Post‐renal transplant pulmonary haemorrhage in a patient with Goodpasture syndrome without renal involvement and anti‐ glomerular basement membrane antibody: A case report

Nephrology ◽  
2021 ◽  
Author(s):  
Hanbi Lee ◽  
Yohan Park ◽  
Donghyuk Kang ◽  
Sang Hun Eum ◽  
Yaeni Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Renal Involvement ◽  
Pulmonary Haemorrhage ◽  
Goodpasture Syndrome

scholarly journals SARS-CoV-2 infection and recurrence of anti-glomerular basement disease: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alexander Winkler ◽  
Emanuel Zitt ◽  
Hannelore Sprenger-Mähr ◽  
Afschin Soleiman ◽  
Manfred Cejna ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Plasma Cells ◽  
Rapidly Progressive Glomerulonephritis ◽  
Kidney Injury ◽  
Pulmonary Involvement ◽  
Pulmonary Haemorrhage ◽  
Basement Membranes ◽  
High Avidity ◽  
History Of

Abstract Background Anti-glomerular basement membrane disease (GBM) disease is a rare autoimmune disease causing rapidly progressive glomerulonephritis and pulmonary haemorrhage. Recently, an association between COVID-19 and anti-glomerular basement membrane (anti-GBM) disease has been proposed. We report on a patient with recurrence of anti-GBM disease after SARS-CoV-2 infection. Case presentation The 31-year-old woman had a past medical history of anti-GBM disease, first diagnosed 11 years ago, and a first relapse 5 years ago. She was admitted with severe dyspnoea, haemoptysis, pulmonary infiltrates and acute on chronic kidney injury. A SARS-CoV-2 PCR was positive with a high cycle threshold. Anti-GBM autoantibodies were undetectable. A kidney biopsy revealed necrotising crescentic glomerulonephritis with linear deposits of IgG, IgM and C3 along the glomerular basement membrane, confirming a recurrence of anti-GBM disease. She was treated with steroids, plasma exchange and two doses of rituximab. Pulmonary disease resolved, but the patient remained dialysis-dependent. We propose that pulmonary involvement of COVID-19 caused exposure of alveolar basement membranes leading to the production of high avidity autoantibodies by long-lived plasma cells, resulting in severe pulmonary renal syndrome. Conclusion Our case supports the assumption of a possible association between COVID-19 and anti-GBM disease.

scholarly journals Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report

2006 ◽  
Vol 10 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Eduardo José Bellotto Monteiro ◽  
Daiane Caron ◽  
Carlos Alberto Balda ◽  
Marcello Franco ◽  
Aparecido Bernardo Pereira ◽  
...  
Keyword(s):  
Case Report ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Positive Patient ◽  
Hiv Positive ◽  
Patient Case

A Novel LMX1B Variant Identified in a Patient Presenting with Severe Renal Involvement and Thin Glomerular Basement Membrane

Nephron ◽  
2021 ◽  
pp. 1-7
Author(s):  
Nobuhisa Morimoto ◽  
Kiyotaka Nagahama ◽  
Takayasu Mori ◽  
Takuya Fujimaru ◽  
Yukio Tsuura ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Renal Biopsy ◽  
Glomerular Basement Membrane ◽  
Kidney Diseases ◽  
Renal Involvement ◽  
Renal Tubules ◽  
Persistent Proteinuria ◽  
Previous Diagnosis ◽  
Heterozygous Variant ◽  
Nail Patella Syndrome

We report a case of nail-patella syndrome (NPS) with unusual thinning of the glomerular basement membrane (GBM) associated with a novel heterozygous variant in the <i>LMX1B</i> gene. A 43-year-old female patient with a previous diagnosis of NPS, referred to our hospital for persistent proteinuria, underwent a renal biopsy, which revealed minor glomerular abnormalities. She underwent a second renal biopsy at the age of 56 owing to the presence of persistent proteinuria and decline in serum albumin, meeting the diagnostic criteria for nephrotic syndrome. Light microscopy demonstrated glomerulosclerosis and cystic dilatation of the renal tubules. Notably, electron microscopy revealed unusual thinning of the GBM, which is quite different from typical biopsy findings observed in patients with NPS, characterized by thick GBM with fibrillary material and electron-lucent structures. Comprehensive genetic screening for 168 known genes responsible for inherited kidney diseases using a next-generation sequencing panel identified a novel heterozygous in-frame deletion-insertion (c.723_729delinsCAAC: p.[Ser242_Lys243delinsAsn]) in exon 4 of the <i>LMX1B</i> gene, which may account for the disrupted GBM structure. Further studies are warranted to elucidate the complex genotype-phenotype relationship between <i>LMX1B</i> and proper GBM morphogenesis.

scholarly journals Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Tadasu Kojima ◽  
Go Hirose ◽  
Shuuhei Komatsu ◽  
Taito Oshima ◽  
Kentaro Sugisaki ◽  
...  
Keyword(s):  
Case Report ◽  
Basement Membrane ◽  
Iga Nephropathy ◽  
Glomerular Basement Membrane
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