scholarly journals Validation of an international prediction model including the Oxford classification in Korean patients with IgA nephropathy

Nephrology ◽  
2021 ◽  
Author(s):  
Dohui Hwang ◽  
Kyoungjin Choi ◽  
Nam‐Jun Cho ◽  
Samel Park ◽  
Byung Chul Yu ◽  
...  
Keyword(s):  
Prediction Model ◽  
Iga Nephropathy ◽  
Oxford Classification ◽  
Korean Patients ◽  
The Oxford Classification

The Oxford Classification of IgA Nephropathy: A Retrospective Analysis

2011 ◽  
Vol 34 (5) ◽  
pp. 435-444 ◽  
Author(s):  
Timothy Yau ◽  
Stephen M. Korbet ◽  
Melvin M. Schwartz ◽  
David J. Cimbaluk
Keyword(s):  
Retrospective Analysis ◽  
Iga Nephropathy ◽  
Oxford Classification ◽  
The Oxford Classification

scholarly journals Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoei Miyabe ◽  
Kazunori Karasawa ◽  
Kenichi Akiyama ◽  
Shota Ogura ◽  
Tomo Takabe ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Clinical Findings ◽  
Grading System ◽  
Oxford Classification ◽  
Kaplan Meier ◽  
Hazard Ratios ◽  
The Oxford Classification ◽  
Renal Prognosis ◽  
Renal Survival Rate

AbstractThe Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification system (O-grade) that utilised the total MEST-C score (O-grade I: 0–1, II: 2–4, and III: 5–7 points), and the 10-year renal prognosis was analysed. The clinical findings became significantly severer with increasing O-grades, and the renal survival rate by the Kaplan–Meier method was 94.1%, 86.9%, and 74.1% for O-grades I, II, and III, respectively. The hazard ratios (HRs) for O-grades II and III with reference to O-grade I were 2.8 (95% confidence interval [CI] 1.3–6.0) and 6.3 (95% CI 2.7–14.5), respectively. In the multivariate analysis, mean arterial pressure and eGFR, proteinuria at the time of biopsy, treatment of corticosteroids/immunosuppressors, and O-grade (HR 1.63; 95% CI 1.11–2.38) were the independent factors predicting renal prognosis. Among the nine groups classified using the O-grade and Japanese clinical-grade, the renal prognosis had an HR of 15.2 (95% CI 3.5–67) in the severest group. The O-grade classified by the total score of the Oxford classification was associated with renal prognosis.

scholarly journals Comments on the Oxford classification of IgA nephropathy

2009 ◽  
Vol 76 (11) ◽  
pp. 1207 ◽  
Author(s):  
Gary S. Hill ◽  
Dominique Nochy ◽  
Khalil El Karoui
Keyword(s):  
Iga Nephropathy ◽  
Oxford Classification ◽  
The Oxford Classification

Informatics Analysis of Health Indicators and Pathological Manifestations of Foot-Process in Patients with Primary IgA Nephropathy

2021 ◽  
Vol 11 (7) ◽  
pp. 1985-1994
Author(s):  
Shanhong Shi ◽  
Fang Xing ◽  
Weiyuan Lin
Keyword(s):  
Iga Nephropathy ◽  
Statistical Difference ◽  
Lesion Group ◽  
Oxford Classification ◽  
Clinical Indicators ◽  
Mesangial Hypercellularity ◽  
Group A ◽  
The Oxford Classification ◽  
Foot Process ◽  
Group B

Objective: This paper focuses on the foot-process in renal biopsies of patients with lgA, and examines their correlation with baseline clinical indicators and pathological manifestations in patients with lgA. Method: A retrospective data of patients who performed renal biopsy proven IgA nephropathy was selected. The patients who reached the agreed standard were grouped based on the degree of foot-process. There were three groups (ABC Groups) (Du, Y. and Huang, C, 2009. The value of proteinuria and foot process fusion in the onset of prognosis of acute kidney disease. Chinese Journal of Integrated Traditional and Western Medicine, 10(1), pp.44-45): group A for patients with no obvious foot-process lesion; group B for patients with segmental foot-process; group C for patients with massive foot-process. The three groups were reviewed in the aspects of baseline clinical indicators and Oxford classification, so as to discover foot-process’ effect on patients with IgA nephropathy. Results: A total of 129 patients with IgA nephropathy were included in the study. Concerning about the clinical baseline indicators related to the degree of foot-process, the 24-hour proteinuria level at admission was statistically significant and positively correlated (r = 0.324, P = 0.000). The comparison between groups showed there was statistically significant difference between group C and group A and group B (P = 0.001, P = 0.035). According to the Oxford Classification, only the differences of mesangial hypercellularity (M) and segmental sclerosis/adhesion (S) were statistically significant (r = 0.239, P = 0.006; r = 0.257, P = 0.003) and were positively correlated. In terms of mesangial hypercellularity (M), the differences between group A and B, group A and C were statistically significant (P = 0.01, P = 0.003). The comparison between group B and group C showed statistical difference (P = −0.031) in segmental sclerosis/adhesion (S). Among the 76 patients with S0 revealed by the Oxford classification, there were 55 patients of glomerulosclerosis, which was positively correlated with the degree of foot process (r = 0.211, P = 0.016). The comparison between group A and group C showed statistical difference (P = 0.014). Conclusion: The severity foot-process was positively correlated with the level of proteinuria. Foot-process is positively related with mesangial hypercellularity, segmental sclerosis and glomerulosclerosis. With more severe the foot-process, there will be more serious mesangial hypercellularity and irreversible glomerular injury. Foot-process is positively correlated with Lee’s Pathological Grading.

scholarly journals MP084APPLICATION OF THE OXFORD CLASSIFICATION OF IGA NEPHROPATHY IN THE REAL WORLD

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii456-iii457
Author(s):  
Alastair Rankin ◽  
Bruce Mackinnon ◽  
David Kipgen ◽  
Jonathan Fox ◽  
Colin Geddes ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Real World ◽  
Oxford Classification ◽  
The Real ◽  
The Oxford Classification

scholarly journals The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility

2009 ◽  
Vol 76 (5) ◽  
pp. 546-556 ◽  
Author(s):  
Ian S.D. Roberts ◽  
◽  
H. Terence Cook ◽  
Stéphan Troyanov ◽  
Charles E. Alpers ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Oxford Classification ◽  
The Oxford Classification

A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients

2012 ◽  
Vol 60 (5) ◽  
pp. 812-820 ◽  
Author(s):  
Cai-Hong Zeng ◽  
Weibo Le ◽  
Zhaohui Ni ◽  
Minfang Zhang ◽  
Lining Miao ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Chinese Patients ◽  
Oxford Classification ◽  
The Oxford Classification

Relationship between renal CD68+ infiltrates and the Oxford Classification of IgA nephropathy

2019 ◽  
Vol 74 (4) ◽  
pp. 629-637 ◽  
Author(s):  
Maria F Soares ◽  
Vera Genitsch ◽  
Aron Chakera ◽  
Andrew Smith ◽  
Clare MacEwen ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Oxford Classification ◽  
The Oxford Classification
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