Demographics and long‐term outcomes of children with end‐stage kidney disease: a 20‐year territory‐wide study

Nephrology ◽  
2021 ◽  
Author(s):  
Eugene Yu Hin Chan ◽  
Desmond Yat Hin Yap ◽  
Wilfred Hing Sang Wong ◽  
Tsz Wai Ho ◽  
Pak Chiu Tong ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Long Term Outcomes ◽  
End Stage Kidney Disease ◽  
End Stage

scholarly journals Adolescents and Young Adults with Chronic or End-Stage Kidney Disease

2016 ◽  
Vol 41 (1-3) ◽  
pp. 205-210 ◽  
Author(s):  
Maria E. Ferris ◽  
J. Alexander Miles ◽  
Meredith L. Seamon
Keyword(s):  
Young Adults ◽  
Kidney Disease ◽  
Psychosocial Development ◽  
Critical Time ◽  
Adolescents And Young Adults ◽  
Adolescent And Young Adult ◽  
Long Term Outcomes ◽  
End Stage Kidney Disease ◽  
End Stage

Background: Adolescents and young adults face unique and complex physical, psychological, and family challenges. Despite improvements in care for chronic kidney disease (CKD) and end-stage kidney disease (ESKD), long-term mortality for children, adolescents, and young adults with CKD remains substantially higher than their healthy counterparts. Summary: In this article, we discuss the complex challenges that adolescent and young adult CKD/ESKD patients face. Adolescents have different CKD etiologies and progress along a course dissimilar to the adult population, but have similar multifarious comorbidities. In the setting of puberty and learning to become self-sufficient, adolescence is a critical time for growth and psychosocial development. Physiological complications of CKD underlie many of the long-term outcomes. CKD-mineral and bone disorder and anemia are particularly challenging given that they are exacerbated by the rapid growth of adolescents. Endocrine imbalances and malnutrition can delay and limit growth. All of these factors, together with family dynamics and socioeconomic status, contribute to the poor long-term outcomes and decreased quality of life (QoL) for these patients and their families. Key Messages: Care for the adolescent CKD/ESKD population is uniquely challenging, but research has identified ways in which we can continue to improve long-term outcomes and QoL for adolescents with CKD/ESKD.

scholarly journals Long-term outcomes of end-stage kidney disease for patients with lupus nephritis

2016 ◽  
Vol 89 (6) ◽  
pp. 1337-1345 ◽  
Author(s):  
Lei Zhang ◽  
Gavin Lee ◽  
Xusheng Liu ◽  
Elaine M. Pascoe ◽  
Sunil V. Badve ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Lupus Nephritis ◽  
Long Term Outcomes ◽  
End Stage Kidney Disease ◽  
End Stage

scholarly journals Long-term outcomes following vehicle trauma related acute kidney injury requiring renal replacement therapy: A nationwide population study

2020 ◽  
Author(s):  
Chieh-Kai Chan ◽  
John R Prowle ◽  
Vin-Cent Wu
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Kidney Disease ◽  
Replacement Therapy ◽  
Kidney Injury ◽  
Long Term Outcomes ◽  
End Stage Kidney Disease ◽  
End Stage ◽  
Long Term Mortality

