Increased clearance of indoxyl sulfate in renal failure rats with the addition of watersoluble poly‐β‐cyclodextrin to the dialysate

Nephrology ◽  
2021 ◽  
Author(s):  
Shuxin Liu ◽  
Lingyun Jia ◽  
Jia Xiao ◽  
Jingyu Li ◽  
Fangfang Mei ◽  
...  
Keyword(s):  
Renal Failure ◽  
Indoxyl Sulfate

Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-induced Acute Renal Failure

2007 ◽  
Vol 24 (4) ◽  
pp. 662-671 ◽  
Author(s):  
Kazufumi Iwata ◽  
Hiroshi Watanabe ◽  
Takafumi Morisaki ◽  
Takanobu Matsuzaki ◽  
Takafumi Ohmura ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Renal Failure ◽  
Nervous System ◽  
Acute Renal Failure ◽  
Indoxyl Sulfate

The uremic toxin indoxyl sulfate reflects cardio-renal risk and intestinal-renal relationship

2011 ◽  
Vol 152 (43) ◽  
pp. 1724-1730 ◽  
Author(s):  
István Kiss
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Morbidity And Mortality ◽  
Renal Diseases ◽  
Uremic Toxin ◽  
Cardiovascular Risks ◽  
Endogenous Protein ◽  
Uremic Syndrome

Uremic syndrome and condition is primarily a result of kidney failure in which uremic toxins are accumulated. More and more attention is paid to possibilities for removal of uremic toxins, which not only means dialysis, but also takes into account special dietary considerations and treatments, which aim to absorb the toxins or reduce their production. These uremic toxins, which also increase the cardiovascular risks, play a major part in morbidity and mortality of patients suffering from chronic renal failure and those receiving renal replacement therapy. One of them is a member of the indol group, the indoxyl sulfate. This toxin is difficult to remove with dialysis and is an endogenous protein-bound uremic toxin. Today we know that indoxyl sulfate is a vascular-nephrotoxic agent, which is able to enhance progression of cardiovascular and renal diseases. It is of particular importance that because of its redox potency, this toxin causes oxidative stress and antioxidant effects at the same time and, on top of that, it is formed in the intestinal system. Its serum concentration depends on the nutrition and the tubular function and, therefore, it can also signal the progression of chronic renal failure independently of glomerular filtration rate. Successful removal of indoxyl sulfate reduces the morbidity and mortality and improves survival. Therefore, it could be a possible target or area to facilitate the reduction of uremia in chronic renal failure. The use of probiotics and prebiotics with oral adsorbents may prove to be a promising opportunity to reduce indoxyl sulfate accumulation. Orv. Hetil., 2011, 152, 1724–1730.

scholarly journals Indoxyl Sulfate Serum Level in Chronic Renal Failure Patients detected using Fluorescence-HPLC

2012 ◽  
Vol 31 (2) ◽  
pp. A26
Author(s):  
Chuan Zou ◽  
Fuhua Lu ◽  
Yuchi Wu ◽  
Qizhan Lin ◽  
Xusheng Liu
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Serum Level ◽  
Indoxyl Sulfate

scholarly journals Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model

2018 ◽  
Vol 315 (4) ◽  
pp. F824-F833 ◽  
Author(s):  
Eikan Mishima ◽  
Shinji Fukuda ◽  
Yoshitomi Kanemitsu ◽  
Daisuke Saigusa ◽  
Chikahisa Mukawa ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Kidney Disease ◽  
Therapeutic Option ◽  
Short Chain Fatty Acids ◽  
Inhibitory Effect ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Vehicle Group ◽  
Microbiota Composition

Accumulation of uremic toxins, which exert deleterious effects in chronic kidney disease, is influenced by the intestinal environment; the microbiota contributes to the production of representative uremic toxins, including p-cresyl sulfate and indoxyl sulfate. Canagliflozin is a sodium-glucose cotransporter (SGLT) 2 inhibitor, and it also exerts a modest inhibitory effect on SGLT1. The inhibition of intestinal SGLT1 can influence the gastrointestinal environment. We examined the effect of canagliflozin on the accumulation of uremic toxins in chronic kidney disease using adenine-induced renal failure mice. Two-week canagliflozin (10 mg/kg po) treatment did not influence the impaired renal function; however, it significantly reduced the plasma levels of p-cresyl sulfate and indoxyl sulfate in renal failure mice (a 75% and 26% reduction, respectively, compared with the vehicle group). Additionally, canagliflozin significantly increased cecal short-chain fatty acids in the mice, suggesting the promotion of bacterial carbohydrate fermentation in the intestine. Analysis of the cecal microbiota showed that canagliflozin significantly altered microbiota composition in the renal failure mice. These results indicate that canagliflozin exerts intestinal effects that reduce the accumulation of uremic toxins including p-cresyl sulfate. Reduction of accumulated uremic toxins by canagliflozin could provide a potential therapeutic option in chronic kidney disease.

Accumulation of Indoxyl Sulfate in OAT1/3-Positive Tubular Cells in Kidneys of Patients With Chronic Renal Failure

2006 ◽  
Vol 16 (3) ◽  
pp. 199-203 ◽  
Author(s):  
Kentaro Taki ◽  
Sakurako Nakamura ◽  
Marius Miglinas ◽  
Atsushi Enomoto ◽  
Toshimitsu Niwa
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Indoxyl Sulfate ◽  
Tubular Cells

Carbonic-adsorbent AST-120 reduces overload of indoxyl sulfate and the plasma level of TGF-β1 in patients with chronic renal failure

2006 ◽  
Vol 10 (4) ◽  
pp. 262-267 ◽  
Author(s):  
Shuji Iida ◽  
Keisuke Kohno ◽  
Junko Yoshimura ◽  
Seiji Ueda ◽  
Michiaki Usui ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Plasma Level ◽  
Indoxyl Sulfate ◽  
Tgf Β1

Uremic Toxicity: Urinary Indoxyl Sulfate is a Clinical Factor that Affects the Progression of Renal Failure

1999 ◽  
Vol 25 (1-2) ◽  
pp. 118-122 ◽  
Author(s):  
Toshimitsu Niwa ◽  
Isao Aoyama ◽  
Fumio Takayama ◽  
Saori Tsukushi ◽  
Takashi Miyazaki ◽  
...  
Keyword(s):  
Renal Failure ◽  
Indoxyl Sulfate ◽  
Clinical Factor ◽  
Progression Of Renal Failure

scholarly journals SUN-158 EFFECT OF UREMIC TOXIN-INDOXYL SULFATE ON INTESTINAL DEFENSIN EXPRESSION IN RENAL FAILURE MICE.

2019 ◽  
Vol 4 (7) ◽  
pp. S223
Author(s):  
M. Satoh ◽  
M. Kondo ◽  
Y. Wada ◽  
S. Itano ◽  
K. Kidokoro ◽  
...  
Keyword(s):  
Renal Failure ◽  
Indoxyl Sulfate ◽  
Uremic Toxin
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