergic Blockade ◽  
Rectal Compliance ◽  
Rectal Tone ◽  
Before And After ◽  
Sensory Functions ◽  
Sympathetic Pathway ◽  
Colonic Electrical Stimulation ◽  
Stimulation Of

Gastric electrical stimulation (GES) has been shown to alter motor and sensory functions of the stomach. However, its effects on other organs of the gut have rarely been investigated. The study was performed in 12 dogs implanted with two pairs of electrodes, one on the serosa of the stomach and the other on the colon. The study was composed of two experiments. Experiment 1 was designed to study the effects of GES on rectal tone and compliance in nine dogs compared with colonic electrical stimulation (CES). Rectal tone and compliance were assessed before and after GES or CES. Experiment 2 was performed to study the involvement of sympathetic pathway in 8 of the 12 dogs. The rectal tone was recorded for 30–40 min at baseline and 20 min after intravenous guanethidine. GES or CES was given for 20 min 20 min after the initiation of the infusion. It was found that both GES and CES reduced rectal tone with comparable potency. Rectal compliance was altered neither with GES, nor with CES. The inhibitory effect of GES but not CES on rectal tone was abolished by an adrenergic blockade, guanethidine. GES inhibited rectal tone with a comparable potency with CES but did not alter rectal compliance. The inhibitory effect of GES on rectal tone is mediated by the sympathetic pathway. It should be noted that electrical stimulation of one organ of the gut may have a beneficial or adverse effect on another organ of the gut.

Putative mechanisms involved in excitatory and inhibitory effects of somatostatin on intestinal motility

1989 ◽  
Vol 257 (4) ◽  
pp. G532-G538 ◽  
Author(s):  
T. Takeda ◽  
K. Taniyama ◽  
S. Baba ◽  
C. Tanaka
Keyword(s):  
Electrical Stimulation ◽  
Longitudinal Muscle ◽  
Cholinergic Neuron ◽  
Gamma Aminobutyric Acid ◽  
Inhibitory Effects ◽  
Guinea Pig Ileum ◽  
Excitatory Effect ◽  
Ergic Neuron ◽  
Gabaa Antagonist ◽  
Stimulation Of

The mechanism of action of somatostatin on the motility of intestine was examined in the entire preparation and the longitudinal muscle attached with Auerbach's plexus (LA) preparation of guinea pig ileum, in relation to the cholinergic neuron and gamma-aminobutyric acid (GABA)ergic neuron. Somatostatin produced a transient potentiation of electrical stimulation-induced twitch contractions followed by an inhibition. The excitatory effect of somatostatin was associated with an increase in the release of [3H]acetylcholine (ACh) from the preparations preloaded with [3H]choline. Bicuculline, a GABAA antagonist, inhibited the somatostatin-induced excitatory effect. Somatostatin inhibited the electrical stimulation-induced twitch contraction and release of [3H]ACh, and the inhibition was greater in the entire preparation than in the LA. Phaclofen, a GABAB antagonist, prevented the inhibitory effects of somatostatin. Somatostatin induced a Ca2+ -dependent, tetrodotoxin-sensitive release of [3H]GABA from the preparations preloaded with [3H]GABA. Therefore somatostatin exerts excitatory and inhibitory effects on the cholinergic neuron due to the stimulation of the GABAergic neuron, and the motility of the intestine is regulated.

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