Subthalamic Deep Brain Stimulation With a New Device in Parkinson's Disease: An Open-Label Trial

2013 ◽  
Vol 16 (3) ◽  
pp. 212-218 ◽  
Author(s):  
Huan-guang Liu ◽  
Yu Ma ◽  
Kai Zhang ◽  
Ming Ge ◽  
Fan-gang Meng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Open Label ◽  
New Device ◽  
Open Label Trial ◽  
Deep Brain

scholarly journals Programming Directional Deep Brain Stimulation in Parkinson’s Disease: A Randomized Prospective Trial Comparing Early versus Delayed Stimulation Steering

2021 ◽  
pp. 1-7
Author(s):  
Ricardo Maciel ◽  
Derrick Soh ◽  
Renato P. Munhoz ◽  
Yu-Yan Poon ◽  
Suneil K. Kalia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Prospective Trial ◽  
Programming Algorithm ◽  
Open Label ◽  
Ring Mode ◽  
Randomized Prospective Trial ◽  
Deep Brain

<b><i>Introduction:</i></b> Programming directional leads poses new challenges as the optimal strategy is yet to be established. We designed a randomized control study to establish an evidence-based programming algorithm for patients with Parkinson’s disease undergoing subthalamic nucleus deep brain stimulation with directional leads. <b><i>Methods:</i></b> Fourteen consecutive patients were randomized to programming with either early or delayed (i.e., starting with a “ring mode”) steered stimulation. Motor scores, number of programming visits, calls to the clinic, battery consumption, and stimulation adjustments required were recorded and compared between groups, using the Wilcoxon signed-ranks test, after 3 months of open-label programming. <b><i>Results:</i></b> Thirteen patients (25 electrodes) were included, of which 23 were steerable. Nine out of 14 electrodes allocated to delayed steered stimulation were changed to steered mode due to side effects during the course of the study. No patients (11 electrodes) initially allocated to early steered stimulation were converted to ring mode. The 2 study arms did not differ in any of the considered measures at 3 months. <b><i>Conclusion:</i></b> Programming with early or delayed steered stimulation is equally effective in the short term. However, delayed steering is less time consuming and is not always needed.

Influence of deep brain stimulation and levodopa on signs and symptoms in Parkinson's disease

2009 ◽  
Vol 36 (S 02) ◽  
Author(s):  
J Gierthmühlen ◽  
P Arning ◽  
G Wasner ◽  
A Binder ◽  
J Herzog ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Signs And Symptoms ◽  
Deep Brain
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