Very large abscesses of lower limbs by Nocardia farcinica requiring surgical management in patient with minimal change disease under chronic steroid treatment

Nephrotic syndrome presenting in pregnancy is rare and poses a diagnostic and therapeutic challenge. Timing of renal biopsy is important given the increased risk of bleeding and miscarriage, and the choice of immunosuppression is limited due to the teratogenicity profiles of standard drugs. We report and discuss a case of minimal change disease diagnosed by renal biopsy during early pregnancy and treated with corticosteroids throughout the pregnancy. Prompt diagnosis and treatment of glomerular disease in pregnancy are vital to prevent poor maternal and fetal outcomes.

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Minimal change disease and subacute interstitial nephritis in association with Edwardsiella tarda gastroenteritis following oyster consumption

IDCases ◽

10.1016/j.idcr.2021.e01236 ◽

2021 ◽

pp. e01236

Author(s):

Albert Bui ◽

Cherise Cortese ◽

Claudia R. Libertin ◽

Ivan E. Porter

Keyword(s):

Interstitial Nephritis ◽

Minimal Change Disease ◽

Minimal Change ◽

Edwardsiella Tarda

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Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease

Scientific Reports ◽

10.1038/s41598-020-80931-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Takaya Ozeki ◽

Shoichi Maruyama ◽

Toshiyuki Imasawa ◽

Takehiko Kawaguchi ◽

Hiroshi Kitamura ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Renal Biopsy ◽

Focal Segmental Glomerulosclerosis ◽

Clinical Diagnosis ◽

Clinical Characteristics ◽

Minimal Change Disease ◽

Multivariable Analysis ◽

Laboratory Data ◽

Minimal Change ◽

Segmental Glomerulosclerosis

AbstractFocal segmental glomerulosclerosis (FSGS) is a serious condition leading to kidney failure. We aimed to investigate the clinical characteristics of FSGS and its differences compared with minimal change disease (MCD) using cross-sectional data from the Japan Renal Biopsy Registry. In Analysis 1, primary FSGS (n = 996) were stratified by age into three groups: pediatric (< 18 years), adult (18–64 years), and elderly (≥ 65 years), and clinical characteristics were compared. Clinical diagnosis of nephrotic syndrome (NS) was given to 73.5% (97/132) of the pediatric, 41.2% (256/622) of the adult, and 65.7% (159/242) of the elderly group. In Analysis 2, primary FSGS (n = 306) and MCD (n = 1303) whose clinical diagnosis was nephrotic syndrome (NS) and laboratory data were consistent with NS, were enrolled. Logistic regression analysis was conducted to elucidate the variables which can distinguish FSGS from MCD. On multivariable analysis, higher systolic blood pressure, higher serum albumin, lower eGFR, and presence of hematuria associated with FSGS. In Japanese nationwide registry, primary FSGS patients aged 18–64 years showed lower rate of NS than those in other ages. Among primary nephrotic cases, FSGS showed distinct clinical features from MCD.

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Atypical presentation of rheumatoid arthritis: a case of massive bilateral pleural effusions in a patient with Caplan syndrome

BMJ Case Reports ◽

10.1136/bcr-2019-231899 ◽

2019 ◽

Vol 12 (10) ◽

pp. e231899

Author(s):

Yinglun Wu ◽

Philip C Dittmar

Keyword(s):

Rheumatoid Arthritis ◽

Atrial Fibrillation ◽

Pleural Effusion ◽

Connective Tissue ◽

Minimal Change Disease ◽

Connective Tissue Disorder ◽

Minimal Change ◽

Atypical Presentation ◽

Pleural Effusions ◽

Recent Treatment

Rheumatoid arthritis (RA) is a common connective tissue disorder affecting the synovial joints. In patients with RA, involvement of the lungs occurs in 30%–40% of cases while pleural effusions occur in only 3%–5%. However, the majority of RA-associated pleural effusions are small, unilateral and asymptomatic. We present a case of massive bilateral pleural effusions in a patient with established rheumatoid pneumoconiosis (Caplan syndrome). Interestingly, the pleural effusion occurred following recent treatment for minimal change disease and atrial fibrillation.

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