scholarly journals Protective effects and mechanisms of omega‐3 polyunsaturated fatty acid on intestinal injury and macrophage polarization in peritoneal dialysis rats

Nephrology ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1081-1089
Author(s):  
Hanfen Tang ◽  
Xuping Zhu ◽  
Cai Gong ◽  
Haiyang Liu ◽  
Fuyou Liu
Keyword(s):  
Peritoneal Dialysis ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Macrophage Polarization ◽  
Intestinal Injury ◽  
Protective Effects ◽  
Omega 3

scholarly journals Omega-3 Polyunsaturated Fatty Acid Attenuates Uremia-Induced Brain Damage in Mice

2021 ◽  
Vol 22 (21) ◽  
pp. 11802
Author(s):  
Eun-Ji Kim ◽  
Young Rok Ham ◽  
Jin Ah Shin ◽  
Jin Young Jeong ◽  
Ki Ryang Na ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Protein Expression ◽  
Brain Damage ◽  
Polyunsaturated Fatty Acid ◽  
Uremic Toxin ◽  
Protective Effects ◽  
Omega 3 ◽  
Apoptotic Protein ◽  
Mice Brain ◽  
The Brain

Although the cause of neurological disease in patients with chronic kidney disease (CKD) has not been completely identified yet, recent papers have identified accumulated uremic toxin as its main cause. Additionally, omega-3 polyunsaturated fatty acid (ω-3 PUFA) plays an important role in maintaining normal nerve function, but its protective effects against uremic toxin is unclear. The objective of this study was to identify brain damage caused by uremic toxicity and determine the protective effects of ω-3 PUFA against uremic toxin. We divided mice into the following groups: wild-type (wt) sham (n = 8), ω-3 PUFA sham (n = 8), Fat-1 sham (n = 8), ischemia-reperfusion (IR) (n = 20), and ω-3 PUFA+IR (n = 20) Fat-1+IR (n = 20). Brain tissue, kidney tissue, and blood were collected three days after the operation of mice (sham and IR operation). This study showed that Ki67 and neuronal nuclei (NeuN) decreased in the brain of uremic mice as compared to wt mice brain, but increased in the ω-3 PUFA-treated uremic mice and the brain of uremic Fat-1 mice as compared to the brain of uremic mice. The pro-apoptotic protein expressions were increased, whereas anti-apoptotic protein expression decreased in the brain of uremic mice as compared to wt mice brain. However, apoptotic protein expression decreased in the ω-3 PUFA-treated uremic mice and the brain of uremic Fat-1 mice as compared to the brain of uremic mice. Furthermore, the brain of ω-3 PUFA-treated uremic mice and uremic Fat-1 mice showed increased expression of p-PI3K, p-PDK1, and p-Akt as compared to the brain of uremic mice. We confirm that uremic toxin damages the brain and causes cell death. In these injuries, ω-3 PUFA plays an important role in neuroprotection through PI(3)K-Akt signaling.

Effects of Omega-3 Polyunsaturated Fatty-Acid Supplementation on Redox Status in Chronic Renal Failure Patients With Dyslipidemia

2010 ◽  
Vol 20 (5) ◽  
pp. 321-328 ◽  
Author(s):  
Nassima Bouzidi ◽  
Khedidja Mekki ◽  
Ali Boukaddoum ◽  
Nawel Dida ◽  
Abbou Kaddous ◽  
...  
Keyword(s):  
Renal Failure ◽  
Fatty Acid ◽  
Chronic Renal Failure ◽  
Polyunsaturated Fatty Acid ◽  
Redox Status ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation

Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis

2018 ◽  
Vol 139 ◽  
pp. 20-24 ◽  
Author(s):  
Jesús Castro-Marrero ◽  
Maria Cleofé Zaragozá ◽  
Joan Carles Domingo ◽  
Alba Martinez-Martinez ◽  
José Alegre ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Chronic Fatigue Syndrome ◽  
Polyunsaturated Fatty Acid ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Omega 3 ◽  
Fatty Acid Status ◽  
Fatigue Syndrome ◽  
Acid Status
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