Absent erythropoietin response to anaemia with mild to moderate chronic kidney disease in pregnancy

Nephrology ◽  
2020 ◽  
Vol 26 (2) ◽  
pp. 205-205
Author(s):  
Adam Morton
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Moderate Chronic Kidney Disease ◽  
In Pregnancy

scholarly journals The association between race and income on risk of mortality in patients with moderate chronic kidney disease

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Stacey A Fedewa ◽  
William M McClellan ◽  
Suzanne Judd ◽  
Orlando M Gutiérrez ◽  
Deidra C Crews
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Risk Of Mortality ◽  
Moderate Chronic Kidney Disease

scholarly journals Prevalence and determinants of chronic kidney disease in women with hypertensive disorders in pregnancy in Nigeria: a cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Salisu M. Ishaku ◽  
Timothy Olusegun Olanrewaju ◽  
Joyce L. Browne ◽  
Kerstin Klipstein-Grobusch ◽  
Gbenga A. Kayode ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Gestational Hypertension ◽  
Monitoring Program ◽  
Sub Saharan Africa ◽  
Future Research ◽  
Hypertensive Disorders ◽  
Hypertensive Disorders In Pregnancy ◽  
Sub Saharan ◽  
In Pregnancy

Abstract Background Worldwide, hypertensive disorders in pregnancy (HDPs) complicate between 5 and 10% of pregnancies. Sub-Saharan Africa (SSA) is disproportionately affected by a high burden of HDPs and chronic kidney disease (CKD). Despite mounting evidence associating HDPs with the development of CKD, data from SSA are scarce. Methods Women with HDPs (n = 410) and normotensive women (n = 78) were recruited at delivery and prospectively followed-up at 9 weeks, 6 months and 1 year postpartum. Serum creatinine was measured at all time points and the estimated glomerular filtration rates (eGFR) using CKD-Epidemiology equation determined. CKD was defined as decreased eGFR< 60 mL/min/1.73m2 lasting for ≥ 3 months. Prevalence of CKD at 6 months and 1 year after delivery was estimated. Logistic regression analyses were conducted to evaluate risk factors for CKD at 6 months and 1 year postpartum. Results Within 24 h of delivery, 9 weeks, and 6 months postpartum, women with HDPs were more likely to have a decreased eGFR compared to normotensive women (12, 5.7, 4.3% versus 0, 2 and 2.4%, respectively). The prevalence of CKD in HDPs at 6 months and 1 year postpartum was 6.1 and 7.6%, respectively, as opposed to zero prevalence in the normotensive women for the corresponding periods. Proportions of decreased eGFR varied with HDP sub-types and intervening postpartum time since delivery, with pre-eclampsia/eclampsia showing higher prevalence than chronic and gestational hypertension. Only maternal age was independently shown to be a risk factor for decreased eGFR at 6 months postpartum (aOR = 1.18/year; 95%CI 1.04–1.34). Conclusion Prior HDP was associated with risk of future CKD, with prior HDPs being more likely to experience evidence of CKD over periods of postpartum follow-up. Routine screening of women following HDP-complicated pregnancies should be part of a postpartum monitoring program to identify women at higher risk. Future research should report on both the eGFR and total urinary albumin excretion to enable detection of women at risk of future deterioration of renal function.

Moderate Chronic Kidney Disease in Women Is Associated with Fracture Occurrence Independently of Osteoporosis

2010 ◽  
Vol 116 (3) ◽  
pp. c256-c262 ◽  
Author(s):  
Sinead Kinsella ◽  
Shawn Chavrimootoo ◽  
Michael G. Molloy ◽  
Joseph A. Eustace
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Moderate Chronic Kidney Disease

Chronic Kidney Disease in Pregnancy

2016 ◽  
Vol 3 (2) ◽  
pp. 48
Author(s):  
Ayub Akbari ◽  
Aarti Malavade ◽  
Praveen Malavade ◽  
Mohan Biyani ◽  
Swapnil Hiremath
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
In Pregnancy

scholarly journals Elevated serum anion gap in adults with moderate chronic kidney disease increases risk for progression to end-stage renal disease