Abstract Background Acute kidney injury (AKI) is a frequent complication of traumatic injury; however, long-term outcomes such as mortality and end-stage kidney disease (ESKD) have been rarely reported in this important patient population. We compared the long-term outcome of traumatic and non-traumatic AKI requiring renal replacement therapy (AKI-RRT). Methods This nationwide cohort study used data from the Taiwan National Health Insurance Research Database. Vehicle-trauma patients developing AKI-RRT during hospitalization were identified, and matching non-traumatic AKI-RRT patients were identified between 2000 and 2010. The incidences of end-stage kidney disease (ESKD), 30-day, and long-term mortality were evaluated, and clinical and demographic associations with these outcomes were identified using Cox proportional hazards regression models. Results 546 traumatic AKI-RRT patients, median age 47.6 years (interquartile range: 29.0-64.3) and 76.4% male, were identified. Compared to non-traumatic AKI-RRT, traumatic AKI-RRT patients had longer length of stay in hospital [median (IQR):15 (5-34) days vs 6 (3-11) days; p < 0.001). After propensity matching with non-traumatic AKI-RRT cases with similar demographic and clinical characteristics. Traumatic AKI-RRT patients had lower rates of long-term mortality (adjusted hazard ratio (HR), 0.488; 95% CI, 0.405-0.588; p < 0.001), but similar rates of ESKD (HR, 1.075; 95% CI, 0.767–1.509; p = 0.674) and short-term risk of death (HR, 1.165; 95% CI, 0.920-1.476; p = 0.205) as non-traumatic AKI-RRT patients. Conclusions Despite severe injuries, traumatic AKI-RRT patients had better long-term survival than non-traumatic AKI-RRT patients, but a similar risk of ESKD. Our results provide a better understanding of long-term outcomes after traumatic AKI-RRT.

Long-term outcomes of end-stage kidney disease for patients with IgA nephropathy: A multi-centre registry study

Nephrology ◽  
2016 ◽  
Vol 21 (5) ◽  
pp. 387-396 ◽  
Author(s):  
Lei Zhang ◽  
Xusheng Liu ◽  
Elaine M Pascoe ◽  
Sunil V Badve ◽  
Neil C Boudville ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Iga Nephropathy ◽  
Registry Study ◽  
Long Term Outcomes ◽  
End Stage Kidney Disease ◽  
End Stage

Age dependence of brachial cuff-based ambulatory PWV in end-stage kidney disease patients undergoing long-term peritoneal dialysis

2021 ◽  
pp. 089686082199692
Author(s):  
Vasilios Vaios ◽  
Panagiotis I Georgianos ◽  
Georgia Vareta ◽  
Dimitrios Divanis ◽  
Evangelia Dounousi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Heart Rate ◽  
Peritoneal Dialysis ◽  
Kidney Disease ◽  
Pulse Wave ◽  
Age Dependence ◽  
End Stage Kidney Disease ◽  
End Stage

Background: The newly introduced device Mobil-O-Graph (IEM, Stolberg, Germany) combines brachial cuff oscillometry and pulse wave analysis, enabling the determination of pulse wave velocity (PWV) via complex mathematic algorithms during 24-h ambulatory blood pressure monitoring (ABPM). However, the determinants of oscillometric PWV in the end-stage kidney disease (ESKD) population remain poorly understood. Methods: In this study, 81 ESKD patients undergoing long-term peritoneal dialysis underwent 24-h ABPM with the Mobil-O-Graph device. The association of 24-h oscillometric PWV with several demographic, clinical and haemodynamic parameters was explored using linear regression analysis. Results: In univariate analysis, among 21 risk factors, 24-h PWV exhibited a positive relationship with age, body mass index, overhydration assessed via bioimpedance spectroscopy, diabetic status, history of dyslipidaemia and coronary heart disease, and it had a negative relationship with female sex and 24-h heart rate. In stepwise multivariate analysis, age ( β: 0.883), 24-h systolic blood pressure (BP) ( β: 0.217) and 24-h heart rate ( β: −0.083) were the only three factors that remained as independent determinants of 24-h PWV (adjusted R 2 = 0.929). These associations were not modified when all 21 risk factors were analysed conjointly or when the model included only variables shown to be significant in univariate comparisons. Conclusion: The present study shows that age together with simultaneously assessed oscillometric BP and heart rate are the major determinants of Mobil-O-Graph-derived PWV, explaining >90% of the total variation of this marker. This age dependence of oscillometric PWV limits the validity of this marker to detect the premature vascular ageing, a unique characteristic of vascular remodelling in ESKD.

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