Compensatory renal hypertrophy following nephrectomy: When and how?

Nephrology ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 1225-1232 ◽  
Author(s):  
Darling M Rojas‐Canales ◽  
Jordan Y Li ◽  
Leek Makuei ◽  
Jonathan M Gleadle
Keyword(s):  
Renal Hypertrophy ◽  
Compensatory Renal Hypertrophy

scholarly journals BIOCHEMICAL EVALUATION OF COMPENSATORY RENAL HYPERTROPHY

1977 ◽  
Vol 68 (7) ◽  
pp. 644-651 ◽  
Author(s):  
Takashi Umeda ◽  
Kenkichi Koiso ◽  
Hisao Takayasu
Keyword(s):  
Renal Hypertrophy ◽  
Compensatory Renal Hypertrophy ◽  
Biochemical Evaluation

Compensatory Renal Hypertrophy in Parabiotic Rats

1967 ◽  
Vol 98 (5) ◽  
pp. 548-551 ◽  
Author(s):  
James W. Thompson ◽  
Bernard Lytton
Keyword(s):  
Renal Hypertrophy ◽  
Compensatory Renal Hypertrophy

Cellular hypertrophy and renal function during compensatory renal growth

1976 ◽  
Vol 231 (4) ◽  
pp. 1191-1195 ◽  
Author(s):  
TE Northrup ◽  
RL Malvin
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Deoxyribonucleic Acid ◽  
Renal Plasma Flow ◽  
Left Kidney ◽  
Renal Hypertrophy ◽  
Compensatory Renal Growth ◽  
Compensatory Renal Hypertrophy

Simultaneous measurements of biochemical and physiological events of compensatory renal hypertrophy were made in groups of white Spartan rats. Thirty hours following right unilateral nephrectomy, the left kidney had an increased rate of renal plasma flow, glomerular filtration rate, and potassium excretion when compared to sham-nephrectomized rats. Kidney cells were also hypertrophied as evidenced by an increase in the ratio of ribonucleic to deoxyribonucleic acid. The effects of a single injection of cycloheximide and actinomycin D on compensatory growth were studied. Both drugs prevented the rise in glomerular filtration rate and renal plasma flow 30 h postnephrectomy while having no inhibitory effect on cell hypertrophy. The maintenance of nephrectomized rats on a low-sodium diet also interfered with the physiological components of the response while having no effect on ribonucleic or deoxyribonucleic acid. These suggest that the physiological and biochemical aspects of compensatory renal hypertrophy may be under separate control systems.

scholarly journals Conservation of ribosomal RNA during compensatory renal hypertrophy. A major mechanism in RNA accretion.

1976 ◽  
Vol 69 (3) ◽  
pp. 548-556 ◽  
Author(s):  
W T Melvin ◽  
A Kumar ◽  
R A Malt
Keyword(s):  
Ribosomal Rna ◽  
Cultured Cells ◽  
Compensatory Hypertrophy ◽  
Mouse Kidney ◽  
Average Increase ◽  
Renal Hypertrophy ◽  
Major Mechanism ◽  
Compensatory Renal Hypertrophy

After removal of one mouse kidney, compensatory hypertrophy in the remaining kidney is marked in 2 days by a 20% average increase in ribosomal RNA (rRNA) per cell. Both 28S and 18S RNA are conserved during the initial stages of compensatory renal hypertrophy to an extent sufficient to account for the rest of the observed accumulation of rRNA. Like some cultured cells, the kidney conserves rRNA during physiological growth.

Sign in / Sign up

Export Citation Format

Share Document