2019 ◽  
Vol 316 (6) ◽  
pp. F1244-F1253 ◽  
Author(s):  
Tanushree Banerjee ◽  
Deidra C. Crews ◽  
Donald E. Wesson ◽  
Charles E. McCulloch ◽  
Kirsten L. Johansen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Anion Gap ◽  
Multivariable Regression ◽  
Moderate Chronic Kidney Disease ◽  
Stage Renal Disease ◽  
End Stage

Acid retention associated with reduced glomerular filtration rate (GFR) exacerbates nephropathy progression in partial nephrectomy models of chronic kidney disease (CKD) and might be reflected in patients with CKD with reduced estimated GFR (eGFR) by increased anion gap (AG). We explored the presence of AG and its association with CKD in 14,924 adults aged ≥20 yr with eGFR ≥ 15 ml·min−1·1.73 m−2 enrolled in the National Health and Nutrition Examination Survey III, 1988–1994, using multivariable regression analysis. The model was adjusted for sociodemographic characteristics, diabetes, and hypertension. We further examined the association between AG and incident end-stage renal disease (ESRD) using frailty models, adjusting for demographics, clinical factors, body mass index, serum albumin, bicarbonate, eGFR, and urinary albumin-to-creatinine ratio by following 558 adults with moderate CKD for 12 yr via the United States Renal Data System. Laboratory measures determined AG using the traditional, albumin-corrected, and full AG definitions. Individuals with moderate CKD (eGFR: 30–59 ml·min−1·1.73 m−2) had a greater AG than those with eGFR ≥ 60 ml·min−1·1.73 m−2 in multivariable regression analysis with adjustment for covariates. We found a graded relationship between the adjusted mean for all three definitions of AG and eGFR categories ( P trend < 0.0001). During followup, 9.2% of adults with moderate CKD developed ESRD. Those with AG in the highest tertile had a higher risk of ESRD after adjusting for covariates in a frailty model [relative hazard (95% confidence interval) for traditional AG: 1.76 (1.16–2.32)] compared with those in the middle tertile. The data suggest that high AG, even after adjusting for serum bicarbonate, is a contributing acid-base mechanism to CKD progression in adults with moderate chronic kidney disease.

Kidney disease

2016 ◽  
Author(s):  
Kate Wiles ◽  
Kate Bramham ◽  
Catherine Nelson-Piercy
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Renal Disease ◽  
Lupus Erythematosus ◽  
Immunoglobulin A ◽  
Fetal Loss ◽  
Kidney Injury ◽  
Premature Delivery ◽  
In Pregnancy

This chapter describes the physiological adaptations to pregnancy in women with and without renal disease, reports pregnancy outcomes in women with both acute kidney injury and chronic kidney disease, and discusses a management strategy for antenatal and peripartum care. Acute kidney injury (AKI) is difficult to define in pregnancy because of the physiological increase in glomerular filtration. A normal creatinine can mask renal injury in pregnancy. This chapter considers important causes of AKI in pregnancy including pre-eclampsia, HELLP syndrome, thrombotic microangiopathy, acute fatty liver of pregnancy, systemic lupus erythematosus, urinary tract infection, and obstruction. The trend in the developed world for delaying pregnancy and the increasing prevalence of obesity mean that greater numbers of pregnancies will be complicated by chronic kidney disease. Maternal and fetal complications increase with worsening prepregnancy renal function including the development of pre-eclampsia, fetal growth restriction, premature delivery, and fetal loss. Prepregnancy counselling and the intrapartum management for women with lupus nephritis, immunoglobulin A nephropathy, polycystic kidney disease, and diabetic nephropathy are discussed. Renal replacement therapies in pregnancy including both dialysis and renal transplantation are considered, and practical guidance on renal biopsy, anaesthesia, and the pharmacology of renal disease in pregnancy is offered.

Aerobic Exercise Capacity In Mild-to-moderate Chronic Kidney Disease Is Maintained Over A 5 Year-period

2018 ◽  
Vol 50 (5S) ◽  
pp. 359
Author(s):  
Helena Wallin ◽  
Anette Rickenlund ◽  
Maria E. Eriksson ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Aerobic Exercise Capacity ◽  
Moderate Chronic Kidney Disease
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